Aktivitas Antipiretik Ekstrak Etanol Buah Belimbing Wuluh (Averrhoa bilimbi) pada Tikus Putih Jantan (ANTIPYRETIC ACTIVITY OF ETHANOL EXTRACT OF BELIMBING WULUH (AVERRHOA BILIMBI) IN MALE WHITE RAT)

Andriyanto, Andriyanto; Isriyanthi, Ni Made Ria; Sastra, Edwin Ligia; Arif, Ridi; Mustika, Aulia Andi; Manalu, Wasmen

doi:10.19087/jveteriner.2017.18.4.597

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Diuretics are generally able to increase the excretion of urine volume, sodium, and potassium. 52 Potassium levels have an effect on blood pressure if there is an increase in sodium levels in the body, but if sodium levels in the body are normal or less then there is no effect whatsoever on blood pressure. The combination of potassium and sodium levels has a significant relationship with blood pressure when compared to only potassium or sodium levels.…”

Section: Resultsmentioning

confidence: 99%

Diuretic Potency of Belalai Gajah Plants (Clinacanthus nutans (Burm.fil.) Lindau)

Panjaitan¹,

Afandi²,

Aprilia³

2023

Pharmacogn J.

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Hypertension is a major risk factor for cardiovascular disease and chronic kidney disease, the leading cause of death globally. 1 Hypertension or high blood pressure is a condition where after two separate measurements there is an increase in systolic blood pressure ≥140 mmHg and/or diastolic ≥90 mmHg. [2][3][4] If left unchecked, this disease can interfere with the function of other organs such as the heart and kidneys which are vital organs. 5 Symptoms that can be caused in people with hypertension are chest pain, vision problems, ringing in the ears, fatigue, confusion, headache, feeling of heaviness in the back of the neck, vertigo, nosebleeds, dyspnea/ shortness of breath, increased frequency of urine, nausea, sleep apnea, irregular heartbeat regular. 6,7 Factors that cause hypertension are age, family history, being overweight/obese, not being physically active, using tobacco, consuming too much salt (sodium) in the food consumed, too little potassium in the food consumed, consuming too much alcohol. 8 Hypertension often occurs in patients with chronic kidney disease. Hypertension management is needed to control blood pressure and prevent complications. Prevention of hypertension can be done with non-pharmacological efforts such as weight loss and limiting salt intake. As for pharmacological treatment such as therapy with antihypertensive drugs, one of which is diuretics. 7 Diuretics are drugs that can increase urine production due to the excretion of water and electrolytes by the kidneys. 10,11 The accumulation of fluid in the body's tissues is due to the inability of the kidneys to release sodium and water which are excreted together. Diuretics can be used to treat edema, heart failuure, and hypertension. 11 Diuretics can be categorized into three groups: loop diuretics, thiazide diuretics, and potassium-sparing diuretics. [12][13][14] Diuretics are used to improve the composition and volume of fluids in the body, which treats hypertension. 15,16 The mechanism of action of diuretic drugs in lowering blood pressure is by helping the kidneys function in filtering, removing salt and water, which in turn reduces the volume of fluids in the body so that blood pressure also decreases. 7,17 Hypertension is generally treated using synthetic drugs such as furosemide. [18][19][20][21] Furosemide is a loop diuretic that can reduce the reabsorption of sodium produced by the kidneys. Furosemide can inhibit the luminal Na-K-Cl co-transporter in the loop of Henle by binding to the chloride transport channel. In this case, elevated levels of Na, Cl, and K remain in the urine. 22 Long-term use of furosemide is known to cause electrolyte balance disturbances (excessive loss of sodium and potassium),

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Section: Resultsmentioning

confidence: 99%

Diuretic Potency of Belalai Gajah Plants (Clinacanthus nutans (Burm.fil.) Lindau)

Panjaitan¹,

Afandi²,

Aprilia³

2023

Pharmacogn J.

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Secondary metabolite and antipyretic effects of Maja (Crescentia cujete L.) in fever-induced mice

Teodhora

Sholikha

Ania

et al. 2021

Journal of Basic and Clinical Physiology and Pharmacology

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Objectives Fever is a condition when the body experiences an increase in average body temperature above normal level. Maja fruit (Crescentia cujete L.) contains chemical compounds including alkaloid, flavonoid, saponin, and terpenoid, suspected as potential antipyretics. Methods The study aimed to determine the antipyretic activity of ethanol extract of Maja fruit. A total of 25 male white mice of the DDY strain (20–30 g). These treatments divided into three groups with a dose extract of 125, 250, 500 mg/kg BW, standard groups of ibuprofen 400 mg/kg BW, and control groups of CMC-Na 1%. Mice were injected intraperitoneally with 0.1 cc of DPT vaccine-induced. Observations were made by measuring the rectal temperatures of mice using a digital thermometer before DPT vaccine injected or average temperatures, at 0 min (after DPT vaccine injected), 60, 120, 180, and 240 min after administering the test material. The differences between the positive control group, test group, and the negative control group were compared using statistical analysis using one-way variance analysis (ANOVA). The results were considered statistically when the value is (p<0.05). Results The above phytochemical screening results showed that alkaloids, flavonoids, and saponins were present in the Maja fruit powder and extract (C. cujete L.). Based on the results of the statistical analysis obtained, i.e., Group II was not significantly different from Group III and Group IV (p≤0.05) and was significantly different from Group I and Group V. Group I was significantly different from Group II, Group III and Group IV and was not significantly different from Group V (p≥0.05). Conclusions The study showed that Maja fruit mice’s antipyretic behavior at doses of 125, 250, and 500 mg/kg BW was confirmed as a result in reducing the body temperature of male mice. The 500 mg/kg BW dosage of Maja fruit extract (C. cujete L) effectively reduced fever.

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Aktivitas Antipiretik Ekstrak Etanol Buah Belimbing Wuluh (Averrhoa bilimbi) pada Tikus Putih Jantan (ANTIPYRETIC ACTIVITY OF ETHANOL EXTRACT OF BELIMBING WULUH (AVERRHOA BILIMBI) IN MALE WHITE RAT)

Cited by 2 publications

References 5 publications

Diuretic Potency of Belalai Gajah Plants (Clinacanthus nutans (Burm.fil.) Lindau)

Diuretic Potency of Belalai Gajah Plants (Clinacanthus nutans (Burm.fil.) Lindau)

Secondary metabolite and antipyretic effects of Maja (Crescentia cujete L.) in fever-induced mice

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