Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis

Luo, Yingchun; Zhang, Yun; Han, Xuejie; Yuan, Yue; Zhou, Yun; Gao, Yunzhen; Yu, Hui; Zhang, Jiawei; Shi, Yiya; Duan, Yu; Zhao, Xinghui; Yan, Sen; Hao, Hongting; Dai, Chenguang; Zhao, Shuai; Shi, Jing; Li, Wenpeng; Zhang, Song; Xu, Wei; Fang, Ning; Gong, Yongtai; Li, Yue

doi:10.1016/j.ebiom.2022.104087

Cited by 50 publications

(25 citation statements)

References 60 publications

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“…Luo et al demonstrated that cold exposure modulated the A. muciniphila abundance level in rats, thereby causing excessive secretion of TMAO which elevated the susceptibility to atrial fibrillation (AF) condition mainly through the enhanced infiltration of M1 macrophages in atria and increased protein expression of Casp1-p20 and cleaved GSDMD. The oral supplementation of A. muciniphila in rats significantly ameliorated the pro-AF property induced by cold exposure [ 98 ]. These results indicate a positive correlation between a higher level of TMAO or TMA with the HTN and a negative association with the abundance of the genus Akkermansia .…”

Section: Mechanisms Of Gut Microbiota-mediated Htnmentioning

confidence: 99%

The potential impact of a probiotic: Akkermansia muciniphila in the regulation of blood pressure—the current facts and evidence

et al. 2022

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Akkermansia muciniphila (A. muciniphila) is present in the human gut microbiota from infancy and gradually increases in adulthood. The potential impact of the abundance of A. muciniphila has been studied in major cardiovascular diseases including elevated blood pressure or hypertension (HTN). HTN is a major factor in premature death worldwide, and approximately 1.28 billion adults aged 30–79 years have hypertension. A. muciniphila is being considered a next-generation probiotic and though numerous studies had highlighted the positive role of A. muciniphila in lowering/controlling the HTN, however, few studies had highlighted the negative impact of increased abundance of A. muciniphila in the management of HTN. Thus, in the review, we aimed to discuss the current facts, evidence, and controversy about the role of A. muciniphila in the pathophysiology of HTN and its potential effect on HTN management/regulation, which could be beneficial in identifying the drug target for the management of HTN.

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Section: Mechanisms Of Gut Microbiota-mediated Htnmentioning

confidence: 99%

The potential impact of a probiotic: Akkermansia muciniphila in the regulation of blood pressure—the current facts and evidence

et al. 2022

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“…Although the pathogenesis of myocardial infarction is complex, oxidative stress has been proven to be crucial in the occurrence and development of myocardial infarction ( Hori and Nishida, 2009 ; Xiang et al, 2021 ; Luo et al, 2022 ). Oxidative stress reflects an imbalance between reactive oxygen species (ROS) and the anti-oxidant system, and cardiomyocytes can produce a large amount of ROS under ischemia and hypoxia ( Hou et al, 2021 ; Rasool et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Ciprofol attenuates the isoproterenol-induced oxidative damage, inflammatory response and cardiomyocyte apoptosis

Yang

Zhai

et al. 2022

Front. Pharmacol.

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Background and Purpose: Ciprofol (HSK3486), a novel 2,6-disubstituted phenol derivative, is a new intravenous anesthetic compound with a similar chemical structure to propofol. Animal studies have also shown that propofol plays a protective role in a variety of cardiovascular diseases, including myocardial infarction, myocardial ischemia-reperfusion injury and takotsubo syndrome. However, whether ciprofol exerts cardioprotective effects on myocardial infarction remains unclear. Thus, the aim of this work was to explore the potential cardioprotective mechanism of ciprofol on isoproterenol (ISO)-induced myocardial infarction.Experimental Approach: In the present study, male C57BL/6 mice were subjected to subcutaneous injection of ISO (100 mg/kg) for 2 consecutive days to induce experimental myocardial infarction. Herein, we found that ciprofol could inhibit the abnormal increase in myocardial injury enzymes, the area of myocardial infarction and cardiac dysfunction in ISO-treated mice. Ciprofol administration increased the activity of superoxide dismutase and reduced the levels of NADPH oxidase and malondialdehyde in ISO-treated hearts. Additionally, ciprofol administration markedly reduced the expression of pro-inflammatory cytokines and cardiomyocyte apoptosis. In an in vitro model, the results also confirmed that ciprofol could inhibit ISO-induced oxidative damage, the inflammatory response and cardiomyocyte apoptosis. Moreover, ciprofol can activate the sirtuin1 (Sirt1)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and Sirt1 and Nrf2 inhibition almost abolished ciprofol-mediated cardioprotective effects.Interpretation: Ciprofol protects the heart against ISO-induced myocardial infarction by reducing cardiac oxidative stress, the inflammatory response and cardiomyocyte apoptosis.

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“…These results demonstrate that treatment with Akk shows an outstanding anti-atherogenic potential by ameliorating lipid metabolism and activating the immune response to repress the formation of atherosclerotic lesions and inflammation deterioration. Moreover, a recent report found that Akk could prevent cold-related atrial fibrillation (AF) in rats by modulating TMAO-induced cardiac pyroptosis [ 90 ]. As one of the most important risk factors for AF, cold exposure is closely related to the poor prognosis of patients with AF, and exposure to cold led to elevated susceptibility to AF and reduction of Akk abundance in rats [ 90 ].…”

Section: Akkermansia Muciniphila : a Promising Probiotic Can...mentioning

confidence: 99%

“…Moreover, a recent report found that Akk could prevent cold-related atrial fibrillation (AF) in rats by modulating TMAO-induced cardiac pyroptosis [ 90 ]. As one of the most important risk factors for AF, cold exposure is closely related to the poor prognosis of patients with AF, and exposure to cold led to elevated susceptibility to AF and reduction of Akk abundance in rats [ 90 ]. Correspondingly, progressively increased plasma TMAO levels were observed in human subjects during cold weather, and the reduction of Akk abundance was an independent risk factor for cold-related AF in a cross-sectional clinical study of human subjects [ 90 ].…”

Section: Akkermansia Muciniphila : a Promising Probiotic Can...mentioning

confidence: 99%

“…As one of the most important risk factors for AF, cold exposure is closely related to the poor prognosis of patients with AF, and exposure to cold led to elevated susceptibility to AF and reduction of Akk abundance in rats [ 90 ]. Correspondingly, progressively increased plasma TMAO levels were observed in human subjects during cold weather, and the reduction of Akk abundance was an independent risk factor for cold-related AF in a cross-sectional clinical study of human subjects [ 90 ]. Oral administration of Akk ameliorates the proAF property induced by cold exposure and restores Akk abundance, which reduces TMAO levels through modulation of the microbial enzymes involved in trimethylamine (TMA) synthesis [ 90 ].…”

Section: Akkermansia Muciniphila : a Promising Probiotic Can...mentioning

confidence: 99%

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Akkermansia muciniphila as a Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression: A Role Mediated by Gut–Liver–Brain Axes?

Jian

Liu

Wang

et al. 2023

IJMS

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Appreciation of the importance of Akkermansia muciniphila is growing, and it is becoming increasingly relevant to identify preventive and/or therapeutic solutions targeting gut–liver–brain axes for multiple diseases via Akkermansia muciniphila. In recent years, Akkermansia muciniphila and its components such as outer membrane proteins and extracellular vesicles have been known to ameliorate host metabolic health and intestinal homeostasis. However, the impacts of Akkermansia muciniphila on host health and disease are complex, as both potentially beneficial and adverse effects are mediated by Akkermansia muciniphila and its derivatives, and in some cases, these effects are dependent upon the host physiology microenvironment and the forms, genotypes, and strain sources of Akkermansia muciniphila. Therefore, this review aims to summarize the current knowledge of how Akkermansia muciniphila interacts with the host and influences host metabolic homeostasis and disease progression. Details of Akkermansia muciniphila will be discussed including its biological and genetic characteristics; biological functions including anti-obesity, anti-diabetes, anti-metabolic-syndrome, anti-inflammation, anti-aging, anti-neurodegenerative disease, and anti-cancer therapy functions; and strategies to elevate its abundance. Key events will be referred to in some specific disease states, and this knowledge should facilitate the identification of Akkermansia muciniphila-based probiotic therapy targeting multiple diseases via gut–liver–brain axes.

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Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis

Cited by 50 publications

References 60 publications

The potential impact of a probiotic: Akkermansia muciniphila in the regulation of blood pressure—the current facts and evidence

The potential impact of a probiotic: Akkermansia muciniphila in the regulation of blood pressure—the current facts and evidence

Ciprofol attenuates the isoproterenol-induced oxidative damage, inflammatory response and cardiomyocyte apoptosis

Akkermansia muciniphila as a Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression: A Role Mediated by Gut–Liver–Brain Axes?

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