Albumin adsorption on CoCrMo alloy surfaces

Yan, Yu; Yang, Hang; Su, Yanjing; Qiao, Lijie

doi:10.1038/srep18403

Cited by 43 publications

(37 citation statements)

References 34 publications

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“…However, the present results showed the opposite, with greater amounts of Fn or Alb adsorbed onto more negatively charged Ti. Yan et al investigated Alb adsorption onto CoCrMo alloy at different pH values [ 26 ]. At pH 10.0, Alb was negatively charged and the alloy surface was positively charged.…”

Section: Discussionmentioning

confidence: 99%

Protein Adsorption to Titanium and Zirconia Using a Quartz Crystal Microbalance Method

Kusakawa

Yoshida

Hayakawa

2017

BioMed Research International

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Protein adsorption onto titanium (Ti) or zirconia (ZrO2) was evaluated using a 27 MHz quartz crystal microbalance (QCM). As proteins, fibronectin (Fn), a cell adhesive protein, and albumin (Alb), a cell adhesion-inhibiting protein, were evaluated. The Ti and ZrO2 sensors for QCM were characterized by atomic force microscopy and electron probe microanalysis observation, measurement of contact angle against water, and surface roughness. The amounts of Fn and Alb adsorbed onto the Ti and ZrO2 sensors and apparent reaction rate were obtained using QCM measurements. Ti sensor showed greater adsorption of Fn and Alb than the ZrO2 sensor. In addition, amount of Fn adsorbed onto the Ti or ZrO2 sensors was higher than that of Alb. The surface roughness and hydrophilicity of Ti or ZrO2 may influence the adsorption of Fn or Alb. With regard to the adsorption rate, Alb adsorbed more rapidly than Fn onto Ti. Comparing Ti and ZrO2, Alb adsorption rate to Ti was faster than that to ZrO2. Fn adsorption will be effective for cell activities, but Alb adsorption will not. QCM method could simulate in vivo Fn and Alb adsorption to Ti or ZrO2.

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Section: Discussionmentioning

confidence: 99%

Protein Adsorption to Titanium and Zirconia Using a Quartz Crystal Microbalance Method

Kusakawa

Yoshida

Hayakawa

2017

BioMed Research International

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“…In fact, the metallic surface had a neutral charge, while the HA molecules were negatively charged. On the other hand, the metallic surface was certainly covered by proteins, because proteins from biological fluids are known to adsorb onto biomaterial surfaces almost instantaneously [26,32,33]. The additional presence of H 2 O 2 likely caused an oxidation of the metal surface through the adsorbed protein layer with growth of an unstable (porous) oxide film.…”

Section: Electrochemical Measurementsmentioning

confidence: 99%

The effect of hyaluronic acid on the corrosion of an orthopedic CoCrMo-alloy in simulated inflammatory conditions

et al. 2019

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During joint inflammation, various reactive oxygen species (ROS) are present in the surrounding tissue and joint fluid. In the laboratory, hydrogen peroxide (H 2 O 2) is typically used to simulate inflammatory conditions, and media containing proteins and hyaluronic acid (HA) are employed to simulate joint synovial fluid. Electrochemical interactions between H 2 O 2 and HA in the presence of a CoCrMo surface are expected, since HA molecules contain redox-active moieties. We hypothesized that any redox reactions of these moieties with ROS will mitigate the oxidizing effect of H 2 O 2 on the CoCrMo surface, limiting the corrosion rate of the metal. Non-destructive electrochemical measurements (open circuit potential, linear polarization resistance and electrochemical impedance spectroscopy) were used to investigate the corrosion response of CoCrMo in synovial model fluid containing physiologically relevant concentrations of albumin proteins and hyaluronic acid, with and without H 2 O 2. Two different molarities of H 2 O 2 , 3 mM and 30 mM, were tested. While both molarities are within physiological limits, 3mM is well within the range HA could mitigate, whereas 30 mM is not. Contrary to our hypothesis, HA did not alleviate corrosion in 3 mM H 2 O 2 and even caused a corrosion increase in the case of 30 mM H 2 O 2. The decrease in corrosion resistance of the alloy may be attributed to the complexation of degenerated HA molecular chains with chromium ions released from the metallic surface, which are necessary to build a protective oxide film. This finding has clinical implications, suggesting that HA accelerates corrosion of CoCrMo implants in the presence of strong inflammation.

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“…AgF 2 ) [19] -and without the need to apply an electric field in the FET setup in the process. Guidance from theoretical studies [20] proves to be important for achieving the desired level of doping in nanoelectronics devices formed using modern single-layer deposition and epitaxial growth technologies. [9,21] The new method may help to bypass limitations connected with charge injection using electrostatic and electrochemical [22] or ionic-liquid solventbased [23] doping to thin layers.…”

mentioning

confidence: 99%

Separation‐Controlled Redox Reactions

2021

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In the era of molecular devices and nanotechnology, precise control over electron-transfer processes is strongly desired. However, redox reactions are usually characterized by reaction equilibrium constants strongly departing from unity. This leads to strong favoring of either reactants or products and does not permit subtle control of transferred charge (doping).Here we propose, based on theoretical studies for periodic systems, how charge transfer between reactants could be finely manipulated in the epitaxially grown system composed of extremely strong oxidizer, reducing agent, and an inert separator-the key factor of control.Electron transfer reactions, together with acid-base ones, constitute the most important types of elemental processes in chemistry. One unique feature of redox reactions is that their equilibrium constants strongly depart from unity. For example, for a model one-electron reaction where the standard redox potentials, E 0 , for the two involved redox pairs differ by a mere 0.1 V, the reaction equilibrium constant, K [Eq. (1)] K eq ¼ expðDE 0 F=RTÞ ð1Þ

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Albumin adsorption on CoCrMo alloy surfaces

Cited by 43 publications

References 34 publications

Protein Adsorption to Titanium and Zirconia Using a Quartz Crystal Microbalance Method

Protein Adsorption to Titanium and Zirconia Using a Quartz Crystal Microbalance Method

The effect of hyaluronic acid on the corrosion of an orthopedic CoCrMo-alloy in simulated inflammatory conditions

Separation‐Controlled Redox Reactions

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