Akute retinale Nekrose aus Virologensicht

Rautenberg, Peter; Grancicova, Livia; Hillenkamp, Jost; Nölle, Bernhard; Roider, Johann; Fickenscher, Helmut

doi:10.1007/s00347-009-2048-4

Cited by 8 publications

(5 citation statements)

References 93 publications

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“…Острый некроз сетчатки (ОНС) является редким (1 случай на 1-2 млн населения в год) заболеванием [1,2], однако среди больных с тяжелыми увеитами, по данным отдела патологии сетчатки и зрительного нерва МНИИ ГБ им. Гельмгольца, встречается в 8,9 % случаев [3].…”

Section: статья номераunclassified

“…В 1982 г. была установлена герпес-вирусная этиология заболевания [8,9]. Наиболее частой причиной ОНС является вирус варицелла-зостер (ВВЗ) (до 70 % случаев) и вирусы простого герпеса (ВПГ) 1-го или 2-го типа (до 30 % случаев), режецитомегаловирус (ЦМВ) и вирус Эпштейна -Барр (ВЭБ) [2,[8][9][10].…”

Section: статья номераunclassified

“…Лечение ОНС начинают с интенсивной противовирусной и противовоспалительной терапии. Раннее использование противовирусных средств является важнейшей составляющей успешного лечения этого заболевания [2,10]. Противовирусные препараты (ацикловир, валацикловир, ганцикловир) применяются внутривенно, перорально и интравитреально [10,11].…”

Section: статья номераunclassified

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Results of surgical treatment of acute retinal necrosis

Нероев¹,

Ilyukhin²,

Федотов³

et al. 2018

ROJ

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Ðåçóëüòàòû õèðóðãè÷åñêîãî ëå÷åíèÿ îñòðîãî íåêðîçà ñåò÷àòêè Â.Â. Íåðîåâ -÷ë.-êîðð. ÐÀÍ, ä-ð ìåä. íàóê, ïðîôåññîð, äèðåêòîð Ï.À. Èëþõèí -êàíä. ìåä. íàóê, íàó÷íûé ñîòðóäíèê îòäåëà ïàòîëîãèè ñåò÷àòêè è çðèòåëüíîãî íåðâà Ð.À. Ôåäîòîâ -àñïèðàíò îòäåëà ïàòîëîãèè ñåò÷àòêè è çðèòåëüíîãî íåðâà Â.Ý. Òàíêîâñêèé -ä-ð ìåä. íàóê, ñòàðøèé íàó÷íûé ñîòðóäíèê îòäåëà ïàòîëîãèè ñåò÷àòêè è çðèòåëüíîãî íåðâà

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Section: статья номераunclassified

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Results of surgical treatment of acute retinal necrosis

Нероев¹,

Ilyukhin²,

Федотов³

et al. 2018

ROJ

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“…Roughly one and two thirds of cases are caused by reactivation of HSV and VZV, respectively. Clinical course, treatment options and therapy outcome of this severe disease were recently reviewed [134–136]. The vasculitis, retinal necrosis, and intraocular inflammation start in the periphery and rapidly progress circumferentially, mostly affecting nonimmunocompromised patients at a frequency of 0.5 cases per 1 million.…”

Section: The Risk Factor Model—clinical Implications Of Herpes Virmentioning

confidence: 99%

The Role of Plasmacytoid Dendritic Cells in Innate and Adaptive Immune Responses against Alpha Herpes Virus Infections

Schuster

Boscheinen

Tennert

et al. 2011

Advances in Virology

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In 1999, two independent groups identified plasmacytoid dendritic cells (PDC) as major type I interferon- (IFN-) producing cells in the blood. Since then, evidence is accumulating that PDC are a multifunctional cell population effectively coordinating innate and adaptive immune responses. This paper focuses on the role of different immune cells and their interactions in the surveillance of alpha herpes virus infections, summarizes current knowledge on PDC surface receptors and their role in direct cell-cell contacts, and develops a risk factor model for the clinical implications of herpes simplex and varicella zoster virus reactivation. Data from studies involving knockout mice and cell-depletion experiments as well as human studies converge into a “spider web”, in which the direct and indirect crosstalk between many cell populations tightly controls acute, latent, and recurrent alpha herpes virus infections. Notably, cells involved in innate immune regulations appear to shape adaptive immune responses more extensively than previously thought.

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“…However, HLA-Aw33, -B44 and -DRw6 antigens were more commonly expressed among Japanese patients, and fulminant ARN is associated with HLA-DR9 [7,12,13]. …”

Section: Introductionmentioning

confidence: 99%

Clinical Manifestation of Self-Limiting Acute Retinal Necrosis

et al. 2014

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BackgroundThe purpose of this paper was to present a case series of self-limiting, peripheral acute retinal necrosis and to demonstrate efficacy of treatment with valacyclovir in patients resistant to acyclovir. The diagnosis was made on ophthalmoscopic examination and positive serum tests for herpes viruses.Material/MethodsTen patients (6F and 4M) aged 19–55 years were diagnosed and treated for self-limiting acute retinal necrosis (ARN). The following endpoints were reported: visual outcomes, clinical features, disease progression, treatment, and complications. Patients received only symptomatic treatment because they did not consent to vitreous puncture.ResultsPeripheral, mild retinitis was diagnosed in all eyes at baseline. Initially, all patients were treated with systemic acyclovir (800 mg, 5 times a day), prednisone (typically 40–60 mg/day), and aspirin in an outpatient setting. In 6 patients, treatment was discontinued at 6 months due to complete resolution of the inflammatory process. Four patients with immune deficiency showed signs and symptoms of chronic inflammation. Two patients did not respond to acyclovir (2 non-responders); however, those patients were successfully treated with valacyclovir. Complete resolution of inflammatory lesions was observed in 8 patients. In 2 patients, the disease progressed despite treatment – 1 female patient after kidney transplant who stopped the prescribed medications, and 1 male patient with SLE and antiphospholipid syndrome who experienced breakthrough symptoms on-treatment. He died due to cerebral venous sinus thrombosis. Neurological complications (encephalitis and meningitis) were observed in 2 female patients. Prophylactic laser photocoagulation was performed in 1 subject.ConclusionsA series of cases of self-limiting acute retinal necrosis (ARN) is presented. This clinical form of ARN can resemble toxoplasmic retinitis in some cases. Oral antiviral medications provide an effective alternative to intravenous formulations in patients with self-limiting ARN. Retinitis is associated with the risk of encephalitis.

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Akute retinale Nekrose aus Virologensicht

Cited by 8 publications

References 93 publications

Results of surgical treatment of acute retinal necrosis

Results of surgical treatment of acute retinal necrosis

The Role of Plasmacytoid Dendritic Cells in Innate and Adaptive Immune Responses against Alpha Herpes Virus Infections

Clinical Manifestation of Self-Limiting Acute Retinal Necrosis

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