Aktywne formy witaminy D a zdrowie

Piotrowska, Anna; Czerwińska-Ledwig, Olga; Podhorecki, Adam; Pilch, Wanda

doi:10.20883/ppnoz.2019.68

Cited by 3 publications

(4 citation statements)

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“…A signi cant increase in the concentration of 25(OH)D 3 , which was statistically signi cant, which took place in our study was most likely associated with an increase in exposure to UV radiation [30]. Increased exposure to UV radiation intensi es skin synthesis, which is the main source of vitamin D, apart from that taken with food [31].…”

Section: Vitamin 25(oh)dsupporting

confidence: 46%

“…The ingested inactive form of vitamin D is metabolized in the liver to 25(OH)D 3 (calcidiol) as a result of hydroxylation, then in the proximal tubules in the kidneys another OH group is added leading to the formation of 1,25(OH) 2 D (calcitriol). The transformation of vitamin D in the body and the nature of its active metabolites on target tissues allows for the classi cation of vitamin D as a pleiotorphic hormone [31]. Its reduced concentration is associated with the development of noncommunicable diseases (NCD) and various types of cancers [30].…”

Section: Vitamin 25(oh)dmentioning

confidence: 99%

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Effect of a 6-week Cycle of Nordic Walking Training on Vitamin 25(OH)D3 Calcium-phosphate Metabolism and Muscle Damage in Multiple Myeloma Patients

Czerwińska-Ledwig¹,

Pilch²,

Gradek³

et al. 2022

Preprint

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Introduction: Multiple myeloma (MM) is a hematological malignancy affecting older adults (median age 70 years). One of the most common myeloma defining events is the development of symptomatic lytic bone disease which leads to fractures and immobilization. It is caused by disturbances in bone metabolism affecting calcium-phosphate balance. Treatment of the bone disease and the underlying malignancy results in disease and symptom control.Objectives: In this study, the impact of a 6-week Nordic walking (NW) exercise program on blood parameters related to calcium-phosphate metabolism and damage of skeletal muscles was assessed. Patients and methods: 28 subjects with MM in remission stage, without cytostatic treatment were enrolled and completed the study: 15 in the training group (NW) and 13 in control group (CG). All patients were supplemented with vitamin D3, calcium carbonate daily and received zoledronic acid every 4 weeks. Two venous blood samples were drawn – before and after the 6 weeks of training sessions – to assess the serum concentrations of vitamin 25(OH)D3, inorganic phosphorus, total calcium, myoglobin, and lactate dehydrogenase (LDH).Results: Patients from the NW group showed a statistically significant decrease in mean serum myoglobin concentration (p=0.018) and increase in 25(OH)D3 (p<0.001) and total Ca (p=0.001) concentrations. In the NW group, there was a correlation between the changes in myoglobin, phosphorus, 25(OH)D3 and Ca concentrations after 6 weeks.Conclusions: NW training is a safe and beneficial form of physical exercise for patients with MM without inducing muscle damage. NW performed outside during Spring-Summer season improves serum vitamin 25(OH)D3 concentration.

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Section: Vitamin 25(oh)dsupporting

confidence: 46%

Section: Vitamin 25(oh)dmentioning

confidence: 99%

Effect of a 6-week Cycle of Nordic Walking Training on Vitamin 25(OH)D3 Calcium-phosphate Metabolism and Muscle Damage in Multiple Myeloma Patients

Czerwińska-Ledwig¹,

Pilch²,

Gradek³

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…A significant increase in the concentration of 25(OH)D 3 , which was statistically significant, took place in our study and was most likely associated with an increase in exposure to UV radiation [ 41 ]. Increased exposure to UV radiation intensifies skin synthesis, which is the main source of vitamin D, apart from that taken with food [ 45 ]. According to the data supplied by the Institute of Meteorology and Water Management (Warsaw, Poland) in the study period, the sum of insolation for the city of Kraków and suburban areas in May was in the range of 140–160 h, in June 310–330 h, and 220–240 in July.…”

Section: Discussionmentioning

confidence: 99%

Effect of a 6-Week Cycle of Nordic Walking Training on Vitamin 25(OH)D3, Calcium-Phosphate Metabolism and Muscle Damage in Multiple Myeloma Patients–Randomized Controlled Trial

Czerwińska-Ledwig

Piotrowska

Gradek

et al. 2022

JCM

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Introduction: Multiple myeloma (MM) is a hematological malignancy affecting older adults. One of the most common myeloma-defining events is the development of symptomatic lytic bone disease. The serum concentrations of calcium (Ca), inorganic phosphorus (P), and vitamin 25(OH)D3 in the serum reflect bone metabolism. An enzyme lactate dehydrogenase (LDH) is a marker of muscle damage, but its serum activity also has an important prognostic value in MM. Myoglobin (Mb) is a small protein present in muscles; its serum level increases when myocytes are damaged. Objectives: In this study, the impact of a 6-week Nordic walking (NW) exercise program on blood parameters related to calcium-phosphate metabolism and damage of skeletal muscles was assessed. Patients and methods: A total of 33 patients with MM in the remission stage, without cytostatic treatment, were allocated and randomly assigned to one of two groups: 17 in the training group (NW) and 16 in the control group (CG). All patients were supplemented per os with vitamin D3 and calcium carbonate daily and received zoledronic acid every 4 weeks (intravenous). Nordic walking training sessions took place 3 times a week for 6 weeks, 1 h each. Blood samples were drawn before and after the 6 weeks of training sessions to assess the serum concentrations of vitamin 25(OH)D3, P, Ca, Mb, and LDH. Results: Patients from the NW group showed a statistically significant decrease in mean serum myoglobin concentration (p = 0.018) and an increase in 25(OH)D3 (p < 0.001) and total Ca (p = 0.001) concentrations. There were no statistically significant changes in the results obtained in CG. Between groups, after 6 weeks, Mb serum concentration was significantly lower in NW (p = 0.041), and 25(OH)D3 was higher (p < 0.001) compared to CG. There was a correlation between the changes in myoglobin, phosphorus, 25(OH)D3, and Ca concentrations after 6 weeks. Conclusions: NW training is a safe and beneficial form of physical exercise for patients with MM without inducing muscle damage. NW performed outside improves serum vitamin 25(OH)D3 concentration.

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“…Due to sunlight, the synthesis of vitamin D 3 is induced in the skin, which has broad beneficial effects on the body [2]. The positive effects of UV radiation are also used in the treatment of certain dermatological diseases such as psoriasis [3] or vitiligo [4].…”

Section: Introductionmentioning

confidence: 99%

Survey of cosmetologists’ knowledge of photoallergenic and phototoxic substances

Lulek,

Grodecka,

Piotrowska

2023

Aesth Cosmetol Med

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Phototoxic and photoallergic reactions induced by ultraviolet A radiation belong to the group of exogenous photodermatoses. To induce changes in addition to sunlight, the presence of a photosensitizer is essential. These can be both externally applied and systemically ingested substances: drugs and supplements, plants, cosmetics, essential oils. The article aimed to assess cosmetologists’ knowledge of phototoxic and photoallergic substances. The study was carried out in a group of 103 cosmetologists based on an original questionnaire survey. Statistically significant differences were found in the level of knowledge between those with a master’s degree and a bachelor’s degree. The groups also differed in their willingness to expand their knowledge.

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Aktywne formy witaminy D a zdrowie

Cited by 3 publications

References 0 publications

Effect of a 6-week Cycle of Nordic Walking Training on Vitamin 25(OH)D3 Calcium-phosphate Metabolism and Muscle Damage in Multiple Myeloma Patients

Effect of a 6-week Cycle of Nordic Walking Training on Vitamin 25(OH)D3 Calcium-phosphate Metabolism and Muscle Damage in Multiple Myeloma Patients

Effect of a 6-Week Cycle of Nordic Walking Training on Vitamin 25(OH)D3, Calcium-Phosphate Metabolism and Muscle Damage in Multiple Myeloma Patients–Randomized Controlled Trial

Survey of cosmetologists’ knowledge of photoallergenic and phototoxic substances

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