Albumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcoma

Gu, Wenguang; Zhang, Tao; Gao, Jinghong; Wang, Yi; Li, Dejian; Zhao, Ziwen; Jiang, Bo; Dong, Zhiwei; Liu, Hui

doi:10.1080/10717544.2019.1662513

Cited by 32 publications

(21 citation statements)

References 42 publications

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“…The application of iridium oxide (IrO 2 ) has recently drawn attention due to its high biocompatibility and photothermal conversion efficiency [ 32 ]. Studies have discovered that IrO 2 has catalase (CAT)-like activity that enables it to catalyze H 2 O 2 in the TME to generate endogenous O 2 , thereby enhancing the efficiency of PDT [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of iridium-based nanocomposite with catalase activity for cancer phototherapy

Jiang

Luo

et al. 2021

J Nanobiotechnol

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The combination of photothermal therapy (PTT) and photodynamic therapy (PDT) has attracted attention due to its enhanced tumor therapy effect. This study proposes a novel nanoenzyme-based theranostic nanoplatform, IrO2@MSN@PDA-BSA(Ce6), for the combined PTT and PDT of tumors. IrO2 was prepared by a simple hydrolysis method and coated with a thin layer of mesoporous silica (MSN) to facilitate the physical adsorption of Chlorin e6 (Ce6). The PDA coating and IrO2 NPs of the nanoplatform demonstrated an improved photothermal conversion efficiency of 29.8% under NIR irradiation. Further, the Ce6 loading imparts materials with the ability to produce reactive oxygen species (ROS) under 660 nm NIR laser irradiation. It was also proved that the IrO2 NPs could catalyze the hydrogen peroxide (H2O2) in the tumor microenvironment (TME) to generate endogenous oxygen (O2), thereby enhancing the efficiency of PDT. The in vitro and in vivo experiments indicated that the nanocomposite was highly biocompatible and could produce a satisfactory tumor therapeutic effect. Thus, the findings of the present study demonstrate the viability of using theranostic nanoenzymes for translational medicine.

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Section: Introductionmentioning

confidence: 99%

Synthesis of iridium-based nanocomposite with catalase activity for cancer phototherapy

Jiang

Luo

et al. 2021

J Nanobiotechnol

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“…Gu et al . 82 reported a bovine serum albumin-bioinspired iridium oxide nanosystem for chemophotothermal therapy of osteosarcoma. This nanosystem displayed both NIR light and pH-responsive DOX release profiles in vitro , which enhanced the therapeutic anticancer effect.…”

Section: Discussionmentioning

confidence: 99%

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Wan¹,

Zhang²,

Lv³

et al. 2020

Theranostics

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Recently, the rapid development of biomaterials has induced great interest in the precisely targeted treatment of bone-related diseases, including bone cancers, infections, and inflammation. Realizing noninvasive therapeutic effects, as well as improving bone tissue regeneration, is essential for the success of bone‑related disease therapies. In recent years, researchers have focused on the development of stimuli-responsive strategies to treat bone-related diseases and to realize bone regeneration. Among the various external stimuli for targeted therapy, near infrared (NIR) light has attracted considerable interests due to its high tissue penetration capacity, minimal damage toward normal tissues, and easy remote control properties. The main objective of this systematic review was to reveal the current applications of NIR light-assisted phototherapy for bone-related disease treatment and bone tissue regeneration. Database collection was completed by June 1, 2020, and a total of 81 relevant studies were finally included. We outlined the various therapeutic applications of photothermal, photodynamic and photobiomodulation effects under NIR light irradiation for bone‑related disease treatment and bone regeneration, based on the retrieved literatures. In addition, the advantages and promising applications of NIR light-responsive drug delivery systems for spatiotemporal-controlled therapy were summarized. These findings have revealed that NIR light-assisted phototherapy plays an important role in bone-related disease treatment and bone tissue regeneration, with significant promise for further biomedical and clinical applications.

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“…In this review three studies were identified which utilized osteosarcoma cell xenograft models to assess the PTT performance of a number of candidate formulations in vivo (Table 10). In these investigations bioactive glass scaffolds functionalized by the CuFeSe 2 nanocrystals, [ 125 ] doxorubicin‐loaded bovine serum albumin–iridium oxide NMs [ 126 ] and black phosphorus reinforced 3D‐printed scaffold [ 127 ] all exhibited complete abolition of the tumors with very little adverse side effects. The experimental detail of all relevant studies relating to bone cancer are summarized in Table 10.…”

Section: Nanomedicines Designed For Targeting and Treatment Of Cancersmentioning

confidence: 99%

A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges

Kermanizadeh

Jacobsen

Murphy

et al. 2020

Advanced Therapeutics

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The design and utilization of nanomedicines offers great potential for treating various diseases including cancers. Current challenges with traditional cancer treatment strategies include but are not limited to lack of specific targeting, overt systemic toxicity and low efficacy. The use of nanomaterials show particular promise as candidates for cancer treatment due to their high surface to volume ratio and tuneable size, shape, and surface chemistry, which in combination, allow for improved tumor targeting and enhanced therapeutic efficacy. The scrutinization of the literature demonstrates the potential of nanosized carrier systems over traditional approaches (at the molecular level) for specific targeting of the tumors. Despite the great promise showing in preclinical studies, the number of nanomedicines reaching clinical testing is still very low. This review attempts to address this issue by using a weight of evidence approach to the different strategies for use of nanomedicines in combating cancer, as well as highlighting a number of areas that the field of nanomedicines is clearly lagging behind in, as compared to conventional drug discovery and development. It is hoped that the recommendations in this review will allow for better translation of nanomedicines reaching clinical trials.

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Albumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcoma

Cited by 32 publications

References 42 publications

Synthesis of iridium-based nanocomposite with catalase activity for cancer phototherapy

Synthesis of iridium-based nanocomposite with catalase activity for cancer phototherapy

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges

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