Aktivitas Antiinflamasi Ekstrak Metanol Kulit Batang Sengkuang pada Tikus Wistar yang Diinduksi CFA (Complete Freund’s Adjuvant)

Abstract

One of the plants found in East Kalimantan is the Drancotomelon dao (sengkuang) plant. Previous tests demonstrated the presence of anti-inflammatory activity of D. Dao leaf extract through the reduction of proinflammatory mediators such as TNF-?, IL-1?, and IL-6 which were induced by bacteria. This study aims to determine the anti-inflammatory activity of the methanol extract of the stem bark of the Sengkuang plant in a rat model of rheumatoid arthritis induced by complete freund's adjuvant (CFA) to determine the anti-inflammatory potential of other parts of the sengkuang plant. In this test, rat models of rheumatoid arthritis induced using CFA were divided into 4 treatment groups: negative group (NaCMC), positive group (methyl prednisolone), test group 1 (sengkuang extract 50 mg/KgBW/day), test group 2 (lengkuang extract). 200 mg/KgBB/day). Observation of its anti-inflammatory effect was observed for 14 days. Analysis of the data in this study used a one-way ANOVA with joint thickness dependent variable and zinc dose independent variable. Sengkuang extract at doses of 50 and 200 mg/KgBW/day can reduce joint thickness in animals induced with CFA. The activity of reducing joint thickness showed significance in zinc extract at a dose of 50 mg/KgBW/day on the 14th day. Methanol extract of sengkuang has anti-inflammatory activity in CFA-induced rheumatoid arthritis rats at an optimal dose of 200 mg/KgBW/day, has an anti-inflammatory effect that is good enough to reduce edema volume in arthritis rats.