Albumin-globulin ratio and mortality in patients on peritoneal dialysis: a retrospective study

Peng, Fenfen; Sun, Lingzhi; Chen, Ting; Zhu, Yan; Zhou, Weidong; Li, Peilin; Chen, Yihua; Zhuang, Yiyi; Huang, Q.; Long, Haibo

doi:10.1186/s12882-020-1707-1

Cited by 14 publications

(11 citation statements)

References 41 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Globulin is the major constituent of non-albumin serum protein and is mainly composed of immunoglobulin, which can carry sex hormones and fatty acids, and is involved in immunologic and inflammatory processes [ 23 , 24 ]. Therefore, the globulin level can serve as a marker of a chronic inflammatory response, and higher globulin levels indicate a more severe inflammation.…”

Section: Discussionmentioning

confidence: 99%

Association of Albumin and Globulin with Mortality Risk in Incident Peritoneal Dialysis Patients

et al. 2022

View full text Add to dashboard Cite

Background: Nutrition and inflammation have been implicated in predicting mortality in patients on peritoneal dialysis (PD). Serum albumin and globulin can be regarded for the nutritional and inflammatory status. However, there is lack of data to evaluate the synergistic effect of albumin and globulin on mortality prediction. Methods: In 554 patients initiating PD from January 2001 to July 2016, we divided them into four groups by the combination of two categories of low vs. high albumin and low vs. high globulin. The median values for albumin and globulin were chosen to classify them into low or high groups. Their associations with all-cause and cardiovascular (CV) mortality were examined in Cox regression models adjusted for confounding clinical and laboratory data. Results: Patients, 52.91 ± 15.2 years old and 47.8% men, had a median (interquartile range) value of 3.3 (2.9–3.8) g/dL for albumin and 2.8 (2.5–3.2) g/dL for globulin, respectively. Patients with low albumin and high globulin had the highest all-cause mortality and CV mortality, with adjusted hazard ratios of 3.87 (95% CI 1.83–8.20, p < 0.001) and 5.65 (95% CI 2.23–14.34, p < 0.001), respectively, compared with those with a high albumin and low globulin having the lowest mortality rate. Sensitivity analyses further confirmed this relationship. Conclusions: A patient profile of either low albumin or high globulin is linked to a higher risk for mortality, particularly for a profile of both low albumin and high globulin compared with one without either of them. Further studies are needed to explore the mechanisms underlying this phenomenon and how to improve clinical outcomes in those high-risk patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of Albumin and Globulin with Mortality Risk in Incident Peritoneal Dialysis Patients

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In chronic kidney disease, AGR was suggested a simple and inexpensive measurement for detecting the risk of mortality ( 20 ). AGR has the potential to predict all-cause and cardiovascular mortality in patients on peritoneal dialysis ( 21 ). However, the effect of AGR on the clinical characteristic and prognosis in PLA patients remains unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Several recent studies have found that serum albumin/globulin ratio (AGR) can predict the prognosis of various diseases, including cancers, chronic kidney disease, heart failure, and peritoneal dialysis (17)(18)(19)(20)(21). As a serious infectious disease of the liver, PLA was associated with the decreased albumin and increased globulin, however, the clinical significance of AGR in PLA patients remains largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Clinical Significance of Serum Albumin/Globulin Ratio in Patients With Pyogenic Liver Abscess

et al. 2021

View full text Add to dashboard Cite

Pyogenic liver abscess (PLA) remains a significant challenge for modern clinicians. Serum albumin/globulin ratio (AGR) can reflect the progress of many diseases. However, the clinical significance of AGR in PLA has not been evaluated. The aim of this study was to explore the effect of AGR on the clinical characteristic and prognosis in PLA patients. This retrospective study included 392 PLA patients who admitted to the First Affiliated Hospital of Xi'an Jiaotong University from January, 2007 to December, 2016. The medical records on admission were collected. Compared with the healthy controls and the patients with extraperitoneal infection or non-infectious liver disease, PLA patients had lower levels of AGR. The mean level of AGR in PLA patients was 1.02 ± 0.25. There were 179 (45.4%) patients with AGR > 1.02 and 213 (54.6%) patients with AGR ≤ 1.02. The baseline data and treatment plans of PLA patients with high or low AGR were comparative. However, PLA patients with a low AGR had higher body temperature, leukocytes and neutrophils, lower hemoglobin, poorer liver and coagulation function, larger abscess diameter, higher positive rate of pus culture and proportion of Escherichia coli, and were more susceptible to multiple bacteria. Moreover, PLA patients with a low AGR had more complications, including systemic inflammatory response syndrome (SIRS), peritoneal effusion and pleural effusion. And it also needs longer time for temperature normalization and hospital stay. In conclusion, PLA patients have lower AGR and lower AGR is associated with worse clinical manifestations, more complications and poorer prognosis. Thus, monitoring of AGR is of great clinical significance for evaluating the progress of PLA patients.

show abstract

“…The baseline data of the patients included were collected during the stay in the RICU. The AGR was calculated by the following formula: AGR = serum albumin/(serum protein − serum albumin) [ 8 ].…”

Section: Methodsmentioning

confidence: 99%

Albumin–Globulin Ratio Is an Independent Determinant of 28-Day Mortality in Patients with Critical Illness

et al. 2021

View full text Add to dashboard Cite

Background. Critical illness in the intensive care unit (ICU) has been a global health priority. Systemic nutritional status has turned out to be related to the prognosis of critically ill patients. The albumin-globulin ratio (AGR) has been reported to be a novel prognostic factor of many diseases. This study is aimed at investigating whether the AGR could predict the mortality risk in critically ill patients. Methods. We enrolled 582 adult patients admitted to the respiratory intensive care unit (RICU). We collected the clinical and laboratory data. X-tile software was used to determine the optimal cut-off values for the AGR. Patients were divided into three groups according to the AGR (low AGR group with AGR < 0.8 , medium AGR group with AGR ranging from 0.8 to 1.1, and high AGR group with AGR > 1.1 ). Kaplan-Meier analysis was used for survival analysis. A Cox proportional hazard model was applied to the univariate and multivariate analyses for the potential predictors associated with survival. Results. Our present study showed that the AGR was related to the 28-day survival of critically ill patients in the RICU. The rate of pneumonia in the low AGR group was significantly higher than that in the other groups. Patients with a lower AGR present an increased risk of 28-day mortality compared to patients with a higher AGR. Cox regression analysis showed that the AGR might be an independent predictor of prognosis to 28-day survival in critically ill patients in the RICU. Medium and high AGR values remained independently associated with better 28-day survival than low AGR values (HR: 0.484 (0.263-0.892) ( p = 0.02 ); HR: 0.332 (0.166-0.665) ( p = 0.002 )). Conclusion. The AGR might be an independent predictor of prognosis in critically ill patients.

show abstract

Albumin-globulin ratio and mortality in patients on peritoneal dialysis: a retrospective study

Cited by 14 publications

References 41 publications

Association of Albumin and Globulin with Mortality Risk in Incident Peritoneal Dialysis Patients

Association of Albumin and Globulin with Mortality Risk in Incident Peritoneal Dialysis Patients

Clinical Significance of Serum Albumin/Globulin Ratio in Patients With Pyogenic Liver Abscess

Albumin–Globulin Ratio Is an Independent Determinant of 28-Day Mortality in Patients with Critical Illness

Contact Info

Product

Resources

About