2019
DOI: 10.1016/j.semcancer.2019.06.002
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Akt in cancer: Mediator and more

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Cited by 517 publications
(345 citation statements)
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References 173 publications
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“…AKT1 is widely expressed in many tissues, AKT2 is expressed in mainly insulin-sensitive tissues and at low levels in other tissues, and AKT3 is expressed in only the brain and testis. The specific tissue expression patterns of the different AKT subtypes suggest their key roles in the maintenance of physiological functions in different tissues or organs [22,23].…”
Section: Aktmentioning
confidence: 99%
“…AKT1 is widely expressed in many tissues, AKT2 is expressed in mainly insulin-sensitive tissues and at low levels in other tissues, and AKT3 is expressed in only the brain and testis. The specific tissue expression patterns of the different AKT subtypes suggest their key roles in the maintenance of physiological functions in different tissues or organs [22,23].…”
Section: Aktmentioning
confidence: 99%
“…Structure of Akts' amino terminus pleckstrin homology (PH) domain and central kinase domain is conserved across evolution, while the carboxyl terminus hydrophobic and proline-rich domain is more variable. The kinase activity of Akt is regulated by phosphorylation of Thr 308 and Ser 473 situated in the PH domain, although phosphorylation of Ser 124 and Thr 450 sites are needed for sensitizing Akt toward regulatory stimuli [13]. In the classical activation pathway of Akt (Figure 1), the upstream element PI3K phosphorylates phosphatidylinositol-4,5-bisphosphate to phosphatidylinositol-3,4,5-trisphosphate (PIP3) that binds to PH domain of the constitutively active 3-phosphoinositide-dependent protein kinase (PDK)1.…”
Section: Cellular Role and Regulation Of Aktmentioning
confidence: 99%
“…PIK3CA encodes the p110α catalytic subunit of PI3K, and is the most frequently altered oncogene in human cancers, including endometrial, ovarian, colorectal, and breast cancers [123]. Mutations of mTOR and Akt are much less frequent, although, they were demonstrated in melanoma, renal carcinoma, bladder tumor, lung cancer, breast cancers, head and neck squamous cell carcinomas, and endometrial cancer [124]. PTEN loss represent the second most mutated tumor suppressor gene frequently occurring in various human cancers including colorectal cancer, breast cancer, glioblastoma, endometrial cancer, malignant melanoma, and prostate cancer [125].…”
Section: Parp-akt Interactions In Cancer Biologymentioning
confidence: 99%
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“…The phosphatidylinositol-3 kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling network is frequently activated in an aberrant manner in most of human cancers, where it controls many processes essential for tumor growth and survival [7][8][9]. A large array of small molecule inhibitors of the PI3K/Akt/mTOR signaling pathway have been studied in preclinical models of human cancer, where their proved their efficacy as antineoplastic agents.…”
Section: Introductionmentioning
confidence: 99%