Albendazole treatment and serological follow-up in hydatid disease of bone

Primary hydatid cyst of the root of the thigh: a case report and review of the literature

“…These data confirm the importance of a meticulous removal of all the lesions including the microscopic ones, combined with many cycles of aggressive neoadjuvant and adjuvant chemotherapy [22].…”

“…The correct and most effective treatment is a wide surgical excision of the tissues involved. A cycle of antihelminthic neoadjuvant chemotherapy with Albendazole or Mebendazole [6,21,22] must always precede surgery when there are active cysts, as in the case we describe, or even when the surrounding tissues are significantly involved, in order to decrease the lesion size and make surgical excision easier. An adjuvant chemotherapy treatment can help reducing the risk of recurrence [3-6, 21, 22].…”

Spinal Hydatidosis

“…Adjuvant antihelmintic chemotherapy is essential to control the disease locally, avoid systemic spread, and prevent recurrence. [13][14][15][16][17][18] In our case, preoperative chemotherapy was not possible because the disease was silent for a long time; and in the majority of cases, the first symptom was spinal cord compression that was treated by early surgical decompression. We think that preoperative antibiotic chemoprophylaxis and postoperative antibiotic therapy are important because surgery is extensive and the appearance of postoperative surgical wound infection is frequent.…”

Intradural extramedullary primary hydatid cyst of the spine: a case report and review of literature

“…Reports also indicate that irrigating the wound with hypertonic saline or a diluted betadine solution after cyst removal helps osmotically destroy and disrupt the parasites, although this remains unproven [4]. Adjuvant antihelmintic chemotherapy is essential to control the disease locally, to avoid systemic spread, and to prevent recurrence [54, 55]. The poor prognosis may be related to the localization (intradurally or extradurally) of the cyst and weak penetration of antihelminting drug, albendozole, and metabolites into the intradural space by a passive diffusion transport mechanism [51].…”