Albumin infusion ameliorates liver injury in streptozotocin-induced diabetic rats

Bae, C S; Ahn, Taeho

doi:10.17221/14/2021-vetmed

Cited by 4 publications

(3 citation statements)

References 49 publications

(50 reference statements)

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“…No distinct expression of CYP2E1 in the present results appears contrary to the previous reports that STZ elevated the expression and catalytic activity of CYP2E1 in the liver [ 31 ] and that CGA inhibited CYP2E1 activity in hepatic cell line [ 30 ]. Furthermore another study detected gene expression of CYP2E1, including CYP1A1/1A2 in PBMC and the liver from human patients with hepatocellular carcinoma [ 19 ].…”

Section: Discussioncontrasting

confidence: 99%

Chlorogenic acid attenuates pro-inflammatory response in the blood of streptozotocin-induced diabetic rats

2022

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Background Chlorogenic acid (CGA) has been shown to reduce pro-inflammation by scavenging reactive oxygen species (ROS) and reactive nitrogen species. In this study, the anti-inflammatory effect of CGA was expanded to streptozotocin (STZ)-induced diabetic rats. The inter-relationships among oxidative stress, pro-inflammation, and cytochrome P450 (CYP) 1A enzymes were also investigated in peripheral blood mononuclear cells (PBMC) of STZ-diabetic rats. Results The levels of pro-inflammatory cytokines, interleukin-6 and tumor necrosis factor-alpha, increased by approximately 3.4- and 2.9-fold, respectively, and the albumin concentration decreased in the serum of STZ-induced diabetic rats compared to normal rats. The C-reactive protein (CRP) values also increased by about 3.8-fold higher, indicating that STZ induced an inflammation in the blood of STZ-diabetic rats. The expression levels and catalytic activities of CYP1A enzymes were elevated by approximately 2.2–2.5- and 4.3–6.7-fold, respectively, in the PBMC of STZ-treated rats. A decrease in the amount of PBMC-bound albumin was also observed. In contrast, the levels of cytokines and CRP in serum and the activities of CYP1A enzymes in PBMC were significantly reduced in CGA-treated diabetic rats in a CGA concentration-dependent manner. In addition, STZ-mediated elevation of ROS in serum and PBMC was decreased by the CGA administration. However, the CGA treatment did not change the enhanced blood glucose level and expression of CYP1A enzymes by STZ. STZ-mediated decrease in the levels of serum and PBMC-bound albumin was not also restored by the CGA administration. Conclusions These results suggest that CGA could be used to treat type 1 diabetes-induced inflammation.

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Section: Discussioncontrasting

confidence: 99%

Chlorogenic acid attenuates pro-inflammatory response in the blood of streptozotocin-induced diabetic rats

2022

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“…More recently, albumin infusion was speculated to attenuate pro-inflammation response, oxidative stress, and consequent liver injury in STZ-induced diabetic rats (Bae and Ahn 2022 ; Bae et al 2019 ); albumin administration reduced the levels of oxidative stress and inflammatory markers, such as IL-6, TNF-α and CRP, which are increased by STZ treatment. In addition, albumin restored liver injury indexes, such as the activities of alanine aminotransferase and aspartate aminotransferase and the levels of triacylglycerol and ketones in the blood.…”

Section: Main Textmentioning

confidence: 99%

Therapeutic treatments for diabetes mellitus-induced liver injury by regulating oxidative stress and inflammation

2023

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Diabetes mellitus (DM) is a metabolic disease that affects all systems in the body, including the liver. Numerous studies have reported that chronic DM etiology and pathogenesis complications implicate oxidative stress, generating reactive oxygen species, such as superoxide anions and free radicals. In addition, pro-inflammatory reactions are also underlying functions closely related to oxidative stress that further exacerbate pathological DM states. The liver is especially susceptible to hyperglycemia-induced oxidative stress and the related inflammation. Thus, anti-oxidation and anti-inflammation therapies are promising strategies for treating liver damage. This review summarizes therapeutic treatments attenuating the generation of oxidative stress and pro-inflammation, which also cause DM-induced liver injury. Although the treatments have several impediments to be solved, these remedies may have clinically important implications under the absence of effective drugs for the damaged liver in DM patients.

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“…Abdel-Daim et al [92] stated that by scavenging the free radicals produced during intoxication by various harmful chemicals, spirulina helps to preserve the structural integrity of the hepatocellular membrane. The hepatoprotective effect of spirulina was related to (phycocyanin C), which has antioxidant activity eliminating alkoxyl-, hydroxyland peroxyl-free radicals, decreased nitrite production and inhibited hepatic microsomal lipid peroxidation [93].…”

Section: Histopathological Examination Of the Livermentioning

confidence: 99%

Hypolipidemic, Antioxidant and Immunomodulatory Effects of Lactobacillus casei ATCC 7469-Fermented Wheat Bran and Spirulina maxima in Rats Fed a High-Fat Diet

et al. 2022

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Hyperlipidemia is a leading cause of atherosclerosis and coronary heart disease (CHD). This study aimed to investigate the hypolipidemic effect of Lactobacillus casei ATCC 7469-fermented wheat bran extract and Spirulina maxima extract on Sprague–Dawley rats fed a regular or high-fat diet compared to rosuvastatin as a reference drug. Treatment with Lactobacillus casei ATCC 7469-fermented wheat bran and Spirulina maxima resulted in a significant decrease in total cholesterol (TC), triglycerides (TG.), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) (p < 0.05) and a significant increase in high-density lipoprotein (HDL) (p < 0.05). That combination also improved liver functions. It also resulted in the improvement of liver oxidative biomarkers and decreased the production of inflammatory markers (TNF-α, IFN-γ, IL-10, and IL-1β). In addition, a significant reduction in inflammation of liver tissues was observed after that treatment. Lactobacillus casei ATCC 7469-fermented wheat bran extract and Spirulina maxima extract had additive effects on the lipid profile, liver functions and immune system of rats similar to rosuvastatin.

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Albumin infusion ameliorates liver injury in streptozotocin-induced diabetic rats

Cited by 4 publications

References 49 publications

Chlorogenic acid attenuates pro-inflammatory response in the blood of streptozotocin-induced diabetic rats

Chlorogenic acid attenuates pro-inflammatory response in the blood of streptozotocin-induced diabetic rats

Therapeutic treatments for diabetes mellitus-induced liver injury by regulating oxidative stress and inflammation

Hypolipidemic, Antioxidant and Immunomodulatory Effects of Lactobacillus casei ATCC 7469-Fermented Wheat Bran and Spirulina maxima in Rats Fed a High-Fat Diet

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