2018
DOI: 10.1038/s41598-018-20755-w
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Akt regulates neurite growth by phosphorylation-dependent inhibition of radixin proteasomal degradation

Abstract: Neurite growth is controlled by a complex molecular signaling network that regulates filamentous actin (F-actin) dynamics at the growth cone. The evolutionarily conserved ezrin, radixin, and moesin family of proteins tether F-actin to the cell membrane when phosphorylated at a conserved threonine residue and modulate neurite outgrowth. Here we show that Akt binds to and phosphorylates a threonine 573 residue on radixin. Akt-mediated phosphorylation protects radixin from ubiquitin-dependent proteasomal degradat… Show more

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Cited by 15 publications
(12 citation statements)
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“…Surprisingly, although this pair of threonines has been conserved in the merlin family, no phosphorylation has been observed to date [115]. There is now growing evidence that alternate phosphorylation mechanisms and/or secondary phosphorylation sites enable ezrin, radixin and moesin (along with merlin) to be individually regulated and/or work in concert (see for example [130,131]).…”
Section: Post-translational Modifications (Ptm) Of Merlin-erm Protmentioning
confidence: 99%
“…Surprisingly, although this pair of threonines has been conserved in the merlin family, no phosphorylation has been observed to date [115]. There is now growing evidence that alternate phosphorylation mechanisms and/or secondary phosphorylation sites enable ezrin, radixin and moesin (along with merlin) to be individually regulated and/or work in concert (see for example [130,131]).…”
Section: Post-translational Modifications (Ptm) Of Merlin-erm Protmentioning
confidence: 99%
“…A tight control of the actin cytoskeleton is crucial for the formation and functionality of the new growth cone. Regulation of actin requires the initiation of the phosphatidylinositol-3-kinase (PI3K)/Akt signaling cascade (Henle et al, 2011;Kakumoto and Nakata, 2013;Berry et al, 2016;Curcio and Bradke, 2018;Jin et al, 2018). Akt phosphorylation induces the activation of nitric oxide synthase (NOS), whose function is associated with actin reorganization and cell survival (Michell et al, 1999;Van Wagenen and Rehder, 2001;Welshhans and Rehder, 2005;Cooke et al, 2013;Sild et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…3). Although it has been previously shown in neuronal and epidermal cell cultures, and more recently in PC12 cells, that PI3 kinase-Akt signaling pathway, which usually positioned as upstream effectors of GSK3β, regulate ERM phosphorylation levels [161725], it is first time to directly show in the NAcc that this pathway also regulates ERM signaling in this region.…”
Section: Discussionmentioning
confidence: 99%
“…It is interesting to compare our present data with a recent report by Jin et al . (2018) [25]. They found that an Akt inhibitor specifically decreased radixin protein levels, but not ezrin and moesin, in PC12 cells.…”
Section: Discussionmentioning
confidence: 99%