Alantolactone: A sesquiterpene lactone with diverse pharmacological effects

Liu, Xin; Bian, Lijuan; Duan, Xiaoqin; Zhuang, Xiaoxi; Sui, Yujie; Yang, Longfei

doi:10.1111/cbdd.13972

Cited by 29 publications

(25 citation statements)

References 119 publications

(250 reference statements)

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“…Sesquiterpene lactones, a member of the terpene family, have important roles as pharmaceutical agents due to their many biological and therapeutic potentials such as antioxidant, antinociceptive, anti-cancer, and antiinflammatory [21][22][23] . Farnesene (FNS) is a sesquiterpene lactone present in various plants and foods, with a wide range of biological effects.…”

Section: Introductionmentioning

confidence: 99%

Otoprotective effects of farnesene against oxidative damage induced by paclitaxel

Dinçer

Atalay

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2022

Cukurova Medical Journal

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Amaç: Bu çalışmanın amacı, güçlü serbest radikal süpürücü ve antioksidan özelliklere sahip farnesenin paklitaksel kaynaklı ototoksisite üzerindeki etkilerini biyokimyasal ve fonksiyonel yönden araştırmaktır. Gereç ve Yöntem: On sekiz erkek Wistar albino sıçan, altı sıçandan oluşan üç gruba rastgele ayrıldı. Araştırma boyunca kontrol grubuna paklitaksel veya farnesen verilmedi. Paklitaksel grubuna, 5mg/kg paklitaksel intraperitoneal olarak dört kez (1., 7., 14. ve 21. günlerde) verildi. Farnesen + paklitaksel grubuna, önce 5 mg/kg paklitaksel, 30 dakika sonra 50 mg/kg farnesen intraperitoneal olarak 4 kez (1., 7., 14. ve 21. günlerde) verildi. 0. ve 21. günlerde tüm sıçanların otoakustik emisyon ölçümü yapıldı. Daha sonra hayvanlar sakrifiye edildi ve biyokimyasal testler için kokleaları çıkarıldı. Bulgular: Paklitaksel, önemli ölçüde malondialdehit seviyelerini yükselterek ve glutatyon seviyelerini düşürerek kokleada oksidatif strese neden oldu. Ayrıca paklitaksel grubunun distorsiyon ürünü otoakustik emisyon değerleri diğer gruplara göre anlamlı derecede düşüktü. Farnesen+paklitaksel grubunda ise paklitakselin çeşitli biyokimyasal ve fonksiyonel parametrelerde oluşturduğu hasarda iyileşmeler gözlendi. Sonuç: Çalışma sonuçları doğal bir antioksidan olan farnesen’in sıçanlarda paklitaksel kaynaklı işitme kaybını azalttığını, farnesen ve paklitaksel kombinasyonunun gelecekte klinik kullanım için paklitaksel kaynaklı ototoksisiteden koruyabileceğini göstermektedir.

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Section: Introductionmentioning

confidence: 99%

Otoprotective effects of farnesene against oxidative damage induced by paclitaxel

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Atalay

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2022

Cukurova Medical Journal

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“…It exerts widely pharmacological roles including anti-inflammatory, antimicrobial, neuroprotective activities, and anticancer properties. 10 In recent years, alantolactone has been reported to exert anticancer effects via inducing apoptosis against various types of cancer lines such as breast cancer, liver cancer, cervical cancer, and gastric cancer cells. [11][12][13][14] Main mechanisms of action of these cancers are as follows: Alantolactone inhibits migration in human breast cancer cells via the p38 MAPK, NF-κB signalling pathways.…”

Section: Introductionmentioning

confidence: 99%

Alantolactone inhibits oesophageal adenocarcinoma cells through nuclear factor erythroid 2‐related factor 2‐mediated reactive oxygen species increment

Chen

Zhang

Huang

et al. 2022

Basic Clin Pharma Tox

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Background Oesophageal adenocarcinoma (EAC) is a highly lethal cancer associated with a rapidly rising incidence and a poor prognosis. Alantolactone, a sesquiterpene lactone isolated from inula helenium, has anti‐inflammatory, antimicrobial, neuroprotective activities, and anticancer properties. Objective In the present study, the anticancer effects of alantolactone on the human EAC cells were investigated in vitro and in vivo. Methods and findings After treated with alantolactone, the cell viability of KYAE‐1, KYAE‐2, OE19, and OE33 cells reduced significantly compared with that of the control cells. Alantolactone induced apoptosis of the EAC cell lines by inhibiting the protein expression levels of nuclear factor erythroid2‐related factor 2 (Nrf2). Furthermore, the apoptosis‐inducing effect of alantolactone was enhanced by Nrf2 knockdown while reduced by overexpression of Nrf2. Antioxidant α‐tocopherol and glutathione can protect EAC cell lines against alantolactone. A xenograft nude mice model showed that alantolactone can inhibit EAC growth in vivo. Conclusions Alantolactone inhibits oesophageal adenocarcinoma cells through Nrf2‐mediated reactive oxygen species (ROS) increment. Alantolactone maybe a potential therapeutical candidate for treating EAC.

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“…Apart from antitumoral effects, it has traditionally shown anti-inflammatory, antimicrobial, and neuroprotective activities. 150 5.2. Other Therapeutic Purposes.…”

Section: Cancer Treatmentmentioning

confidence: 99%

“…On the other hand, alantoalactone is present in the extracts of Inula helenium L. and Inula racemos herbs and in other plants of the family Asteraceae. Apart from antitumoral effects, it has traditionally shown anti-inflammatory, antimicrobial, and neuroprotective activities …”

Section: Successful Cases Of Blending Tcm and Active Ingredients From...mentioning

confidence: 99%

The Integration of Nanomedicine with Traditional Chinese Medicine: Drug Delivery of Natural Products and Other Opportunities

et al. 2022

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The integration of progressive technologies such as nanomedicine with the use of natural products from traditional medicine (TM) provides a unique opportunity for the longed-for harmonization between traditional and modern medicine. Although several actions have been initiated decades ago, a disparity of reasons including some misunderstandings between each other limits the possibilities of a truly complementation. Herein, we analyze some common challenges between nanomedicine and traditional Chinese medicine (TCM). These challenges, if solved in a consensual way, can give a boost to such harmonization. Nanomedicine is a recently born technology, while TCM has been used by the Chinese people for thousands of years. However, for these disciplines, the regulation and standardization of many of the protocols, especially related to the toxicity and safety, regulatory aspects, and manufacturing procedures, are under discussion. Besides, both TCM and nanomedicine still need to achieve a wider social acceptance. Herein, we first briefly discuss the strengths and weaknesses of TCM. This analysis serves to focus afterward on the aspects where TCM and nanomedicine can mutually help to bridge the existing gaps between TCM and Western modern medicine. As discussed, many of these challenges can be applied to TM in general. Finally, recent successful cases in scientific literature that merge TCM and nanomedicine are reviewed as examples of the benefits of this harmonization.

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Alantolactone: A sesquiterpene lactone with diverse pharmacological effects

Cited by 29 publications

References 119 publications

Otoprotective effects of farnesene against oxidative damage induced by paclitaxel

Otoprotective effects of farnesene against oxidative damage induced by paclitaxel

Alantolactone inhibits oesophageal adenocarcinoma cells through nuclear factor erythroid 2‐related factor 2‐mediated reactive oxygen species increment

The Integration of Nanomedicine with Traditional Chinese Medicine: Drug Delivery of Natural Products and Other Opportunities

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