Albumin-heparin microspheres as carriers for cytostatic agents

Cremers, H.F.M.; Feijén, Jan; Kwon, Glen S.; Bae, You Han; Kim, Sung Wan; Noteborn, H.P.J.M.; McVie, J. G.

doi:10.1016/0168-3659(90)90130-l

Cited by 39 publications

(21 citation statements)

References 19 publications

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“…Longo and Goldberg (6) have discussed the advantages of hydrophilic polymeric microspheres for drug delivery. A study on the release of Adriamycin from albuminheparin microspheres has been previously reported (7).…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of microspheres of albumin-heparin conjugates

Kwon¹,

Bae²,

Kim³

et al. 1991

Journal of Colloid and Interface Science

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Albumin-heparin microspheres have been prepared as a new drug carrier. A soluble albumin-heparin conjugate was synthesized by forming amide bonds between human serum albumin and heparin. After purification the albumin-heparin conjugate was crosslinked in a water-in-oil emulsion to form albuminheparin microspheres. The composition of the conjugate was determined by amino acid analysis. The swelling properties of albumin-heparin microspheres were investigated as a function of pH and ionic strength and compared with albumin microspheres. Albumin-heparin and albumin microspheres exhibited stimuli-sensitive swelling. Both microsphere systems exhibited low swelling at low pH and high swelling at higher pH caused by ionization of amino acids of serum albumin. The swelling of albumin-hepafin microspheres was more sensitive toward ionic strength than that of albumin microspheres. This was due to the greater negative charge of the albumin-heparin microspheres. Surfaces of albumin-heparin and albumin microspheres were characterized by ESCA, contact angle measurements, electrophoresis, and scanning electron microscopy. Surface analysis indicated the presence of heparin at the albumin-heparin microsphere/water interface.

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Section: Introductionmentioning

confidence: 99%

Preparation and characterization of microspheres of albumin-heparin conjugates

Kwon¹,

Bae²,

Kim³

et al. 1991

Journal of Colloid and Interface Science

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“…The biocompatibility of gelatin has been identified from its long-standing clinical application in surgical biomaterials and as an ingredient in drugs. 25 Researchers described that a gelatin hydrogel system prevents protein denaturation, and this interaction with ECM macromolecules leads to growth factors regulating its biological functions. 26 In this experiment, we observed positive effects of gelatin on primary culture of epidermal keratinocytes.…”

Section: Discussionmentioning

confidence: 99%

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2015

Exp Clin Transplant

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“…One of the major components of serum, albumin, has also been used as drug carrier or coating materials for a long time (Longo et al 1982, Lee et al 1981and Cremers at al 1990.…”

Section: Introductionmentioning

confidence: 99%

Preparation of enteric-coated microspheres of Mycoplasma hyopneumoniae vaccine with cellulose acetate phthalate: The effect of swine serum on micromeritic properties

et al. 1991

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Cellulose acetate phthalate was used to prepare the Mycoplasma hyopneumoniae vaccine (MHV) microspheres using a solvent evaporation method. Swine serum was used as an additive in the antigen to form the core materials.The addition of serum had a significant effect on surface topography of the MHV lnicrospheres.By using this modified solvent evaporation method, the recoveries of antigens in the MHV microspheres were generally over 90% of the weight and antigenicity of antigens originally added in the formulation.

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Albumin-heparin microspheres as carriers for cytostatic agents

Cited by 39 publications

References 19 publications

Preparation and characterization of microspheres of albumin-heparin conjugates

Preparation and characterization of microspheres of albumin-heparin conjugates

Untitled

Preparation of enteric-coated microspheres of Mycoplasma hyopneumoniae vaccine with cellulose acetate phthalate: The effect of swine serum on micromeritic properties

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