ALA-PDT combined with oral acitretin in the treatment of refractory condyloma acuminatum in anal canal

Zhang, Long; Zeng, Qianwen; Li, Jinzhuo; Chen, Nian; Tang, Haichao; Xia, L.; Wu, Jinjin; Cheng, Qi

doi:10.1016/j.pdpdt.2022.103048

Cited by 8 publications

(5 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More and more studies have shown that 5-ALA-PDT can treat various skin diseases, such as refractory condyloma acuminatum [15] , diabetic foot ulcer infection [16] , and psoriasis [17] . Moderate and severe acne is also a kind of skin disease with multiple and severe skin lesions and easy to leave pigmentation and scars.…”

Section: Resultsmentioning

confidence: 99%

Effect of 5-Aminolevulinic Acid Photodynamic Therapy on Serum IL-6, IL-21, IL-23 and Th17/Treg Cell Balance in Moderate to Severe Acne

Li,

Chi

2024

IJPS

View full text Add to dashboard Cite

To investigate the effects of 5-aminolevulinic acid photodynamic therapy on serum interleukin-6, interleukin-21, interleukin-23 and T cells 17/regulatory T cell balance in moderate to severe acne patient. 70 patients with moderate to severe acne who visited our dermatology outpatient clinic from January 2023 to August 2023 were selected as the research object and were divided into the experiment group (n=35) and the control group (n=35); the experiment group were treated with 5-aminolevulinic acid-based photodynamic therapy, while the control group was given 1 mg/bid isotretinoin capsules. The patients of the two groups were treated for 6 w; enzyme-linked immunosorbent assay to detect the serum interleukin-6, interleukin-21 and interleukin-23 level. Flow cytometry to detect the percentage of helper T cells 17 and regulatory T cell. Statistical Package for the Social Sciences software to analyze the spearman correlation between interleukin-6, interleukin-21, and interleukin-23 level with T cells 17/regulatory T cell balance. There were no statistical difference in the comparison of general information between the experiment and control groups (p>0.05). The therapeutic effect of the experiment group was more than the control group (p<0.05). Before treatment, serum interleukin-6, interleukin-21, and interleukin-23 levels have no statistical difference (p>0.05) between the two groups. After treatment, there were no statistical difference in serum interleukin-6, interleukin-21 and interleukin-23 levels (p>0.05). Serum interleukin-6, interleukin-21 levels were positive correlation with regulatory T cell/T cells 17 balance, while interleukin-23 levels were negative correlation with regulatory T cell/T cells 17 balance. Serum interleukin-6, interleukin-21, interleukin-23 level and peripheral blood T cells 17/regulatory T cell balance were associated to the therapeutic effect of moderate and severe acne patients after treatment. 5-aminolevulinic acid-based photodynamic therapy significantly improved the therapeutic effect of moderate and severe acne, but had no effect on serum interleukin-6, interleukin-21, interleukin-23 and peripheral blood T cells 17/regulatory T cell balance.

show abstract

Section: Resultsmentioning

confidence: 99%

Effect of 5-Aminolevulinic Acid Photodynamic Therapy on Serum IL-6, IL-21, IL-23 and Th17/Treg Cell Balance in Moderate to Severe Acne

Li,

Chi

2024

IJPS

View full text Add to dashboard Cite

show abstract

“…Various methods have been used to treat anal/perianal condylomas, namely imiquimod, 5–7 cryotherapy, 18 laser therapy, 6,19 electrocautery, 6,9,19 photodynamic therapy, 20 and surgical excision 6 . Imiquimod is especially convenient because patients can apply it at home.…”

Section: Discussionmentioning

confidence: 99%

Argon Plasma Coagulation as Treatment for Anal Condylomas: A Narrative Review

Albuquerque

2024

J Low Genit Tract Dis

View full text Add to dashboard Cite

Objectives Anal condylomas are a manifestation of anal human papillomavirus infection and can be associated with precancerous lesions and squamous cell carcinomas. Several methods have been described for treatment, including argon plasma coagulation. A narrative review of the evidence published on this topic was conducted. Methods A search was conducted using PubMed, Scopus, and Web of Science databases. Results Five studies reported on anal/perianal condyloma treatment with argon plasma coagulation. In 3 of these studies, there was a comparison with other treatment methods (addition of imiquimod, electrofulguration, and electrocautery, respectively). Argon plasma coagulation settings varied between studies. This type of treatment was effective for ablation. Recurrence rates and follow-up times varied largely between studies. No major complications, such as pain, scarring, sexual dysfunction, or severe bleeding were described. Conclusion Studies indicate that argon plasma coagulation is an effective and safe therapy for anal and perianal condylomas.

show abstract

“…Photodynamic therapy (PDT), which engages a photodynamic reaction to target selective tissues, has been largely successful in the treatment of classic condyloma acuminata. When combined with oral acitretin and aminolevulinic acid (ALA), patients experienced a 94% cure rate [ 11 ]. When applied to GCA, PDT has yielded more ambiguous outcomes.…”

Section: Discussionmentioning

confidence: 99%

Radiation Therapy in the Management of Extensive Giant Condyloma Acuminata With Rectal Involvement: A Case Report

Sivapalan,

Loving,

Ramanathan

et al. 2024

Cureus

View full text Add to dashboard Cite

Giant condyloma acuminata (GCA) is a rare, locally aggressive manifestation of human papillomavirus (HPV) infection, typically affecting the anorectal area. Patients with GCA often have a poor prognosis due to the high risk of malignant transformation. In this case report, we present a 39-year-old man with HIV who developed progressive and refractory anorectal GCA. Despite initially non-cancerous pathology results, there were concerns regarding a malignant component to the mass. Multidisciplinary discussions led to the decision to pursue definitive radiation therapy. This case report and review of the literature highlight the role of radiation in the management of GCA and the importance of a multidisciplinary approach in the treatment of complex cases.

show abstract

ALA-PDT combined with oral acitretin in the treatment of refractory condyloma acuminatum in anal canal

Cited by 8 publications

References 28 publications

Effect of 5-Aminolevulinic Acid Photodynamic Therapy on Serum IL-6, IL-21, IL-23 and Th17/Treg Cell Balance in Moderate to Severe Acne

Effect of 5-Aminolevulinic Acid Photodynamic Therapy on Serum IL-6, IL-21, IL-23 and Th17/Treg Cell Balance in Moderate to Severe Acne

Argon Plasma Coagulation as Treatment for Anal Condylomas: A Narrative Review

Radiation Therapy in the Management of Extensive Giant Condyloma Acuminata With Rectal Involvement: A Case Report

Contact Info

Product

Resources

About