Al+3 ion cross-linked and acetalated gellan hydrogel network beads for prolonged release of glipizide

Maiti, Sabyasachi; Ranjit, Somdipta; Mondol, Ranjit; Ray, Somasree; Sa, Biswanath

doi:10.1016/j.carbpol.2011.02.010

Cited by 106 publications

(46 citation statements)

References 41 publications

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“…Fig. 6 transport mechanism (Ritger and Peppas, 1987 with subsequent relaxation of the side chains (Maiti et al, 2011). 411 For the formula A/TA 1:1, n was closer to 1, indicating that 412 microbeads behave as a zero-order release system (Sezer and 413 Akbu ga, 1995).…”

mentioning

confidence: 94%

Development of mucoadhesive microbeads using thiolated sodium alginate for intrapocket delivery of resveratrol

Kassem

Farid

Issa

et al. 2015

International Journal of Pharmaceutics

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mentioning

confidence: 94%

Development of mucoadhesive microbeads using thiolated sodium alginate for intrapocket delivery of resveratrol

Kassem

Farid

Issa

et al. 2015

International Journal of Pharmaceutics

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“…Food and Drug Administration (FDA) suggested safe use of gellan polysaccharide as food additive for human consumption. Ionotropically-gelled hydrogel beads of gellan have been studied extensively in achieving prolonged release for a variety of drugs [22][23][24]. The hydrogel particles offer advantages over single units because they distribute more uniformly in the gastrointestinal tract, prevent exposure to high drug concentration and thereby reduce the local tissue irritation [25].…”

Section: Introductionmentioning

confidence: 99%

Cetyl gellan copolymer micelles and hydrogels: In vitro and pharmacodynamic assessment for drug delivery

Kundu¹,

Maiti²

2015

International Journal of Biological Macromolecules

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“…The diffractogram patterns of pure GLP showed the important crystallographic characteristics at different scattering angles from 5°to 30°(2θ) with different signal intensities (49). The diffractogram corresponding to pure CP934P showed a halo pattern of its amorphous nature.…”

Section: Solid-state Studiesmentioning

confidence: 99%

Study of the Mucoadhesive Potential of Carbopol Polymer in the Preparation of Microbeads Containing the Antidiabetic Drug Glipizide

2015

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Abstract. The present investigation was aimed at exploitation of the mucoadhesive potential of carbopol 934P polymer in developing microbeads of glipizide (GLP) for its effectivity in controlling blood sugar in diabetic patients. Various batches of GLP beads were prepared by an emulsion-solvent evaporation technique using the release-retarding polymer carbopol and subjected to a systematic evaluation such as physical characterization, ex vivo mucoadhesion, hydration and erosion test, and in vitro drug release; and instrumental and in vivo studies were performed with the best formulation. The highest yield and loading efficiency were observed as 94 and ∼90%, respectively. The mean particle size of the microbeads ranged from 832 to 742 μm. The oval shape of the microbeads with slight roughness was apparent in the SEM micrograph. The release period was extended till 18 h. In vitro release of the drug from the beads followed the diffusion and erosion mechanism. In the oral glucose tolerance test (OGTT), there is a significant (p<0.01) reduction in fasting blood glucose levels in Wistar rat and guinea pig in comparison with that using the marketed product. Results indicated that process parameters-drug-polymer ratio, concentration of the surfactant, and stirring speed-controlled the various characteristics of the microparticles. The mucoadhesivity test ensured strong adherence of the beads to the mucosal membrane in pH 1.2 for a prolonged period. Owing to the mucoadhesivity of carbopol 934P, prolonged release of GLP and reduction of fasting sugar in the animal model were observed to a satisfactory level, and thus, management of diabetes in a better manner is expected with this new formulation.

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Al+3 ion cross-linked and acetalated gellan hydrogel network beads for prolonged release of glipizide

Cited by 106 publications

References 41 publications

Development of mucoadhesive microbeads using thiolated sodium alginate for intrapocket delivery of resveratrol

Development of mucoadhesive microbeads using thiolated sodium alginate for intrapocket delivery of resveratrol

Cetyl gellan copolymer micelles and hydrogels: In vitro and pharmacodynamic assessment for drug delivery

Study of the Mucoadhesive Potential of Carbopol Polymer in the Preparation of Microbeads Containing the Antidiabetic Drug Glipizide

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