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Yadav, Rajesh Kumar; Jain, Gourav

doi:10.1023/a:1006784224191

Cited by 31 publications

(5 citation statements)

References 16 publications

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“…They are also used to relieve constipation and to treat jaundice, biliousness, skin disease and swollen throat. 10 The plant has been reported to possess various pharmacological activities such as anticancer, 11 antifertility, 12 antifungal, 13 antihelmintic, 14 antihyperlipidemic, 15 anti-inflammatory, 16 Antipyretic activity, 17 antioxidant, 18 antimicrobial, 19 hepatoprotective, 20 immunomodulatory, 21 and laxative effects. 22 Phytochemical studies revealed that the edible fruit tissue of the Indian laburnum is a rich source of potassium, calcium, iron, manganese and also of aspartic acid, glutamic acid and lysine amino acids.…”

Section: Determination Of Blood Glucosementioning

confidence: 99%

Evaluation of Antidiabetic Activity of Hydroalcoholic Extract of Cassia fistula Linn. pod in Streptozotocin-Induced Diabetic Rats

Jangir¹,

Jain²

2017

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Background: Diabetes mellitus (DM) is a global health problem and the incidence of DM is increasing at alarming rate all over the world. Many Indian medicinal plants have been reported to possess potential antidiabetic activity and could play important role in the management diabetes. Objective: The present study aimed to evaluate antidiabetic activities of 70% ethanolic extract of Cassia fistula pod in streptozotocin-induced diabetic rats. Materials and Methods: Diabetes was induced in male Wistar rats by single intraperitoneal injection of streptozotocin (60 mg/kg b.wt.). The diabetic rats were administered orally with C. fistula pod extract at three different doses (100, 250 and 500 mg/kg b.wt./day) for 60 days. The results were compared with standard drug glibenclamide (5 mg/kg b.wt./day) treated rats. Results: The streptozotocin treated diabetic control rats showed a significant increase in the blood glucose and glycosylated hemoglobin (HbA1c) levels with a concomitant decrease in the body weight and glycogen content in the liver as compared to normal control rats. Oral administration of C. fistula pod extract (100, 250 and 500 mg/kg b.wt./day) or glibenclamide for 60 days showed significant reduction in the blood glucose and HbA1c levels and an elevation in the body weight and hepatic glycogen content as compared to diabetic control rats. Furthermore, treatment with extract (500 mg/kg b.wt.) also showed improvement of oral glucose tolerance test (OGTT) in diabetic rats. These results were comparable to glibenclamide. Conclusion:The results of present study showed that C. fistula pod extract possess significant antihyperglycemic activity and supports the traditional use of C. fistula pod for the treatment of diabetes mellitus. Key words: Antidiabetic, Blood glucose, Cassia fistula, Glycogen, Glycosylated hemoglobin, Streptozotocin. Cite this article : Jangir RN, Jain GC. Evaluation of antidiabetic activity of hydroalcoholic extract of Cassia fistula Linn. pod in streptozotocin-induced diabetic rats. Pharmacog J. 2017;9(5):599-606. Ram Niwasphytochemicals. Many Indian medicinal plants have been found to be useful in the management of diabetes acting though variety of mechanisms. Medicinal plants provide better alternatives as they are less toxic, easily available and affordable and many of the currently available drugs have been derived directly or indirectly from them. 6,7 Cassia fistula Linn. (Hindi-Amaltas; EnglishGolden Shower or Indian Laburnum), a medium sized tree belonging to the family-Caesalpiniaceae, is cultivated throughout India as an ornamental plant and is used widely for its medicinal properties. Almost every part of C. fistula are used extensively in the folklore medicine for the treatment of a variety of diseases. 8,9 The dried pod and pulp are valued for their laxative properties. The pulp is considered a safe purgative, recommended for pregnant women and children to relieve disorders of the liver and biliousness. It is a remedy for malaria and black water fever. It is also used to...

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Section: Determination Of Blood Glucosementioning

confidence: 99%

Evaluation of Antidiabetic Activity of Hydroalcoholic Extract of Cassia fistula Linn. pod in Streptozotocin-Induced Diabetic Rats

Jangir¹,

Jain²

2017

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“…An important study based on animal model has shown that oral administration of extract seeds of C. fistula such as aqueous extract to mated female rats from day 1–5 of pregnancy at the doses of 100 and 200 mg/kg body weight resulted in 57.14% and 71.43% prevention of pregnancy, respectively, and furthermore, 100% pregnancy inhibition was noted at 500 mg/kg bw. [5]…”

Section: Botanical Information Of Cassia Fistulamentioning

confidence: 99%

“…Studies based on the animal model have confirmed that C. fistula and their constituents shows a role in diseases management via modulation of biological activities. A range of studies reported the activity C. fistula as antifertility[5] and anti-microbial. [67] A study results concluded that the aqueous extract of fruit pulp of C. fistula possesses significant hepatoprotective activity.…”

Section: Introductionmentioning

confidence: 99%

Cassia fistulaLinn: Potential candidate in the health management

Rahmani¹

2015

Phcog Res

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Cassia fistula Linn is known as Golden shower has therapeutics importance in health care since ancient times. Research findings over the last two decade have confirmed the therapeutics consequence of C. fistula in the health management via modulation of biological activities due to the rich source of antioxidant. Several findings based on the animal model have confirmed the pharmacologically safety and efficacy and have opened a new window for human health management. This review reveals additional information about C. fistula in the health management via in vivo and in vitro study which will be beneficial toward diseases control.

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“…C. fistula has been reported to have antifertility, antipyretic, analgesic, anti-inflammatory, hypoglycemic effects, and antimicrobial activity. − …”

Section: Introductionmentioning

confidence: 99%

“…Animal model-based studies have shown that C. fistula and their constituents play a role in disease management via modulation of biological activities. 8 C. fistula has been reported to have antifertility, 9 antipyretic, analgesic, anti-inflammatory, hypoglycemic effects, and antimicrobial activity. 10−14 In the current study, first, we searched the literature for the mention of the chemical constituents of C. through mass spectrometry techniques.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Antileishmanial Potential ofCassia fistulaLeaf Extract

et al. 2021

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Cassia fistula has a wide array of biologically active and therapeutically important class of compounds. Leishmania donovani important drug targets, sterol 24-c methyltransferase (LdSMT), trypanothione reductase (LdTR), pteridine reductase (LdPTR1), and nucleoside hydrolase (LdNH), were modelled, and molecular docking was performed against the abundant phytochemicals of its leaf extract. Molecular docking results provided the significant prima facie evidence of the leaf extract to have antileishmanial potential. To confirm this, we performed in vitro antileishmanial and cytotoxicity assays. Methanolic extract of C. fistula leaves showed growth inhibition and proliferation of L. donovani promastigote with an IC 50 value of 43.31 ± 4.202 μg/mL. It also inhibited the growth of intra-macrophagic amastigotes with an IC 50 value of 80.76 ± 3.626 μg/mL. C. fistula extract was found cytotoxic at a very high concentration on human macrophages (CC 50 = 626 ± 39 μg/mL). Annexin V/propidium iodide (PI) staining assay suggested partial apoptosis induction in parasites by C. fistula to exert its antileishmanial activity. Here, for the first time, we have shown the antileishmanial potential of C. fistula leaves. Overall, our results could open new insight for an affordable and natural antileishmanial with high efficacy and less toxicity.

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Untitled

Cited by 31 publications

References 16 publications

Evaluation of Antidiabetic Activity of Hydroalcoholic Extract of Cassia fistula Linn. pod in Streptozotocin-Induced Diabetic Rats

Evaluation of Antidiabetic Activity of Hydroalcoholic Extract of Cassia fistula Linn. pod in Streptozotocin-Induced Diabetic Rats

Cassia fistulaLinn: Potential candidate in the health management

Assessment of the Antileishmanial Potential ofCassia fistulaLeaf Extract

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