Aktionsstrom und optisches Verhalten des Froschmuskels in ihrer zeitlichen Beziehung zur Zuckung

Schaefer, H.; Göpfert, H.

doi:10.1007/bf01767676

Cited by 27 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The transition from stage G to D is also the basis of a very small transitory lengthening preceding the usual shortening of muscle, discovered by Rauh [ 84 ] and described as a “nose” in his myograms. It was also found by Fischer [ 85 ], reviewed by Schaefer and Göpfert [ 86 ], and named “latency-relaxation” by Sandow [ 87 ]. A. V. Hill found no such elongation in muscles under very low tension and concluded [ 67 , 88 ] that it must arise in a structure parallel to the contractile system.…”

Section: Resultsmentioning

confidence: 83%

Large-scale Models Reveal the Two-component Mechanics of Striated Muscle

Jarosch¹

2008

IJMS

View full text Add to dashboard Cite

This paper provides a comprehensive explanation of striated muscle mechanics and contraction on the basis of filament rotations. Helical proteins, particularly the coiled-coils of tropomyosin, myosin and α-actinin, shorten their H-bonds cooperatively and produce torque and filament rotations when the Coulombic net-charge repulsion of their highly charged side-chains is diminished by interaction with ions. The classical "two-component model" of active muscle differentiated a "contractile component" which stretches the "series elastic component" during force production. The contractile components are the helically shaped thin filaments of muscle that shorten the sarcomeres by clockwise drilling into the myosin cross-bridges with torque decrease (= force-deficit). Muscle stretch means drawing out the thin filament helices off the cross-bridges under passive counterclockwise rotation with torque increase (= stretch activation). Since each thin filament is anchored by four elastic α-actinin Z-filaments (provided with forceregulating sites for Ca 2+ binding), the thin filament rotations change the torsional twist of the four Z-filaments as the "series elastic components". Large scale models simulate the changes of structure and force in the Z-band by the different Z-filament twisting stages A, B, C, D, E, F and G. Stage D corresponds to the isometric state. The basic phenomena of muscle physiology, i. e. latency relaxation, Fenn-effect, the force-velocity relation, the length-tension relation, unexplained energy, shortening heat, the Huxley-Simmons phases, etc. are explained and interpreted with the help of the model experiments.

show abstract

Section: Resultsmentioning

confidence: 83%

Large-scale Models Reveal the Two-component Mechanics of Striated Muscle

Jarosch¹

2008

IJMS

View full text Add to dashboard Cite

show abstract

“…Schaefer and Gopfert (34) pointed out that in the isometric condition the tension change curve was not smoothed by the stimulation of 170 c/sec. Similar discontinuity of isometric tetanus was pointed out by Nicolai (37,38) or Gilson et al (32,39) from another point of view.…”

Section: Methodsmentioning

confidence: 99%

Studies on the Tension and Shortening as Well as the Work Done During Muscle Twitch and Tetanus

Mashima

Tanaka

1954

Jpn.J.Physiol

View full text Add to dashboard Cite

“…Further various utilizations of the piezoelectric tech nique have been made for direct recording of muscle responses (18, 27 to 30) and, by using electronic differentiation, for obtaining the first time derivative of the tension output throughout the course of the twitch (31). A special strain gauge (32) and condensor and carbon microphones (33,34) have been employed a. s pickups for either direct or differentiated registration. In general, these methods possess certain advantages over conventional myographic techAnnu.…”

Section: Mechanicsmentioning

confidence: 99%

Muscle

Sandow¹

1949

Annu. Rev. Physiol.

View full text Add to dashboard Cite

Aktionsstrom und optisches Verhalten des Froschmuskels in ihrer zeitlichen Beziehung zur Zuckung

Cited by 27 publications

References 0 publications

Large-scale Models Reveal the Two-component Mechanics of Striated Muscle

Large-scale Models Reveal the Two-component Mechanics of Striated Muscle

Studies on the Tension and Shortening as Well as the Work Done During Muscle Twitch and Tetanus

Muscle

Contact Info

Product

Resources

About