Akute Myokarditis und Kardiomyopathie bei der Lyme-Borreliose

Scheffold, N; Sucker, Christoph; Bergler‐Klein, Jutta; Kaag, Norbert; Cyran, J.

doi:10.1007/s003920070158

Cited by 6 publications

(1 citation statement)

References 31 publications

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“…Opinion remains divided on the role of borreliae in cases of chronic ‘idiopathic’ dilated cardiomyopathy (IDC) 59 73 74. Stanek et al demonstrated positive B burgdorferi serology in 26.4% of 72 patients with IDC 75.…”

Section: Late Lbmentioning

confidence: 99%

Lyme disease in the United Kingdom

Dubrey

Bhatia

Woodham

et al. 2013

Postgraduate Medical Journal

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Lyme disease, while still an uncommon disease in the UK, is on the increase. Case numbers have increased by 3.6-fold since 2001, with over 950 cases reported by the Health Protection Agency (HPA) in 2011, compared with less than 500 cases annually pre-2004. HPA indications of the true incidence are suggested to be closer to 3000 cases/year, of which around 82% of cases are indigenously acquired. Three genospecies, Borrelia burgdorferi sensu stricto, Borrelia afzelli and Borrelia garinii, represent the predominant pathogenic variants in the UK. Erythema migrans is the commonest manifestation, occurring in 60%-91% of cases. In the UK, neuroborelliosis is the most common complication, while myocarditis is unusual, and death from either conduction disease or carditis is extremely rare. The role of Borrelia infection in chronic dilated cardiomyopathy in the UK remains unproven. Controversy over the existence of either 'chronic Lyme disease' and/or 'post-Lyme disease syndrome' continues unabated. National medical societies, patient advocacy groups, insurance companies, lawyers, doctors, the private health medical sector and scientific journals have all become embroiled in this bitter controversy. New developments include diagnostic tests able to detect Lyme disease at an earlier stage, shorter durations of antibiotic therapy and potential advances in vaccines against Borrelia.

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Section: Late Lbmentioning

confidence: 99%

Lyme disease in the United Kingdom

Dubrey

Bhatia

Woodham

et al. 2013

Postgraduate Medical Journal

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Das Herz bei viralen, bakteriellen und parasitären Infektionen

Maisch

Alter

et al. 2007

Internist

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The heart can be the primary target for a viral, bacterial or parasitic infection (primary myocarditis/inflammatory cardiomyopathy). It can also participate in the "collateral damage" due to toxins, chemo- and cytokines, autoreactive antibodies or the native and acquired immune response through T- and B-cells, monocytes and macrophages (secondary myocarditis/inflammatory cardiomyopathy), when it is not the dominant organ of the disease. Infective agents show remarkable organ specificity: viral infections, toxic and autoreactive processes affect primarily the myocardium and the pericardium, whereas bacterial infections prefer endothelial surfaces and cause endocarditis and, less frequently, pericarditis. They are even discussed as part of the inflammatory process involved in coronary artery disease. Infective agents and their adequate diagnosis and treatment are discussed for these clinical entities according to current guidelines and clinical pathways.

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Entzündliche Herzerkrankungen bei primär extrakardialen Erkrankungen

2007

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As systemic immunological disorders, internal diseases in gastroenterology, rheumatology and infectiology can, in addition to the bowels, potentially involve the musculo-skeletal system, the immunological system and heart structures. All structures and functions of the heart can be affected. Pericarditis in lupus erythematosus and chronic inflammatory bowel disease, myocarditis in HIV infection and lyme disease are examples of cardiac manifestations of internal diseases. The pathogenetic causes can be manifold, such as direct cytotoxic effects in HIV or Borrelia burgdorferi infections, induced vasculitis and local activation of coagulation factors as in lupus erythematosus or chronic inflammatory bowel disease. Improved treatment options have led to more long-lasting courses of internal diseases, such as in infectious diseases, lupus erythematosus and chronic inflammatory bowel disease, thus cardiovascular complications such as pericarditis and myocarditis gain increasing importance as a consequence of chronic disease and therapy-related damage.

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Akute Myokarditis und Kardiomyopathie bei der Lyme-Borreliose

Cited by 6 publications

References 31 publications

Lyme disease in the United Kingdom

Lyme disease in the United Kingdom

Das Herz bei viralen, bakteriellen und parasitären Infektionen

Entzündliche Herzerkrankungen bei primär extrakardialen Erkrankungen

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