Aktivitas Sitotoksik Ekstrak Etanol Kulit Buah Pinang (Areca catechu) dan Daun Kayu Manis (Cinnamomum burmanni)

Herdwiani, Wiwin; Aa, Soemardji; Elfahmi, Elfahmi; Tan, Mi; Nabila, Kausain Akther; Anita, Kanojia

doi:10.31001/jfi.v15i1.348

Cited by 2 publications

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“…IC 50 MCF-7 values can be seen in Table 1. Based on the IC50 value that has been obtained, it can be seen that the methanol extract has a value of 3.9861 μg / mL (very active), meaning that the mixed compound shows anticancer activity that can inhibit cell proliferation and is very potential as a compreventive agent, compounds that can prevent the carcinogenesis process which triggers cancer (Meiyanto, 2008). Picture 1 shows a graph of MCF-7 cell mortality percentage due to treatment of methanol extract samples.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxicity Test of Methanol Extract of Belajang Susu (Scindapsus pictus Hassk.) Against MCF-7 Breast Cancer Cells

Salempa,

Muharram,

Jumadi

et al. 2022

IJFS

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Abstract. Belajang Susu Plant (Scindapsus pictus Hassk.) is a species of the genus Scindapsus including the Araceae family which has been traditionally used by the Mambi people for medicine. Plants from the genus Scindapsus contain active compounds such as calcium oxalate, flavonoids sulfate and a mixture of flavones and flavonols sulfate which can be used as anti-inflammatory, analgesic, antioxidant, anticancer and anti-tumor. This study aims to determine the potential of methanol extract of Scindapsus pictus Hassk. as an anticancer. Extraction was carried out by maceration with methanol and then tested for cytotoxicity against MCF-7 cancer cells. The results showed that the methanol extract of Scindapsus pictus Hassk. was very active against MCF-7 breast cancer cells with an IC50 value of 3.9861 μg / mL. Keywords: Belajang susu, Scindapsus pictus Hassk., MCF-7The first section in your paper

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Section: Resultsmentioning

confidence: 99%

Cytotoxicity Test of Methanol Extract of Belajang Susu (Scindapsus pictus Hassk.) Against MCF-7 Breast Cancer Cells

Salempa,

Muharram,

Jumadi

et al. 2022

IJFS

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“…Uji kandungan flavonoid menggunakan fase gerak Butanol-Asam Asetat-Air (3:1:1) menunjukkan hasil positif. [28] 5 Haeria dkk.…”

Section: Pasaribu Dkk (2014)unclassified

“…Kemudian kayu manis yang menunjukkan hasil positif flavonoid pada pengujian menggunakan fase gerak Butanol-Asam Asetat-Air (3:1:1), dan yang terakhir adalah daun kelor yang biasanya dianggap sebagai tanaman liar ternyata juga memiliki kadar flavonoid sebesar 245,771 mg/L atau berkisar antara 7,79 mg/g. [28] 4. Kesimpulan Infeksi HIV selalu menjadi pokok permasalahan kesehatan utama di dunia maupun di Indonesia.…”

Section: Pasaribu Dkk (2014)unclassified

Potensi Flavonoid Bahan Alam Sebagai Anti-HIV Guna Mengatasi Darurat Infeksi HIV di Indonesia

Azriz,

Ibrahim,

Maulana

et al. 2024

SCRIPTA SCORE Sci Med J.

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Background: Human Immunodeficiency Virus (HIV) infection is an unresolved health problem in various countries. Indonesia is rich in various potential natural resources and is able to support the development of HIV therapy through the use of bioactive components from plants, one of which is flavonoid compounds which need to be investigated for their potential anti-HIV activity. Objective: To determine the anti-HIV potential of natural compound flavonoids. Method: The method used is a narrative literature review, with literature collection obtained from PubMed, ScienceDirect and Google Scholar. The selected articles are those published in the last ten years (2013-2022) and full text is available. Result and Discussion: 24 articles included related to flavonoid and HIV. Indonesia is in an emergency situation for HIV infection, antiretroviral drugs (ARV) can only inhibit the development of the virus, but do not kill the virus directly. The antiviral potential of flavonoid compounds makes this substance an opportunity to be studied in HIV infection. The flavonoid subclasses myricetin, herbacitrin, and chalcone have the best anti-HIV activity. The natural ingredient that has the highest flavonoid such as sea fern spores, dragon fruit with a content of 0.14 - 0.15 mg/g, Moringa leaves with a content of 7.79 mg/g, and cinnamon with a fairly high content. Conclusion: Flavonoids have anti-HIV potential with different mechanisms according to the type of flavonoid compounds contained. Flavonoids are mostly contained in sea fern spores, and are also found in dragon fruit, cinnamon and Moringa leaves, which are natural ingredients that are easily available every day. Latar Belakang: Infeksi Human Immunodeficiency Virus (HIV) merupakan masalah kesehatan yang belum terselesaikan pada berbagai negara di dunia. Indonesia merupakan negara yang kaya akan berbagai sumber daya alam yang potensial dan mampu mendukung pengembangan terapi HIV melalui pemanfaatan komponen bioaktif dari tumbuhan, salah satunya adalah senyawa flavonoid yang perlu ditelitipotensi aktivitas anti-HIVnya. Tujuan: Mengetahui potensi anti-HIV dari senyawa flavonoid bahan alam Metode: Metode yang digunakan adalah tinjauan literatur naratif, dengan pengumpulan literatur dilakukan melalui database PubMed, ScienceDirect, dan Google Scholar. Artikel yang dipilih adalah yang terbit sepuluh tahun terakhir (2013-2022) dan tersedia full text. Pembahasan: 24 artikel didapatkan membahas flavonoid dan kaitannya pada HIV. Indonesia berada dalam kondisi darurat infeksi HIV, obat antiretroviral (ARV) hanya dapat menghambat perkembangan virus, namun tidak membunuh virus secara langsung. Adanya potensi antivirus dari senyawa flavonoid menjadikan zat ini berpeluang untuk diteliti pada penyakit infeksi HIV. Flavonoid subkelas myricetin, herbacitrin, dan kalkon memiliki aktivitas anti-HIV yang paling baik. Bahan alam yang mempunyai kandungan flavonoid tertinggi di antaranya spora paku laut, buah naga dengan kandungan sebesar 0,14 – 0,15 mg/g, daun kelor dengan kandungan sebesar 7,79 mg/g, dan kayu manis dengan kandungan cukup tinggi. Kesimpulan: Flavonoid memiliki potensi anti-HIV dengan mekanisme yang berbedabeda sesuai dengan jenis senyawa flavonoid yang terkandung. Flavonoid paling banyak terkandung dalam spora paku laut, serta juga ditemukan pada buah naga, kayu manis, dan daun kelor yang merupakan bahan alam yang mudah didapatkan sehari-hari.

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Aktivitas Sitotoksik Ekstrak Etanol Kulit Buah Pinang (Areca catechu) dan Daun Kayu Manis (Cinnamomum burmanni)

Cited by 2 publications

References 0 publications

Cytotoxicity Test of Methanol Extract of Belajang Susu (Scindapsus pictus Hassk.) Against MCF-7 Breast Cancer Cells

Cytotoxicity Test of Methanol Extract of Belajang Susu (Scindapsus pictus Hassk.) Against MCF-7 Breast Cancer Cells

Potensi Flavonoid Bahan Alam Sebagai Anti-HIV Guna Mengatasi Darurat Infeksi HIV di Indonesia

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