Alanine administration does not stimulate gluconeogenesis in preterm infants

Kempen, Anne A. M. W. van; Romijn, Johannes A.; Ruiter, An F.C.; Endert, E.; Weverling, Gerrit Jan; Kok, Johnn Henry Herrera; Sauerwein, Hans P.

doi:10.1016/s0026-0495(03)00148-3

Cited by 19 publications

(10 citation statements)

References 30 publications

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“…To the best of our knowledge, there are no data about alanine supplementation in heart failure. Moreover, the few studies assessing the effects of alanine supplementation failed to indicate any beneficial effects in preterm infants or in the severely ill (29,49).…”

Section: Discussionmentioning

confidence: 99%

Aortic banding in rat as a model to investigate malnutrition associated with heart failure

Héliès-Toussaint¹,

Moinard²,

Rasmusen³

et al. 2005

American Journal of Physiology-Regulatory, Integrative and Comp

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Heart failure is a severe pathology, which has displayed a dramatic increase in the occurrence of patients with chronic heart disease in developed countries, as a result of increases in the population's average age and in survival time. This pathology is associated with severe malnutrition, which worsens the prognosis. Although the cachexia associated with chronic heart failure is a well-known complication, there is no reference animal model of malnutrition related to heart failure. This study was designed to evaluate the nutritional status of rats in a model of loss of cardiac function obtained by ascending aortic banding. Cardiac overload led to the development of cardiac hypertrophy, which decompensates to heart failure, with increased brain natriuretic peptide levels. The rats displayed hepatic dysfunction and an associated renal hypotrophy and renal failure, evidenced by the alteration in renal function markers such as citrullinemia, creatininemia, and uremia. Malnutrition has been evidenced by the alteration of protein and amino acid metabolism. A muscular atrophy with decreased protein content and increased amino acid concentrations in both plasma and muscle was observed. These rats with heart failure displayed a multiorgan failure and malnutrition, which reflected the clinical situation of human chronic heart failure.

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Section: Discussionmentioning

confidence: 99%

Aortic banding in rat as a model to investigate malnutrition associated with heart failure

Héliès-Toussaint¹,

Moinard²,

Rasmusen³

et al. 2005

American Journal of Physiology-Regulatory, Integrative and Comp

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show abstract

“…Studies measuring gluconeogenesis in nonfasted premature infants show that the availability of gluconeogenic substrates is not impaired [81].…”

Section: Gluconeogenesismentioning

confidence: 99%

Glucose metabolism in children: influence of age, fasting, and infectious diseases

et al. 2009

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“…In infants born as early as 25–26 weeks of gestation parenteral glycerol enhances gluconeogenesis [13]. On the other hand, administration of alanine did not enhance gluconeogenesis, despite a high plasma alanine level [14]. Glycerol enters the gluconeogenic pathway at the level of the triose phosphate pool whereas alanine enters at the pyruvate level (fig.…”

Section: Altered Glucose Metabolism In Preterm Infantsmentioning

confidence: 99%

Glucose Regulation in Preterm Newborn Infants

Mitanchez¹

2007

Horm Res Paediatr

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After birth, continuous transplacental transfer of glucose is interrupted. Neonates have to provide brain and vital organs with sufficient glucose. In term newborn infants, this is accomplished through well-coordinated hormonal and metabolic adaptive changes. During the first week of life, preterm infants are at high risk of abnormal glucose homeostasis. They are at risk of hypoglycemia due to limited glycogen and fat stores that should have occurred in the third trimester. Continuous glucose infusion is always required soon after birth to maintain the glucose level. However, under such conditions, many preterm infants develop hyperglycemia. Defective islet β-cell processing of proinsulin is likely related to hyperglycemia. There is also evidence that preterm infants are partially resistant to insulin. By contrast with adults, hepatic glucose production is not suppressed during parenteral glucose infusion. Exogenous insulin infusion partially reduces endogenous glucose production in preterm newborn infants. This treatment is efficient and safe when used with caution. More research is needed to understand the specificity of glucose homeostasis in preterm infants and to evaluate the long-term consequences of metabolic and nutritional support during early life.

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Alanine administration does not stimulate gluconeogenesis in preterm infants

Cited by 19 publications

References 30 publications

Aortic banding in rat as a model to investigate malnutrition associated with heart failure

Aortic banding in rat as a model to investigate malnutrition associated with heart failure

Glucose metabolism in children: influence of age, fasting, and infectious diseases

Glucose Regulation in Preterm Newborn Infants

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