Albizia anthelmintica: HPLC-MS/MS profiling and in vivo anti-inflammatory, pain killing and antipyretic activities of its leaf extract

Sobeh, Mansour; Rezq, Samar; Sabry, Omar M.; Abdelfattah, Mohamed A.O.; Raey, Mohamed A. El; El‐Kashak, Walaa A.; El-Shazly, Assem M.; Mahmoud, Mona F.

doi:10.1016/j.biopha.2019.108882

Cited by 33 publications

(45 citation statements)

References 30 publications

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“…The simplest gallotaninnin, glucogallic acid (7), with molecular formula of C 13 H 16 O 10 and precursor [M-H] − , ion at m / z 331 was found in almost all, besides water extracts. The prominent fragment ions at m / z 169, 125 corresponded to the gallic acid fragmentation, while fragments at m / z 313, 271, 241 and 211 originated from cross-ring fragmentation of a glucose molecule and were consistent with literature data [ 46 , 48 ]. Similar product ions were observed in the MS/MS spectra of compound 13 ( m / z 483) identified in two polar (methanolic and aqueous) extracts.…”

Section: Resultssupporting

confidence: 90%

“…Quercetin (48) was identified in all studies extracts in 30.914 min, on the basis of a typical for this structure fragment ions mentioned above. For compounds 37, 38 and 41 the typical for hexosides (both for glucosides and galactosides) and glucoronides neutral loss of 162 and 176 Da from precursor ion was observed in MS/MS spectra, respectively.…”

Section: Other Polyphenolsmentioning

confidence: 80%

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LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium pyrenaicum Burm. f.: A Good Gift from the Natural Treasure

Świątek

Sieniawska

Sinan

et al. 2021

IJMS

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This study focused on the biological evaluation and chemical characterization of Geranium pyrenaicum Burm. f. Different solvent extracts (hexane, ethyl acetate, methanol, and water extracts) were prepared. The phytochemical profile, antioxidant, and enzyme inhibitory activity were investigated. Cytotoxicity was assessed using VERO, FaDu, HeLa and RKO cells. The antiviral activity was carried out against HSV-1 (Herpes simplex virus 1) propagated in VERO cell line. The aqueous extract, possessing high phenolic content (170.50 mg gallic acid equivalent/g extract), showed the highest reducing capacity (613.27 and 364.10 mg Trolox equivalent/g extract, for cupric reducing antioxidant capacity and ferric reducing antioxidant power, respectively), radical scavenging potential (469.82 mg Trolox equivalent/g extract, against 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)), metal chelating ability (52.39 mg ethylenediaminetetraacetic acid equivalent/g extract) and total antioxidant capacity (3.15 mmol Trolox equivalent/g extract). Liquid chromatography-electrospray ionization-quadrupole time-of-flight-mass spectrometry (LC-ESI-QTOF-MS/MS) alloved to tentatively identify a total of 56 compounds in the extracts, including ellagitannins, gallic acid and galloyl derivatives amongst others. The ethyl acetate extracts substantially depressed cholinesterase enzymes (4.49 and 12.26 mg galantamine equivalent/g extract against AChE and BChE, respectively) and α-amylase enzyme (1.04 mmol acarbose equivalent/g extract). On the other hand, the methanolic extract inhibited tyrosinase (121.42 mg kojic acid equivalent/g extract) and α-glucosidase (2.39 mmol acarbose equivalent/g extract) activities. The highest selectivity towards all cancer cell lines (SI 4.5–10.8) was observed with aqueous extract with the FaDu cells being the most sensitive (CC50 40.22 µg/mL). It can be concluded that the presence of certain bioactive antiviral molecules may be related to the high anti HSV-1 activity of the methanolic extract. This work has generated vital scientific data on this medicinal plant, which is a prospective candidate for the creation of innovative phyto-pharmaceuticals.

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Section: Resultssupporting

confidence: 90%

Section: Other Polyphenolsmentioning

confidence: 80%

LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium pyrenaicum Burm. f.: A Good Gift from the Natural Treasure

Świątek

Sieniawska

Sinan

et al. 2021

IJMS

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“…In consistent with a previous report, the ethanolic extract of A. myriophylla wood inhibited the release of nitric oxide production with IC 50 value of 13.8 µg/ml [17]. In another study, methanolic extract from leaves of A. anthelmintica revealed antiinflammatory activity by decreasing the production of inflammatory mediators, PGE2 and leukotrienes, via inhibition of COX-1, COX-2, and 5-LOX, with IC 50 values of 4.11, 0.054, and 1.74 µg/ml, respectively [19]. Our findings suggest that the moderate in vitro anti-inflammatory activity of the ethanolic extracts may act mostly through the NO production pathway.…”

Section: Resultsmentioning

confidence: 96%

Antioxidant, anti-inflammatory, and anti-Staphylococcal activities of Albizia lucidior (Steud.) I. C. Nielsen wood extracts

Phuaklee¹,

Dechayont²,

Chunthorng-Orn³

et al. 2021

ScienceAsia

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“…Most of the phenolic acid derivatives are glycosides, their first stage of fragmentation is the cleavage of the glycosidic bond to produce the m/z of the phenolic acid and the respective neutral mass loss of sugar molecules, and then neutral mass losses of methyl, hydroxyl or carboxylic groups helped to identify the specific phenolic acid. Coumaric acid (2) [18], p-hydroxybenzoic hexoside (3) [19], caffeic acid derivative (4) and ferulic acid derivative (38) [20], trihydroxyursolic acid derivative (7) [24], methoxycinnamic acid hexoside (8) and methoxy benzoic acid hexoside (29) [19], caffeic acid hexoside (9) [25], sinapic acid-3-O-glucoside (25) and its isomer (36) [38], ethyl gallate (28) and its isomer (34) [39], protocatechualdehyde…”

Section: Phenolic Acid Derivativesmentioning

confidence: 99%

UPLC-ESI-MS/MS Profile of The Ethyl Acetate Fraction of Aerial Parts of Bougainvillea 'Scarlett O'Hara' Cultivated in Egypt

et al. 2020

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The ethyl acetate fraction of Bougainvillea 'Scarlett O'Hara' cultivated in Egypt did not receive enough attention in phytochemical and biological studies. This inspired the authors to investigate the phytochemicals of this fraction for the first time using UPLC-ESI-MS/MS in negative and positive ionization modes to understand the distribution of the major secondary metabolites. The analysis revealed the tentative identification of fifty-seven compounds. The detected metabolites belonged to numerous chemical classes including seven organic acids, fourteen phenolic compounds, one betacyanin, seven anthocyanins, ten flavonoids, three saponins, six tannins, four cyclic tetrapyrolic derivatives and five miscellaneous. The LC-ESI-MS methodology in negative ionization mode was the most appropriate to detect the group of saponins (22.17%), flavonoids (14.27%), free organic (12.35%) and phenolic acid derivatives (14%). It can be seen that the highest ionization rate produced for cyclic tetrapyrolic derivatives (56.41%), anthocyanins (18.8%) and tannins (3.2%) in the positive mode chromatogram.

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Albizia anthelmintica: HPLC-MS/MS profiling and in vivo anti-inflammatory, pain killing and antipyretic activities of its leaf extract

Cited by 33 publications

References 30 publications

LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium pyrenaicum Burm. f.: A Good Gift from the Natural Treasure

LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium pyrenaicum Burm. f.: A Good Gift from the Natural Treasure

Antioxidant, anti-inflammatory, and anti-Staphylococcal activities of Albizia lucidior (Steud.) I. C. Nielsen wood extracts

UPLC-ESI-MS/MS Profile of The Ethyl Acetate Fraction of Aerial Parts of Bougainvillea 'Scarlett O'Hara' Cultivated in Egypt

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