ALAT, AP, ASAT, GGT, OCT Activities and Urea and Total Bilirubin Concentrations in Plasma of Normal and Ketotic Dairy Cows

Kauppinen, Kauko

doi:10.1111/j.1439-0442.1984.tb01316.x

Cited by 30 publications

(24 citation statements)

References 21 publications

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“…Steen et al [23] reported that the GGT level increased significantly in cows with fatty liver compared with normal cows. Some of the animals with ketosis also had elevated GGT levels, as seen in another study [14]. The plasma TG level is also affected by dietary fat.…”

Section: Discussionsupporting

confidence: 52%

Slow Recovery of Blood Glucose in the Insulin Tolerance Test during the Prepartum Transition Period Negatively Impacts the Nutritional Status and Reproductive Performance Postpartum of Dairy Cows

Lee

Kida

Miura

et al. 2012

The Journal of Veterinary Medical Science

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AbSTRACT. In peripartum dairy cows, insulin resistance (IR) increases to adjust the direction of energy to lactation after calving. To investigate the effect of prepartum IR on postpartum reproductive performance, the insulin tolerance test (ITT) was applied to 15 cows at 3 weeks (Pre21) and 10 days (Pre10) before the predicted calving date. blood glucose area under the curve (AUC glu ) within 120 min after administration of 0.05 IU/kg-BW insulin was calculated. The occurrence of first ovulation, days to first artificial insemination (AI) and first AI conception rate were recorded. Nutritional status postpartum was evaluated by blood chemical analysis. Based on AUC glu changes from Pre21 to Pre10, cows were classified into either the AUC-up group (AUC glu increase, n=5) or the AUC-down group (AUC glu decrease, n=10). There was no difference in the decrease in blood glucose at 30 min after insulin injection between groups, although glucose recovery from 30 to 60 min during the ITT was slow at Pre10 in the AUC-up group. The AUC-up group had a higher number of days to first AI and high glucose, total protein, globulin, γ-glutamyltransferase, triacylglycerol levels and a low albumin-globulin ratio at the 14th day postpartum. The present study infers that prepartum slow glucose recovery rather than insulin sensitivity might increase the potential for subclinical health problems postpartum and thus suppress reproductive performance. During the prepartum transition period, glucose dynamics in the ITT can be considered as a new indicator for the postpartum metabolic status and reproductive performance of dairy cows.

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Section: Discussionsupporting

confidence: 52%

Slow Recovery of Blood Glucose in the Insulin Tolerance Test during the Prepartum Transition Period Negatively Impacts the Nutritional Status and Reproductive Performance Postpartum of Dairy Cows

Lee

Kida

Miura

et al. 2012

The Journal of Veterinary Medical Science

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“…Fatty liver syndrome in lactating cows may reduce the appetite (Cebra et al, 1997), and ketosis at early lactation may increase AST enzyme activity (Steen, 2001). This may be used as a bio-indicator for possible liver damage (Kauppinen, 1984;Meyer & Harvey, 1988). Contrary to AST activity, ruminants do not have high ALT activity.…”

Section: Discussionmentioning

confidence: 99%

“…The decrease in AST activity may be related to silymarin supplementation. As indicated, an increase in serum AST activity may be used for sub-clinic diagnosis of possible liver damage (Kauppinen, 1984;Meyer & Harvey, 1988). Therefore, different silymarin levels may be experimented with for various periods to elucidate these effects.…”

Section: Discussionmentioning

confidence: 99%

Effects of silymarin (<i>Silybum marianum</i>) supplementation on milk and blood parameters of dairy cattle

Ülger¹,

Onmaz²,

Ayaşan³

2017

SA J. An. Sci.

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The present study was conducted to investigate the effect of dietary silymarin on milk yield, milk fat, and certain blood parameters of dairy cattle. Silymarin is a naturally accepted hepatoprotectant that is used in the treatment of liver diseases in human beings, and has been tested in dairy cows during peripartum. Animals are subject to subclinical fatty liver. In the first part of the study, the silymarin (20 g/head/day) was supplemented to dairy cattle rations in the last 21 days (peripartum) of pregnancy. In the second part of study, silymarin was added to the rations of Holstein dairy cows for three weeks postpartum. A total of 40 Holstein dairy cows at 2 nd lactation with 550-600 kg live weight and average body condition score of 3.5 were used. Dairy cows were randomly separated into two treatment groups (20 cows in each). The first group was control (no addition) and the second group was treatment (silymarin supplemented) group. Treatments significantly increased milk yield, but decreased milk protein. Postpartum bodyweight loss was significantly less in the silymarin group than in the control group. Differences in postprandial plasma triglyceride (TRG) and total cholesterol (TC) levels were found to be significant. Plasma alanine aminotransferase (ALT) and total protein (TP) values of the groups were also significantly different. As a result, it was observed that silymarin supplementation of the ration did not have side effects, and peak milk yields could be achieved earlier with silymarin treatment. Application of silymarin is believed to be useful. It was also observed that silymarin treatments speeded up the metabolic adaptation process of the dairy cows at the beginning of lactation. It was suggested that silymarin should be used in transition periods of dairy cattle.

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“…Hyperbilirubinemia (total and direct) was observed in infected animals; this condition was attributed to the presence of LSDV in the blood, which may have damaged hepatocytes surrounding the bile duct, and may also have been induced by intrahepatic cholestasis and biliary disease (Stockham and Scott 2008). LSDV infection significantly increased serum AST activity, a phenomenon that reflects hepatocyte damage, even if such damage is subclinical (Kauppinen 1984;Meyer and Harvey 1998). In addition, AST is present in cardiac and skeletal muscle cells; therefore, AST elevation in our study may have been related to injury or inflammation of cardiac muscle due to the presence of LSDV in the heart (Stockham and Scott 2008;Zilva et al 1988).…”

Section: Discussionmentioning

confidence: 99%

Hematological, biochemical and oxidative stress studies of lumpy skin disease virus infection in cattle

El-Mandrawy

Alam

2018

Journal of Applied Animal Research

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Lumpy skin disease (LSD) is an important disease of cattle. This study was conducted to determine alterations in hematological, biochemical and oxidative stress markers in cattle that have been naturally infected with LSD virus (LSDV). Blood samples and skin nodular lesions were collected from clinically infected, recovered and healthy animals. Quantitative real-time PCR was used to screen for Capripoxvirus DNA in samples from clinically infected animals. Hematological, biochemical and oxidative stress markers were measured. LSDV nuclic acids were detected in the collected samples using PCR. Hematological results revealed erythrocytosis, thrombocytopenia and leukopenia in infected cattle. Biochemical analyses showed that total protein and globulin levels were significantly elevated, while albumin and glucose were significantly reduced in these cattle. Aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatine phosphokinase (CPK), and creatinine levels were markedly elevated. Moreover, serum levels of reduced glutathione (GSH) were markedly lowered, whereas lipid peroxidation (MDA) and inflammatory cytokines (IL-4 and TNF-α) were elevated. Recovered cattle exhibited significant amelioration of the alterations resulting from LSDV infection. The results of this study suggest that LSDV infection induces changes in hematological and biochemical parameters and stimulates oxidative stress; these findings may be helpful for choosing a good strategy for rapidly detecting and diagnosing LSDV infection. ARTICLE HISTORY

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ALAT, AP, ASAT, GGT, OCT Activities and Urea and Total Bilirubin Concentrations in Plasma of Normal and Ketotic Dairy Cows

Cited by 30 publications

References 21 publications

Slow Recovery of Blood Glucose in the Insulin Tolerance Test during the Prepartum Transition Period Negatively Impacts the Nutritional Status and Reproductive Performance Postpartum of Dairy Cows

Slow Recovery of Blood Glucose in the Insulin Tolerance Test during the Prepartum Transition Period Negatively Impacts the Nutritional Status and Reproductive Performance Postpartum of Dairy Cows

Effects of silymarin (<i>Silybum marianum</i>) supplementation on milk and blood parameters of dairy cattle

Hematological, biochemical and oxidative stress studies of lumpy skin disease virus infection in cattle

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