ALA, Fatty Fish or Marine n-3 Fatty Acids for Preventing DM?: A Systematic Review and Meta-Analysis

Muley, Arti; Muley, Prasad; Shah, Monali

doi:10.2174/1573399810666140515113137

Cited by 51 publications

(47 citation statements)

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“…These biological markers, however, reflect a shorter exposure duration relative to the one year assessment of traditional food intakes. Similar to our findings, in postmenopausal Chinese women BMD was 3.2-6.8% higher in the top quintile compared to lowest quintile of traditional sea fish intake [29] and higher frequency of intakes of fish in a meta-analysis associated with reduced risk of T2D [30]. Traditional food patterns including fish and seafood also associate with lower HbA1c [14].…”

Section: Discussionsupporting

confidence: 87%

Forearm bone density is not elevated in Inuit women with impaired fasting glucose or type 2 diabetes mellitus

Natour

Morin

Egeland

et al. 2019

International Journal of Circumpolar Health

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Bone mineral density (BMD) and fracture risk are elevated in adults with impaired fasting glucose (IFG) or type 2 diabetes mellitus (T2D). This study aimed to compare bone health among Inuit women with IFG, T2D and normoglycemia. The study included Inuit women (≥40 y) with IFG (n = 57), T2D (n = 72) or normoglycemia (n = 340) from the International Polar Year Inuit Health Survey 2007-2008 in Canada. Distal one-third forearm BMD (FaBMD) was measured using a peripheral instantaneous x-ray imager. Anthropometry, fasting plasma glucose (FPG), serum adiponectin, leptin and 25-hydroxyvitamin D (25(OH)D) were measured. Traditional food intakes were surveyed. Data were analysed using mixed model ANOVA and regression models. The median age was 53 (IFG: IQR 48, 67) y and 56 (T2D: IQR 49, 63) y. Compared to normoglycemic women, FaBMD and T-scores were significantly lower in women with T2D, but not with IFG. Frequency of marine mammal intakes (ß = 0.145; 95%CI: 0.018, 0.053, p = 0.0001) positively related to FaBMD. The odds ratio of having a T-score consistent with osteoporosis was lower among women with T2D and higher BMI, while aging increased the risk. Although T2D associates with lower BMD among Inuit women, risk of osteoporosis is tempered, possibly by maintenance of a traditional lifestyle.

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Section: Discussionsupporting

confidence: 87%

Forearm bone density is not elevated in Inuit women with impaired fasting glucose or type 2 diabetes mellitus

Natour

Morin

Egeland

et al. 2019

International Journal of Circumpolar Health

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“…Poor insulin sensitivity is associated with T2DM and metabolic syndrome [10, 11]. The results of randomized control trials (RCTs) investigating the association between n-3 PUFA and insulin sensitivity were inconsistent [12–15].…”

Section: Introductionmentioning

confidence: 99%

Fish oil supplementation and insulin sensitivity: a systematic review and meta-analysis

Geng²,

et al. 2017

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BackgroundFish oil supplementation has been shown to be associated with a lower risk of metabolic syndrome and benefit a wide range of chronic diseases, such as cardiovascular disease, type 2 diabetes and several types of cancers. However, the evidence of fish oil supplementation on glucose metabolism and insulin sensitivity is still controversial. This meta-analysis summarized the exist evidence of the relationship between fish oil supplementation and insulin sensitivity and aimed to evaluate whether fish oil supplementation could improve insulin sensitivity.MethodsWe searched the Cochrane Library, PubMed, Embase database for the relevant studies update to Dec 2016. Two researchers screened the literature independently by the selection and exclusion criteria. Studies were pooled using random effect models to estimate a pooled SMD and corresponding 95% CI. This meta-analysis was performed by Stata 13.1 software.ResultsA total of 17 studies with 672 participants were included in this meta-analysis study after screening from 498 published articles found after the initial search. In a pooled analysis, fish oil supplementation had no effects on insulin sensitivity compared with the placebo (SMD 0.17, 95%CI -0.15 to 0.48, p = 0.292). In subgroup analysis, fish oil supplementation could benefit insulin sensitivity among people who were experiencing at least one symptom of metabolic disorders (SMD 0.53, 95% CI 0.17 to 0.88, p < 0.001). Similarly, there were no significant differences between subgroups of methods of insulin sensitivity, doses of omega-3 polyunsaturated fatty acids (n-3 PUFA) of fish oil supplementation or duration of the intervention. The sensitivity analysis indicated that the results were robust.ConclusionsShort-term fish oil supplementation is associated with increasing the insulin sensitivity among those people with metabolic disorders.

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“…Several prospective cohort studies reported protective effects of fish consumption and n-3 FAs intake on the risk of T2D (Patel et al 2009;Nanri et al 2011;Villegas et al 2011), whereas some studies suggest positive (Kaushik et al 2009;Djoussé et al 2011) or no associations (van Woudenbergh et al 2009). Meta-analyses reported geographical differences in the associations between fish consumption, n-3 FAs, and the development of T2D; a protective association was observed in the populations of Asian countries, and a positive association was observed in the American population (Muley et al 2014). …”

Section: Introductionmentioning

confidence: 99%

Fish consumption is inversely associated with type 2 diabetes in Manitoba First Nations communities

Marushka

Batal

Sharp

et al. 2017

FACETS

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Consumption of fish and n-3 fatty acids (n-3 FAs) has been postulated to prevent type 2 diabetes (T2D). Objective: To explore the association between self-reported T2D and fish consumption, dietary n-3 FAs, and persistent organic pollutants (POP) intake in a regionally representative sample of First Nations (FNs) in Manitoba. Design: Data from the cross-sectional First Nations Food, Nutrition and Environment Study (FNFNES) collected from 706 members of 8 Manitoba FNs in 2010 were used. Household interviews were used to collect social and lifestyle data. The consumption of fish was estimated using a traditional food frequency questionnaire. Fish samples were analyzed for the presence of POP. Multiple logistic regression models adjusted for potential risk factors for T2D were developed. Results: A negative, dose-response relationship was found between fish intake and self-reported T2D. Fish consumptions of 2-3 portions per month and ≥1/week were inversely associated with T2D with odds ratio (OR) values of 0.51 (95% CI: 0.28-0.91) and 0.40 (95% CI: 0.19-0.82), respectively, compared with no fish intake. Similarly, intake of n-3 FAs was negatively associated with T2D (OR = 0.48 (95% CI: 0.30-0.77). Dietary POP intake was not associated with T2D. Conclusion: These findings suggest that the consumption of traditionally harvested fish may have a beneficial effect on T2D in Manitoba FNs.

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ALA, Fatty Fish or Marine n-3 Fatty Acids for Preventing DM?: A Systematic Review and Meta-Analysis

Cited by 51 publications

References 0 publications

Forearm bone density is not elevated in Inuit women with impaired fasting glucose or type 2 diabetes mellitus

Forearm bone density is not elevated in Inuit women with impaired fasting glucose or type 2 diabetes mellitus

Fish oil supplementation and insulin sensitivity: a systematic review and meta-analysis

Fish consumption is inversely associated with type 2 diabetes in Manitoba First Nations communities

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