Aktive Mittelohrimplantate – mehr als „nur“ ein Hörgerät

Praetorius, Mark

doi:10.1007/s00106-007-1600-2

Cited by 4 publications

References 15 publications

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An Overview of Nanoparticle Based Delivery for Treatment of Inner Ear Disorders

Pyykkö

Zou

Schrott‐Fischer

et al. 2016

Methods in Molecular Biology

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Nanoparticles offer new possibilities for inner ear treatment as they can carry a variety of drugs, protein, and nucleic acids to inner ear. Nanoparticles are equipped with several functions such as targetability, immuno-transparency, biochemical stability, and ability to be visualized in vivo and in vitro. A group of novel peptides can be attached to the surface of nanoparticles that will enhance the cell entry, endosomal escape, and nuclear targeting. Eight different types of nanoparticles with different payload carrying strategies are available now. The transtympanic delivery of nanoparticles indicates that, depending on the type of nanoparticle, different migration pathways into the inner ear can be employed, and that optimal carriers can be designed according to the intended cargo. The use of nanoparticles as drug/gene carriers is especially attractive in conjunction with cochlear implantation or even as an inclusion in the implant as a drug/gene reservoir.

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An Overview of Nanoparticle Based Delivery for Treatment of Inner Ear Disorders

Pyykkö

Zou

Schrott‐Fischer

et al. 2016

Methods in Molecular Biology

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Elektronische Systeme zum Ersatz der defizienten Hörleistung

Plinkert

Praetorius

2010

Altern Gestalten

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Tauchtauglichkeit im HNO-Bereich

Klingmann

Praetorius

Böhm

et al. 2008

HNO

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In line with the rising number of recreational divers, the otorhinolaryngologist has to deal with growing numbers of diving-associated disorders of the ear, nose and throat (ENT). Nevertheless, the majority of divers present to their ENT doctor for assessment of their fitness to dive. On the basis of long-term follow-up examinations and increasing experience in diving medicine, even divers with a history of ENT problems can be considered fit to dive. Therefore, diving is possible after tympanoplasty, surgery to improve hearing including stapesplasty, after implantation of middle ear amplifiers or cochlear implants, after sinus or scull base surgery and even after canal wall down mastoidectomy, provided that certain requirements are fulfilled. Assessing fitness to dive after inner ear barotrauma as well as after inner ear decompression illness requires meticulous consideration of residual damage and possible underlying conditions like vascular right-to-left shunts. This article is based on the new recommendations of the German Undersea and Hyperbaric Medical Society for the assessment of fitness to dive in the otorhinolaryngological field.

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Aktive Mittelohrimplantate – mehr als „nur“ ein Hörgerät

Cited by 4 publications

References 15 publications

An Overview of Nanoparticle Based Delivery for Treatment of Inner Ear Disorders

An Overview of Nanoparticle Based Delivery for Treatment of Inner Ear Disorders

Elektronische Systeme zum Ersatz der defizienten Hörleistung

Tauchtauglichkeit im HNO-Bereich

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