Albendazole in Hydatid Disease: Results in 22 Patients

Yasawy, Mohamed I.; Mohamed, Abdelrahman E.; Al-Karawi, Mohamed A.

doi:10.5144/0256-4947.1992.152

Cited by 8 publications

(2 citation statements)

References 17 publications

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“…Various degrees of enhanced activity ranging from synergy/addition to partial enhancement were found. Although this is the first in vitro demonstration of enhanced activity of combination therapy using T. solium larval cysts in vitro, enhanced activity has been described in the cestodes T. crassiceps (16) and E. granulosus and E. multilocularis in vitro (12,(25)(26)(27)(28)(29)(30), as well as in imperfect human case series against E. granulosus in vivo (8,33). Kaur et al found enhanced but nonsignificant decrease in estimated time to clearance of single enhancing lesions using combined therapy in NCC compared to single therapy in India T. crassiceps has been used in vitro and in vivo to evaluate effectiveness of cysticidal drugs.…”

Section: Discussionmentioning

confidence: 99%

Sensitive In Vitro System To Assess Morphological and Biochemical Effects of Praziquantel and Albendazole on Taenia solium Cysts

Mahanty

Paredes

Marzal

et al. 2011

Antimicrob Agents Chemother

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Neurocysticercosis resulting from Taenia solium infections is a major cause of adult-acquired seizures worldwide. Disease is caused by larval cysts, and treatment consists of the anthelmintic drugs albendazole or praziquantel. There are no standard methods to assess drug activity to T. solium cysts in vitro. Morphological, functional, and biochemical changes that might reflect damaging (inhibiting, cytotoxic) drug effects were analyzed after exposure of cysts to albendazole sulfoxide (ABZ-SO), the major active metabolite of the drug in vivo, praziquantel (PZQ), or combinations of both. PZQ exposure led to a decrease in cyst size and inhibition of evagination, whereas ABZ-SO exposure resulted in minimal changes. Alkaline phosphatase (AP) is normally secreted by cysts, and both drugs inhibited AP secretion at concentrations of 5 and 50 ng/ml for PZQ and ABZ-SO, respectively. Some combinations of both drugs resulted in additive and/or synergistic activities. Parasite-specific antigen, detected in the cerebrospinal fluid and blood of infected patients, is also normally secreted by T. solium cysts. Antigen secretion was similarly inhibited by ABZ-SO and PZQ and a combination of both drugs, suggesting that inhibition of secretion is a common downstream consequence of the activities of both drugs. These studies establish quantitative methods to measure in vitro anthelmintic activity and suggest combination therapy with ABZ-SO and PZQ may have clinical benefit. Neurocysticercosis (NCC), the most common cause of adult acquired seizures worldwide, results from infection of the brain by the cystic larval stage of Taenia solium. The adult tapeworm resides in the human intestines. It consists of a head with a scolex, which is an attachment organ, a neck, and increasingly maturing segments containing infectious ova. These are excreted as segments in the feces and, when ingested by freeroaming pigs, hatch and are carried to the brain, muscles, and other organs, where they develop into viable cysts in about 2 to 3 months. After ingestion and exposure to bile and other factors in the gastrointestinal tract milieu, the cysts evaginate and develop into tapeworms. Humans develop NCC after accidental ingestion of infectious ova sometimes originating from their own tapeworm or one residing in a family member or coinhabitant.The clinical manifestations of NCC are due to growth, degeneration, and inflammation associated with the host response to the cyst. Treatment consists of the anthelmintic agents albendazole or praziquantel (PZQ) (4, 5, 15), as well as corticosteroids or other anti-inflammatory agents (4,14), that are commonly used to control treatment-induced inflammation. However, cure rates are relatively low with currently available regimens, and more effective agents are needed.T. solium larval cysts (metacestodes) can only be obtained from infected pigs. Studies using T. solium cysts are difficult because many infected pigs are required, harvesting cysts individually is laborious and time-consuming, and culturing and maintain...

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Section: Discussionmentioning

confidence: 99%

Sensitive In Vitro System To Assess Morphological and Biochemical Effects of Praziquantel and Albendazole on Taenia solium Cysts

Mahanty

Paredes

Marzal

et al. 2011

Antimicrob Agents Chemother

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“…L'Albendazole est la molécule la plus efficace, utilisée en cures de 3 à 4 semaines séparées par des intervalles de 7 à 14 jours pendant 9 à 12 mois. Il serait efficace dans 10 à 15 % des cas [18,19]. Ce traitement reste malheureusement peu utilisé dans notre contexte à cause du coût assez élevé de la molécule ainsi qu'au manque d'observance des patients, souvent démunis et analphabètes.…”

Section: Discussionunclassified

L’hydatidose péritonéale. A propos de 27 cas

Louzi

Jgounni

Narjis

et al. 2011

J Afr Hepato Gastroenterol

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Effects of isoprinosine onEchinococcus multilocularis andE. granulosus metacestodes

1995

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An in vivo study of the effect of Isoprinosine on Echinococcus multilocularis and E. granulosus metacestodes (Cestoda) was performed. Short- and long-term treatments with different doses were tested in experimental hosts: jirds for E. multilocularis and mice for E. granulosus. Modifications in the weight of animals as well as macroscopical and ultrastructural aspects were registered for each animal group. The results obtained showed a considerable ultrastructural alteration in E. multilocularis metacestodes after short-term treatment with the highest dose, and the tissue transplants were negative. In E. granulosus cysts the ultrastructural damage was also very important and its severity increased as the dose was raised. For the two parasites, the macroscopical aspect and weight of the lesions were profoundly changed.

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Albendazole in Hydatid Disease: Results in 22 Patients

Cited by 8 publications

References 17 publications

Sensitive In Vitro System To Assess Morphological and Biochemical Effects of Praziquantel and Albendazole on Taenia solium Cysts

Sensitive In Vitro System To Assess Morphological and Biochemical Effects of Praziquantel and Albendazole on Taenia solium Cysts

L’hydatidose péritonéale. A propos de 27 cas

Effects of isoprinosine onEchinococcus multilocularis andE. granulosus metacestodes

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