Albucidin: a novel bleaching herbicide from Streptomyces albus subsp. chlorinus NRRL B-24108

Hahn, Donald R.; Graupner, Paul R.; Chapin, E. L.; Gray, John A.; Heim, Dale R.; Gilbert, J.; Gerwick, Ben C.

doi:10.1038/ja.2009.11

Cited by 35 publications

(32 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All spectra were recorded with the standard 1 H pulse program using 128 scans. The structure of albucidin was confirmed by comparison of the recorded 1 H NMR data ( Figure S1) with published data [10].…”

Section: Albucidin Isolation and 1 H-nmr Spectroscopymentioning

confidence: 59%

See 1 more Smart Citation

Identification and Heterologous Expression of the Albucidin Gene Cluster from the Marine Strain Streptomyces Albus Subsp. Chlorinus NRRL B-24108

et al. 2020

View full text Add to dashboard Cite

Herbicides with new modes of action and safer toxicological and environmental profiles are needed to manage the evolution of weeds that are resistant to commercial herbicides. The unparalleled structural diversity of natural products makes these compounds a promising source for new herbicides. In 2009, a novel nucleoside phytotoxin, albucidin, with broad activity against grass and broadleaf weeds was isolated from a strain of Streptomyces albus subsp. chlorinus NRRL B-24108. Here, we report the identification and heterologous expression of the previously uncharacterized albucidin gene cluster. Through a series of gene inactivation experiments, a minimal set of albucidin biosynthetic genes was determined. Based on gene annotation and sequence homology, a model for albucidin biosynthesis was suggested. The presented results enable the construction of producer strains for a sustainable supply of albucidin for biological activity studies.

show abstract

Section: Albucidin Isolation and 1 H-nmr Spectroscopymentioning

confidence: 59%

“…A novel bleaching herbicide, albucidin, from the strain Streptomyces albus subsp. chlorinus NRRL B-24108 was discovered in 2009 [10]. In this paper, we present the identification, heterologous expression, and engineering of the albucidin gene cluster.…”

Section: Introductionmentioning

confidence: 99%

Identification and Heterologous Expression of the Albucidin Gene Cluster from the Marine Strain Streptomyces Albus Subsp. Chlorinus NRRL B-24108

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The fractions are re‐assessed for unique structural features, subsequently purified, and tested for bioactivity . At CAS, the focus on a bioactivity‐based tactic has proven fruitful, albeit lengthy, in identifying agrochemically relevant NPs of interest . The specific workflow and screening cascade utilized currently is illustrated in Fig.…”

Section: Strategies To Identify Natural Productsmentioning

confidence: 99%

“…46 At CAS, the focus on a bioactivity-based tactic has proven fruitful, albeit lengthy, in identifying agrochemically relevant NPs of interest. 21,31,40,42,47 The specific workflow and screening cascade utilized currently is illustrated in Fig. 6.…”

Section: Strategies To Identify Natural Productsmentioning

confidence: 99%

Natural products: a strategic lead generation approach in crop protection discovery

Lorsbach

Sparks

Cicchillo

et al. 2019

Pest Management Science

Self Cite

View full text Add to dashboard Cite

With the anticipated population growth in the coming decades, the changing regulatory environment, and the continued emergence of resistance to commercial pesticides, there is a constant need to discover new lead chemistries with novel modes of action. We have established a portfolio of approaches to accelerate lead generation. One of these approaches capitalizes on the rich bioactivity of natural products (NPs), highlighted by the numerous examples of NP‐based crop protection compounds. Within Corteva Agriscience and the affiliated preceding companies, NPs have been a fruitful approach, for nearly three decades, to identifying and bringing to the market crop protection products inspired by or originating from NPs, . Included in these NP‐based crop protection products are the spinosyns family of insecticides, and those from more recent areas of NP‐based fungicidal chemistry, as highlighted in this perspective. © 2019 Society of Chemical Industry

show abstract

“…Subsequently, albucidin was isolated from Streptomyces albus subsp. chlorinus NRRL B‐24 108 for its phytotoxic activity using a bioassay‐guided fractionation 58. The compound is a very potent nucleoside toxin, with lethality rates at less than 100 g ha −1 in some plant species, that induces chlorosis and bleaching.…”

Section: Natural Products With Target Sites Not Currently Affected Bymentioning

confidence: 99%

Rationale for a natural products approach to herbicide discovery

Dayan

Owens

Duke

2012

Pest Management Science

180

150

View full text Add to dashboard Cite

Weeds continue to evolve resistance to all the known modes of herbicidal action, but no herbicide with a new target site has been commercialized in nearly 20 years. The so-called 'new chemistries' are simply molecules belonging to new chemical classes that have the same mechanisms of action as older herbicides (e.g. the protoporphyrinogen-oxidase-inhibiting pyrimidinedione saflufenacil or the very-long-chain fatty acid elongase targeting sulfonylisoxazoline herbicide pyroxasulfone). Therefore, the number of tools to manage weeds, and in particular those that can control herbicide-resistant weeds, is diminishing rapidly. There is an imminent need for truly innovative classes of herbicides that explore chemical spaces and interact with target sites not previously exploited by older active ingredients. This review proposes a rationale for a natural-products-centered approach to herbicide discovery that capitalizes on the structural diversity and ingenuity afforded by these biologically active compounds. The natural process of extended-throughput screening (high number of compounds tested on many potential target sites over long periods of times) that has shaped the evolution of natural products tends to generate molecules tailored to interact with specific target sites. As this review shows, there is generally little overlap between the mode of action of natural and synthetic phytotoxins, and more emphasis should be placed on applying methods that have proved beneficial to the pharmaceutical industry to solve problems in the agrochemical industry.

show abstract

Albucidin: a novel bleaching herbicide from Streptomyces albus subsp. chlorinus NRRL B-24108

Cited by 35 publications

References 11 publications

Identification and Heterologous Expression of the Albucidin Gene Cluster from the Marine Strain Streptomyces Albus Subsp. Chlorinus NRRL B-24108

Identification and Heterologous Expression of the Albucidin Gene Cluster from the Marine Strain Streptomyces Albus Subsp. Chlorinus NRRL B-24108

Natural products: a strategic lead generation approach in crop protection discovery

Rationale for a natural products approach to herbicide discovery

Contact Info

Product

Resources

About