ALA-D and ALA-D reactivated as biomarkers of lead contamination in the fish Prochilodus lineatus

Lombardi, Paula E.; Perí, Silvia I.; Guerrero, Noemí R. Verrengia

doi:10.1016/j.ecoenv.2010.06.005

Cited by 26 publications

(10 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lead has affinity for -SH groups and it is well known to inhibit ALA-D activity, performing as Pb exposure and effective biomarker to high exposure. Therefore, ALA-D has been used as a biomarker for the detection of lead-induced oxidative damage in red blood cells (RBCs), especially in occupational exposure [ 22 , 36 , 40 ]. However, few studies have evaluated the effects of metal on ALA-D activity in children [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, ALA-D have high sensitivity to -SH oxidation by pro-oxidant elements, such as toxic metals, leading to inhibition of their activity [ 36 , 38 ]. For Pb exposure, the ALA-D activity has been considered an important clinical biomarker for a long time, since Pb binds to -SH groups inhibiting this enzyme activity [ 22 , 36 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Toxic Metals and Essential Elements in Children with Learning Disabilities from a Rural Area of Southern Brazil

Nascimento

Charão

Moro

et al. 2014

IJERPH

View full text Add to dashboard Cite

Children’s exposure to metals can result in adverse effects such as cognitive function impairments. This study aimed to evaluate some toxic metals and levels of essential trace elements in blood, hair, and drinking water in children from a rural area of Southern Brazil. Cognitive ability and δ-aminolevulinate dehydratase (ALA-D) activity were evaluated. Oxidative stress was evaluated as a main mechanism of metal toxicity, through the quantification of malondialdehyde (MDA) levels. This study included 20 children from a rural area and 20 children from an urban area. Our findings demonstrated increase in blood lead (Pb) levels (BLLs). Also, increased levels of nickel (Ni) in blood and increase of aluminum (Al) levels in hair and drinking water in rural children were found. Deficiency in selenium (Se) levels was observed in rural children as well. Rural children with visual-motor immaturity presented Pb levels in hair significantly increased in relation to rural children without visual-motor immaturity (p < 0.05). Negative correlations between BLLs and ALA-D activity and positive correlations between BLLs and ALA-RE activity were observed. MDA was significantly higher in rural compared to urban children (p < 0.05). Our findings suggest that rural children were co-exposed to toxic metals, especially Al, Pb and Ni. Moreover, a slight deficiency of Se was observed. Low performance on cognitive ability tests and ALA-D inhibition can be related to metal exposure in rural children. Oxidative stress was suggested as a main toxicological mechanism involved in metal exposure.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Toxic Metals and Essential Elements in Children with Learning Disabilities from a Rural Area of Southern Brazil

Nascimento

Charão

Moro

et al. 2014

IJERPH

View full text Add to dashboard Cite

show abstract

“…The accumulation leads to biomagnifications at different tropic levels in food chains and is therefore referred to as a cumulative poison [54]. Based on our results, we can argue that the bacterial strains are sensitive tools to biomonitor lead contaminated environmental sites and can contribute to their bioremediation.…”

Section: Lead(ii) Ionmentioning

confidence: 85%

Purple non-sulfur photosynthetic bacteria monitor environmental stresses

Kis

Sipka

Asztalos

et al. 2015

Journal of Photochemistry and Photobiology B: Biology

View full text Add to dashboard Cite

a b s t r a c tHeavy metal ion pollution and oxygen deficiency are major environmental risks for microorganisms in aqueous habitat. The potential of purple non-sulfur photosynthetic bacteria for biomonitoring and bioremediation was assessed by investigating the photosynthetic capacity in heavy metal contaminated environments. Cultures of bacterial strains Rhodobacter sphaeroides, Rhodospirillum rubrum and Rubrivivax gelatinosus were treated with heavy metal ions in micromolar (Hg 2+ ), submillimolar (Cr 6+ ) and millimolar (Pb 2+ ) concentration ranges. Functional assays (flash-induced absorption changes and bacteriochlorophyll fluorescence induction) and electron micrographs were taken to specify the harmful effects of pollution and to correlate to morphological changes of the membrane. The bacterial strains and functional tests showed differentiated responses to environmental stresses, revealing that diverse mechanisms of tolerance and/or resistance are involved. The microorganisms were vulnerable to the prompt effect of Pb 2+ , showed weak tolerance to Hg 2+ and proved to be tolerant to Cr 6+ . The reaction center controlled electron transfer in Rvx. gelatinosus demonstrated the highest degree of resistance against heavy metal exposure.

show abstract

“…Waters from areas with multiple records of Ospreys, such as the Iguazú , Paraná, Uruguay, and the de la Plata rivers are known for their high levels of contamination (Cataldo et al 2001, Cid et al 2011, Colombo et al 2011. High levels of environmental pollutants, including polychlorinated biphenyls (PCBs), other organochlorines, and heavy metals have also been reported in ray-finned fish and other freshwater fish (Cataldo et al 2001, Lombardi et al 2010, Cid et al 2011, Colombo et al 2011) and fish-eating birds from central Argentina in La Florida reservoir, San Luis province (Cid et al 2007); thus, Ospreys in Argentina could also be exposed to these pollutants.…”

Section: Discussionmentioning

confidence: 99%