2004
DOI: 10.1128/jcm.42.8.3518-3524.2004
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Alanine-Threonine Polymorphism of Helicobacter pylori RpoB Is Correlated with Differential Induction of Interleukin-8 in MKN45 Cells

Abstract: Geographical differences in the genetic diversity of Helicobacter pylori isolates were examined by analyzing rpoB sequences. An extremely high level of allelic diversity among H. pylori strains was found. The rpoB sequences of Asian and non-Asian (North and South American, European, and South African) strains were found to differ. An amino acid polymorphism (alanine and threonine RpoB types) was found at the 497th residue by deduced amino acid analysis. RpoB with a threonine residue (RpoB Thr ) was uniquely pr… Show more

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Cited by 13 publications
(9 citation statements)
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“…These observations demonstrate that gastric cells expressing a1,4-GlcNAc-capped Oglycans protect themselves against Hp infection. Our results showed no expression of terminal a1,4-GlcNAc with the gastric carcinoma cell lines studied ( Table 2), demonstrating that the cell lines used in the present and in previous studies (Lee et al 2004;Keates et al 2005) are suitable models for Hp coculture/adhesion experiments.…”
Section: Discussionmentioning
confidence: 59%
“…These observations demonstrate that gastric cells expressing a1,4-GlcNAc-capped Oglycans protect themselves against Hp infection. Our results showed no expression of terminal a1,4-GlcNAc with the gastric carcinoma cell lines studied ( Table 2), demonstrating that the cell lines used in the present and in previous studies (Lee et al 2004;Keates et al 2005) are suitable models for Hp coculture/adhesion experiments.…”
Section: Discussionmentioning
confidence: 59%
“…Japan, USA) [11]. In this study, samples were collected by the same team and RNA extraction and pathology diagnosis were performed by the same individuals, allowing for a comparison between areas that differed greatly in relation to gastric cancer incidence and H. pylori cagA genotype.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, 67.6% of East Asian H. pylori strains possessed RpoB Thr , compared to only 2.9% of western strains, and RpoB Thr induced significantly more IL-8 secretion from MKN45 cells than RpoB Ala . 55 This protein may therefore increase inflammation in infected subjects in East Asia and increase the risk of development of more severe gastroduodenal diseases.…”
Section: Blood Group Antigen Binding Adhesion a (Baba)mentioning
confidence: 99%