Albumin-Bound Paclitaxel: The Benefit of This New Formulation in the Treatment of Various Cancers

Abstract

Paclitaxel and docetaxel are established as the standards of care, either as monotherapy or in combination with other cytotoxic agents in metastasic breast cancer. In order to improve the efficiency of solvent-based paclitaxel and to overcome its drawbacks in terms of safety, a solvent-free formulation has been developed. This work is a review of the albumin-bound paclitaxel data relative to its pharmacodynamic and pharmacokinetic profiles, its therapeutic efficiency and its safety of use. The activity of albumin-bound paclitaxel in phase II and III trials indicates its significant clinical efficiency in the treatment of metastatic breast cancer. In lung and pancreatic cancer and in melanoma, the use of albumin-bound paclitaxel leads to interesting results which require further investigations. Preclinical and clinical studies have shown that albumin-bound paclitaxel is associated with a better tolerance compared to standard paclitaxel.

Management of Hypersensitivity to Platinum- and Taxane-Based Chemotherapy: cepo Review and Clinical Recommendations

“…No hypersensitivity reactions were reported in several phase i, ii, and iii studies that used this agent 28,[62][63][64] , and administration of nab-paclitaxel was well tolerated in 5 patients who had previously experienced hypersensitivity reactions to paclitaxel 65 . However, one phase iii study indicated that nab-paclitaxel can cause hypersensitivity reactions 28 .…”

“…Substitution of Therapy A new formulation of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) avoids the use of Kolliphor as a vehicle, and thus premedication is not required 61,62 . No hypersensitivity reactions were reported in several phase i, ii, and iii studies that used this agent 28,[62][63][64] , and administration of nab-paclitaxel was well tolerated in 5 patients who had previously experienced hypersensitivity reactions to paclitaxel 65 .…”

Molecular Buckets: Cyclodextrins for Oral Cancer Therapy

“…Recently, this strategy of combination between cyclodextrins and bioadhesive nanoparticles has demonstrated effectiveness in improving significantly the oral bioavailability of paclitaxel [102]. This anticancer drug is widely used in clinic for the treatment of several carcinomas including breast [103], advanced ovarian [104], non small cell lung [105] and colon [106]. By the oral route, it shows a very low bioavailability, which is caused by several factors.…”

Applications of nanotechnology for melanoma treatment, diagnosis, and theranostics

“…Clinical trials have shown that Abraxane was better tolerated and more effective against melanoma than was free PTX. 44,45 However, a recent report showed that poly(gamma-L-glutamylglutamine)-PTX was more effective in reducing the growth of xenografted B16 melanoma cells than was Abraxane and had less side effects.…”