Aktivitas Antiplasmodium dan Pengaruh Resveratrol terhadap Indeks Organ Mencit yang Terinfeksi Plasmodium berghei ANKA

Hermanto, Faizal; Anisa, Ita Nur; Wahyuningsih, Sri; Alatas, Fikri; Suryani, Suryani; Rachmawan, R Lucky; Haq, Fahmy Ahsanul; Adhary, Fizqi

doi:10.30595/pharmacy.v19i1.12693

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Penelitian sebelumnya melaporkan bahwa resveratrol dapat menghambat pertumbuhan Plasmodium berghei pada model hewan malaria dan menunjukan adanya perbaikan pada organ hati, limpa dan ginjal. (Hermanto et al, 2022). Penelitian potensi resveratrol dalam mengurangi komplikasi malaria berupa malaria serebral masih belum banyak diketahui.…”

Section: Pendahuluanunclassified

“…Temuan kami menunjukkan bahwa resveratrol memiliki persentase penghambatan parasit di atas 30%, sehingga dapat disimpulkan bahwa resveratrol memiliki aktivitas antimalaria. Ini sesuai dengan penelitian sebelumnya bahwa resveratrol memiliki aktivitas antimalaria (Moon and Sim, 2008;Hermanto et al, 2022). 18 Keterangan : Data ditampilkan sebagai rata-rata ± SEM, n=5, a = perbedaan signifikan dibandingkan dengan kontrol (P≤0,05), b = perbedaan signifikan dibandingkan dengan klorokuin (P≤0,05), MS = malaria serebral.…”

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POTENSI RESVERATROL DALAM MENGURANGI KEPARAHAN MALARIA SEREBRAL PADA MENCIT YANG TERINFEKSI Plasmodium berghei ANKA

Hermanto,

Sari Dewi,

Ahsanul Haq

et al. 2023

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Malaria serebral (MS) adalah komplikasi neurologis yang parah dari infeksi Plasmodium falciparum menyebabkan ensefalopati dan bertanggung jawab atas sebagian besar kematian terkait malaria secara global. Tujuan dari penelitian ini adalah mengevaluasi potensi resveratrol dalam mengurangi keparahan malaria serebral pada mencit yang terinfeksi Plasmodium berghei ANKA. Mencit dikelompokkan menjadi beberapa kelompok yaitu kelompok normal (tidak terinfeksi), sedangkan mencit yang terinfeksi P. berghei dan menunjukkan gejala neurologis malaria serebral kemudian dikelompokan menjadi kelompok kontrol; klorokuin 20 mg/kg; resveratrol dosis 25, 50, dan 100 mg/kg. Parameter pengamatan meliputi parasitemia, gejala neurologis, indeks otak, dan evaluasi integritas sawar darah otak. Hasil menunjukkan setelah pemberian resveratrol berbagai dosis terjadi hambatan pertumbuhan parasit, penurunan gejala neurologis, penurunan indeks otak, dan mengurangi kerusakan sawar darah otak akibat infeksi P. berghei dibandingkan dengan kelompok kontrol. Kesimpulan dari penelitian ini adalah resveratrol dapat mengurangi keparahan malaria serebral pada mencit yang terinfeksi P. berghei ANKA. Kata kunci : malaria serebral, Plasmodium berghei, Resveratrol.

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Section: Hasil Dan Pembahasanunclassified

POTENSI RESVERATROL DALAM MENGURANGI KEPARAHAN MALARIA SEREBRAL PADA MENCIT YANG TERINFEKSI Plasmodium berghei ANKA

Hermanto,

Sari Dewi,

Ahsanul Haq

et al. 2023

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Effects of Moringa oleifera Extract as an Immunomodulator of Lymphocyte Cells and Macrophages in BALB/c Mice Infected with Plasmodium berghei

Putu Khrisna Dharma Jaya,

Putu Indah Budi Apsari,

Pande Made Alitta Cantika Putri Nadya Dewi

et al. 2023

FMI

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Highlights: 1. This study assessed the immunomodulatory potential of Moringa oleifera, which may serve as a natural source forantimalarial treatment.2. Moringa oleifera extract can act as an immunomodulator due to its suppressive effect on Plasmodium berghei infection. Abstract Malaria is an infectious disease caused by protozoa of the genus Plasmodium. In Indonesia, this disease remains a health concern that must be resolved. Due to its high prevalence in eastern Indonesia, it is a challenge to eradicate this disease. Moringa oleifera contains various substances that are believed to have antimalarial activity. This study aimed to determine the effectiveness of Moringa oleifera leaf extract in increasing immune cells and eradicating parasites by using mice infected with Plasmodium berghei. The research was conducted in vivo on BALB/c strain mice (n=40) that were already infected with Plasmodium berghei. Moringa oleifera leaf extract at 25%, 50%, and 75% concentrations was administered orally every day to the mice, while a peripheral blood smear was performed to evaluate parasitemia levels and macrophage activation. A complete blood count was also performed after all tests on the mice were completed. Statistical analysis was performed using the one-way analysis of variance (ANOVA) test with a=0.05 and 95% confidence interval (CI). The results showed that the administration of Moringa oleifera leaf extract at 25%, 50%, and 75% concentrations caused varying degrees of parasitemia compared to the negative group (p<0.05). The group that received the extract at 50% concentration differed significantly from the control groups in the number of activated macrophages. The results of the complete blood count indicated immunomodulatory effects through the presence of diverse immune cell types. In conclusion, Moringa oleifera leaf extract suppresses Plasmodium berghei infection and enhances immune cell stimulation.

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Resveratrol Reduce the Severity of Anemia and Thrombocytopenia in Plasmodium berghei ANKA-Infected Mice

Hermanto,

Refiani,

Ahsanul Haq

2023

JFIKI

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Background: Malaria is an infectious disease with a high mortality rate. One of the complications of malaria is blood disorders. Hematological disorders such as anemia and thrombocytopenia are common in malaria infection. Resveratrol has been reported to have antimalarial activity. Objective: This study aimed to evaluate the effect of resveratrol in reducing the severity of anemia and thrombocytopenia in Plasmodum berghei-infected mice. Methods: The study began with parasite inoculation in mice. After the mice were infected, and randomly grouped into negative control, chloroquine 20 mg/kg (positive control), and resveratrol with doses 25, 50, and 100 mg/kg. The mice's blood profile was measured on day 0 and day 4 using a hematology analyzer. Results: The results showed that after administration of resveratrol at various doses, the number of RBC, hemoglobin, hematocrit and platelets was higher than the control. Conclusion: It can be concluded that resveratrol can reduce the severity of anemia and thrombocytopenia in mice infected with P. berghei.

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Aktivitas Antiplasmodium dan Pengaruh Resveratrol terhadap Indeks Organ Mencit yang Terinfeksi Plasmodium berghei ANKA

Cited by 3 publications

References 9 publications

POTENSI RESVERATROL DALAM MENGURANGI KEPARAHAN MALARIA SEREBRAL PADA MENCIT YANG TERINFEKSI Plasmodium berghei ANKA

POTENSI RESVERATROL DALAM MENGURANGI KEPARAHAN MALARIA SEREBRAL PADA MENCIT YANG TERINFEKSI Plasmodium berghei ANKA

Effects of Moringa oleifera Extract as an Immunomodulator of Lymphocyte Cells and Macrophages in BALB/c Mice Infected with Plasmodium berghei

Resveratrol Reduce the Severity of Anemia and Thrombocytopenia in Plasmodium berghei ANKA-Infected Mice

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