Alarm pheromone and kairomone detection via bitter taste receptors in the mouse Grueneberg ganglion

Moine, Fabian; Brechbühl, Julien; Tosato, Monique Nenniger; Beaumann, Manon; Broillet, Marie-Christine

doi:10.1186/s12915-017-0479-y

Cited by 24 publications

(29 citation statements)

References 69 publications

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“…In Gli3 Xt/Xt mice, we found Sox10 ϩ Schwann cells around the trigeminal nerve ( Fig. 5) and around the fibers of the sensory Grueneberg ganglion (data not shown) (Liu et al, 2009;Matsuo et al, 2012;Moine et al, 2018). We also found Sox10 ϩ OECs surrounding the FCM proximal to the OBs.…”

Section: Discussionmentioning

confidence: 65%

Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration

et al. 2019

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During mammalian development, gonadotropin-releasing-hormone-1 neurons (GnRH-1ns) migrate from the developing vomeronasal organ (VNO) into the brain asserting control of pubertal onset and fertility. Recent data suggest that correct development of the olfactory ensheathing cells (OEC) is imperative for normal GnRH-1 neuronal migration. However, the full ensemble of molecular pathways that regulate OEC development remains to be fully deciphered. Loss-of-function of the transcription factor Gli3 is known to disrupt olfactory development, however, if Gli3 plays a role in GnRH-1 neuronal development is unclear. By analyzing Gli3 extra-toe mutants (Gli3 Xt/Xt), we found that Gli3 loss-of-function compromises the onset of achaete-scute family bHLH transcription factor 1 (Ascl-1) ϩ vomeronasal progenitors and the formation of OEC in the nasal mucosa. Surprisingly, GnRH-1 neurogenesis was intact in Gli3 Xt/Xt mice but they displayed significant defects in GnRH-1 neuronal migration. In contrast, Ascl-1 null mutants showed reduced neurogenesis for both vomeronasal and GnRH-1ns but less severe defects in OEC development. These observations suggest that Gli3 is critical for OEC development in the nasal mucosa and subsequent GnRH-1 neuronal migration. However, the nonoverlapping phenotypes between Ascl-1 and Gli3 mutants indicate that Ascl-1, while crucial for GnRH-1 neurogenesis, is not required for normal OEC development. Because Kallmann syndrome (KS) is characterized by abnormal GnRH-1ns migration, we examined whole-exome sequencing data from KS subjects. We identified and validated a GLI3 loss-of-function variant in a KS individual. These findings provide new insights into GnRH-1 and OECs development and demonstrate that human GLI3 mutations contribute to KS etiology.

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Section: Discussionmentioning

confidence: 65%

Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration

et al. 2019

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“…Our understanding of the interplay between the pathways processing GG-induced fear-like responses and those encoding food-odorant information remains to be completed. GG neurons use multi-signaling pathways, principally linked to bitter taste signaling 28 and GCG cascades 18 to detect a large repertoire of chemical danger cues 28,29 . Interestingly, in GC-D neurons, a similar encoding strategy occurs 14 making it also sensitive to fatty acids, steroid hormones as well as to some GG-related cues such as pyrazines.…”

Section: Discussionmentioning

confidence: 99%

The Grueneberg ganglion controls odor-driven food choices in mice under threat

et al. 2020

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The ability to efficiently search for food is fundamental for animal survival. Olfactory messages are used to find food while being aware of the impending risk of predation. How these different olfactory clues are combined to optimize decision-making concerning food selection remains elusive. Here, we find that chemical danger cues drive the food selection in mice via the activation of a specific olfactory subsystem, the Grueneberg ganglion (GG). We show that a functional GG is required to decipher the threatening quality of an unfamiliar food. We also find that the increase in corticosterone, which is GG-dependent, enhances safe food preference acquired during social transmission. Moreover, we demonstrate that memory retrieval for food preference can be extinguished by activation of the GG circuitry. Our findings reveal a key function played by the GG in controlling contextual food responses and illustrate how mammalian organisms integrate environmental chemical stress to optimize decision-making.

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“…4). For that, we first used Ga gustucin (GUST) as a marker of sensory cells in the tongue 32 , to identify taste buds in close contact with the oral cavity (Fig. 4a).…”

Section: Sars-cov-2 Entry Cells In the Moed Are Of Non-neuronal And Mmentioning

confidence: 99%

Age-dependent appearance of SARS-CoV-2 entry cells in mouse chemosensory systems reflects COVID-19 anosmia and ageusia symptoms

Brechbühl

Wood

Bouteiller

et al. 2021

Preprint

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COVID-19 pandemic has given rise to a collective scientific effort to study its viral causing agent SARS-CoV-2. Research is focusing in particular on its infection mechanisms and on the associated-disease symptoms. Interestingly, this environmental pathogen directly affects the human chemosensory systems leading to anosmia and ageusia. Evidence for the presence of the cellular entry sites of the virus, the ACE2 and the TMPRSS2 proteins, has been reported in non-chemosensory cells in the nose and mouth of the rodents, missing a direct correlation between the symptoms reported in patients and the observed direct viral infection in human sensory cells. Here, mapping the gene and protein expression of ACE2 and TMPRSS2 in the mouse olfactory and gustatory cells, we precisely identified the virus target cells to be of basal and sensory origin and we revealed their age-dependent appearance. Our results not only clarify human viral-induced sensory symptoms but also propose new investigative perspectives based on ACE2-humanized mouse models.

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Alarm pheromone and kairomone detection via bitter taste receptors in the mouse Grueneberg ganglion

Cited by 24 publications

References 69 publications

Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration

Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration

The Grueneberg ganglion controls odor-driven food choices in mice under threat

Age-dependent appearance of SARS-CoV-2 entry cells in mouse chemosensory systems reflects COVID-19 anosmia and ageusia symptoms

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