Akute t�dliche Vergiftung mit ?Nikotin 95/98%?

How much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century

“…Several detailed reviews are available on fatal nicotine intoxications caused by either suicidal intent or accidents, latter mainly resulting from misusage of nicotine-containing solutions marketed as pesticides (Esser and Kühn 1933; Larson et al 1961; Maehly and Bonnichsen 1963; Tiess and Nagel 1966; Hayes 1982; Corkery et al 2010; Solarino et al 2010). The postmortem data reviewed by Maehly and Bonnichsen (1963) and more recently by Corkery et al (2010) and Solarino et al (2010) revealed minimal nicotine blood levels of 2 mg/L, but rapid decline of blood nicotine after death (Sanchez et al 1996) may have led to underestimation of the actual lethal concentration in delayed autopsies.…”