ALA-PDT exerts beneficial effects on chronic venous ulcers by inducing changes in inflammatory microenvironment, especially through increased TGF-beta release: A pilot clinical and translational study

Grandi, Vieri; Bacci, Stefano; Corsi, Alessandro; Sessa, Maurizio; Puliti, Elisa; Murciano, Nicoletta; Scavone, Francesca; Cappugi, Pietro; Pimpinelli, Nicola

doi:10.1016/j.pdpdt.2017.12.012

Cited by 32 publications

(56 citation statements)

References 11 publications

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“…Specifically, it promotes the epithelial‐mesenchymal transition and induces keratinocytes to migrate from the wound margins towards the centre. It also stimulates the chemotaxis of fibroblasts in the wound bed, promotes their synthesis of collagen, and induces them to differentiate into myofibroblasts . The studies included in this systematic review showed that PDT of infected wounds increased their β‐fibroblast growth factor, TGF‐β1, and VEGF levels while decreasing their IL‐6, IL‐1α, IL‐1β, IL‐2, malondialdehyde, toll‐like receptor‐4, NF‐κB, and TNF‐α.…”

Section: Discussionmentioning

confidence: 94%

“…It also stimulates the chemotaxis of fibroblasts in the wound bed, promotes their synthesis of collagen, and induces them to differentiate into myofibroblasts. 55,60 The studies included in this systematic review showed that PDT of infected wounds increased their β-fibroblast growth factor, TGF-β1, and VEGF levels while decreasing their IL-6, IL-1α, IL-1β, IL-2, malondialdehyde, toll-like receptor-4, NF-κB, and TNF-α. Thus, PDT effectively alters the inflammatory environment of infected wounds; these changes may directly or indirectly increase bacterial killing and promote wound closure.…”

Section: Discussionmentioning

confidence: 98%

“…Several studies have shown that PDT can change the immune status of the target tissue. 54,55 First, it has a significant impact on neutrophil activation: after PDT, neutrophils gather in the target lesions. This reaction is due in part to upregulated TNF-α expression after PDT.…”

Section: Discussionmentioning

confidence: 99%

“…Several human studies have shown that PDT is excellent at accelerating uninfected wound healing. 55,59 Our systematic review suggests that this effect may be due in part to the antimicrobial activity of PDT, which may prevent infections from taking hold and preventing wound closure. It also shows that PDT is effective in even heavily infected wounds.…”

Section: Discussionmentioning

confidence: 99%

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Antimicrobial photodynamic therapy in skin wound healing: A systematic review of animal studies

Sun

Ogawa

Xiao

et al. 2019

International Wound Journal

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Bacterial infection is a common wound complication that can significantly delay healing. Classical local therapies for infected wounds are expensive and are frequently ineffective. One alternative therapy is photodynamic therapy (PDT). We conducted a systematic review to clarify whether PDT is useful for bacteria‐infected wounds in animal models. PubMed and Medline were searched for articles on PDT in infected skin wounds in animals. The language was limited to English. Nineteen articles met the inclusion criteria. The overall study methodological quality was moderate, with a low‐moderate risk of bias. The animal models were mice and rats. The wounds were excisional, burn, and abrasion wounds. Wound size ranged from 6 mm in diameter to 1.5 × 1.5 cm2. Most studies inoculated the wounds with Pseudomonas aeruginosa or methicillin‐resistant Staphylococcus aureus. Eleven and 17 studies showed that the PDT of infected wounds significantly decreased wound size and bacterial counts, respectively. Six, four, and two studies examined the effect of PDT on infected wound‐cytokine levels, wound‐healing time, and body weight, respectively. Most indicated that PDT had beneficial effects on these variables. PDT accelerated bacteria‐infected wound healing in animals by promoting wound closure and killing bacteria.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Antimicrobial photodynamic therapy in skin wound healing: A systematic review of animal studies

Sun

Ogawa

Xiao

et al. 2019

International Wound Journal

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“…Secara teknis warna RGB dipresentasikan dengan tiga komponen nilai. Setiap komponen nilai dapat bernilai 0 sampai 255 [15], [16] dimana (0,0,0) dipreyeksikan sebagai warna hitam dan (255,255,255) sebagai warna putih. RGB inilah disebut dengan colour space [17] yang dapat memproyeksikan warna utama sehingga menjadi warna yang additive.…”

Section: Pendahuluanunclassified

Segmentasi luka diabetes menggunakan algoritma contour image processing

Roshandri

Utami

Prasetio

2021

JSTIE

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Positive effects of low‐dose photodynamic therapy with aminolevulinic acid or its methyl ester in skin rejuvenation and wound healing: An update

Zhang

Liu

Wang

2023

Journal of Biophotonics

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In dermatology, photodynamic therapy (PDT) is widely used in skin tumors, infections, etc., because of the killing effect triggered by toxic reactive oxygen species (ROS). However, the ROS concentration is determined by various photosensitizer concentrations and formulations, as well as various irradiation parameters. Low‐dose PDT leads to sufficiently low ROS level, which results in biological effects that are the exact opposite of the killing potency. Therefore, in recent years, low‐dose PDT has been exploited in improving aging and wound. Low‐dose ALA/MAL PDT might improve aging through promoting the proliferation of fibroblasts, blocking DNA damage, counteracting oxidative stress, inhibiting melanogenesis, and remodeling lymphatic vessels in aged skin. Promoting fibroblasts and epidermal stem cells proliferation and migration, promoting granulation tissue formation and angiogenesis and regulating the inflammatory process might be the mechanisms of low‐dose ALA/MAL PDT in wound healing. Nevertheless, the positive effects of low‐dose PDT have not been thoroughly investigated in dermatology, and high‐quality studies are still needed to fill the relevant vacancy.

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ALA-PDT exerts beneficial effects on chronic venous ulcers by inducing changes in inflammatory microenvironment, especially through increased TGF-beta release: A pilot clinical and translational study

Cited by 32 publications

References 11 publications

Antimicrobial photodynamic therapy in skin wound healing: A systematic review of animal studies

Antimicrobial photodynamic therapy in skin wound healing: A systematic review of animal studies

Segmentasi luka diabetes menggunakan algoritma contour image processing

Positive effects of low‐dose photodynamic therapy with aminolevulinic acid or its methyl ester in skin rejuvenation and wound healing: An update

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