Albumin-glutaraldehyde glue for repair of superficial lung defect: an in vitro experiment

Bures, Maximilian; Höffler, Hans‐Klaus; Friedel, Godehard; Kyriss, Thomas; Boedeker, Enole; Zardo, Patrick; Zhang, Ruoyu

doi:10.1186/s13019-016-0443-x

Cited by 12 publications

(9 citation statements)

References 19 publications

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“…369 Similar to GRFG glues, the aldehyde groups of glutaraldehyde can react with the amines of albumin and those present in the tissue to form a tight mechanical seal, independently of the coagulation system. 370 The two components, provided in liquid form, are combined and mixed through a dual syringe system for application to tissues. This adhesive is available on the market under the name of BioGlue.…”

Section: Protein Based Adhesivesmentioning

confidence: 99%

“…The first documentation of albumin-based adhesive was in 1993, where albumin was used with glutaraldehyde . Similar to GRFG glues, the aldehyde groups of glutaraldehyde can react with the amines of albumin and those present in the tissue to form a tight mechanical seal, independently of the coagulation system . The two components, provided in liquid form, are combined and mixed through a dual syringe system for application to tissues.…”

Section: Representative Examples Of Adhesivesmentioning

confidence: 99%

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Polymeric Tissue Adhesives

2021

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Polymeric tissue adhesives provide versatile materials for wound management and are widely used in a variety of medical settings ranging from minor to life-threatening tissue injuries. Compared to the traditional methods of wound closure (i.e., suturing and stapling), they are relatively easy to use, enable rapid application, and introduce minimal tissue damage. Furthermore, they can act as hemostats to control bleeding and provide a tissue-healing environment at the wound site. Despite their numerous current applications, tissue adhesives still face several limitations and unresolved challenges (e.g., weak adhesion strength and poor mechanical properties) that limit their use, leaving ample room for future improvements. Successful development of next-generation adhesives will likely require a holistic understanding of the chemical and physical properties of the tissue-adhesive interface, fundamental mechanisms of tissue adhesion, and requirements for specific clinical applications. In this review, we discuss a set of rational guidelines for design of adhesives, recent progress in the field along with examples of commercially available adhesives and those under development, tissue-specific considerations, and finally potential functions for future adhesives. Advances in tissue adhesives will open new avenues for wound care and potentially provide potent therapeutics for various medical applications.

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Section: Protein Based Adhesivesmentioning

confidence: 99%

Section: Representative Examples Of Adhesivesmentioning

confidence: 99%

Polymeric Tissue Adhesives

2021

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“…b,c) Reproduced under the terms of the CC‐BY Creative Commons Attribution 4.0 International license ( https://creativecommons.org/licenses/by/4.0/). [ 223 ] Copyright 2016, The Authors, published by Springer Nature. d) Reproduced with permission.…”

Section: Crosslinking Chemistrymentioning

confidence: 99%

Covalently Crosslinked Hydrogels via Step‐Growth Reactions: Crosslinking Chemistries, Polymers, and Clinical Impact

2021

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Hydrogels are an important class of biomaterials with the unique property of high‐water content in a crosslinked polymer network. In particular, chemically crosslinked hydrogels have made a great clinical impact in past years because of their desirable mechanical properties and tunability of structural and chemical properties. Various polymers and step‐growth crosslinking chemistries are harnessed for fabricating such covalently crosslinked hydrogels for translational research. However, selecting appropriate crosslinking chemistries and polymers for the intended clinical application is time‐consuming and challenging. It requires the integration of polymer chemistry knowledge with thoughtful crosslinking reaction design. This task becomes even more challenging when other factors such as the biological mechanisms of the pathology, practical administration routes, and regulatory requirements add additional constraints. In this review, key features of crosslinking chemistries and polymers commonly used for preparing translatable hydrogels are outlined and their performance in biological systems is summarized. The examples of effective polymer/crosslinking chemistry combinations that have yielded clinically approved hydrogel products are specifically highlighted. These hydrogel design parameters in the context of the regulatory process and clinical translation barriers, providing a guideline for the rational selection of polymer/crosslinking chemistry combinations to construct hydrogels with high translational potential are further considered.

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“…These tissues have previously displayed adverse reactions to BioGlue. 17,23,43 One limitation of this study was that a single time point was evaluated; therefore, dynamic progression of the inflammatory response, and its dominant features (e.g. eosinophil infiltration), could not be assessed.…”

Section: Discussionmentioning

confidence: 99%

Tissue reactions to polyethylene glycol and glutaraldehyde-based surgical sealants in a rabbit aorta model

et al. 2020

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Surgical sealants help achieve rapid haemostasis when applied as an adjunct to sutures in vascular surgery, but their use can lead to various side effects. This study compared the local inflammatory reaction to commercially available BioGlue and Coseal sealants in a rabbit aorta suture hole model. Twenty male New Zealand white rabbits were randomised to testing with either BioGlue or Coseal. Two weeks after sealant application to suture holes, sections of the aorta at the puncture site, and surrounding tissue, were processed for histopathological analysis. Inflammation was graded from 0 to 3 according to tissue alteration and presence of inflammatory cells. Material stiffness was measured in vitro using compression testing. From examination of the inflammatory response to the sealants, a less severe histopathological assessment score was assigned to the Coseal compared to the BioGlue group (mean AE SD: 1.56 AE 0.53 vs 2.67 AE 0.50; p ¼ 0.002). While both materials triggered a typical foreign body reaction characterised by granulomatous inflammation, BioGlue additionally provoked eosinophilic cell infiltration. Lymphocytes, plasma cells and B cells were also more prevalent in the BioGlue compared to the Coseal specimens. Coseal residue was either absent or visible in only small quantities, while significant BioGlue deposits remained in the tissue 2 weeks after application. Coseal was much more elastic than BioGlue, with a compressive modulus an order of magnitude lower (mean AE SD: 91 AE 41 vs 1833 AE 297 kPa). Compared to BioGlue, Coseal elicited a less pronounced inflammatory response in the aortic and periaortic tissue in this model, and demonstrated greater elasticity.

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Albumin-glutaraldehyde glue for repair of superficial lung defect: an in vitro experiment

Cited by 12 publications

References 19 publications

Polymeric Tissue Adhesives

Polymeric Tissue Adhesives

Covalently Crosslinked Hydrogels via Step‐Growth Reactions: Crosslinking Chemistries, Polymers, and Clinical Impact

Tissue reactions to polyethylene glycol and glutaraldehyde-based surgical sealants in a rabbit aorta model

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