Albumin Kinetics in Sepsis and COVID-19

Siddiqui, Suhail Sarwar; Chakraborty, Nilanchal; Muzaffar, Syed Nabeel; Gurjar, Mohan

doi:10.1097/cce.0000000000000651

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…Serum albumin. Hypoalbuminemia upon hospital admission, possibly in the context of changes in vascular permeability leading to a greater capillary leakage of albumin ( 60 ), among other factors, such as the underlying nutritional status, nitrogen balance, or renal replacement therapy ( 61 , 62 ), has been associated with poor outcomes in patients COVID-19 ( 63-65 ). Data on changes in albumin levels over the course of severe COVID-19 are limited, as discussed below.…”

Section: Results Of the Literature Searchmentioning

confidence: 99%

Temporal evolution of laboratory characteristics in patients critically ill with COVID‑19 admitted to the intensive care unit (Review)

Kokkoris,

Kanavou,

Kremmydas

et al. 2023

Med Int

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In the context of coronavirus disease 2019 (COVID-19), laboratory medicine has played a crucial role in both diagnosis and severity assessment. Although the importance of baseline laboratory findings has been extensively reported, data regarding their evolution over the clinical course are limited. The aim of the present narrative review was to provide the dynamic changes of the routine laboratory variables reported in patients with severe COVID-19 over the course of their critical illness. A search was made of the literature for articles providing data on the time-course of routine laboratory tests in patients with severe COVID-19 during their stay in the intensive care unit (ICU). White blood cell, neutrophil and lymphocyte counts, neutrophil to lymphocyte ratio, platelet counts, as well as D-dimer, fibrinogen, C-reactive protein, lactate dehydrogenase and serum albumin levels were selected as disease characteristics and routine laboratory parameters. A total of 25 research articles reporting dynamic trends in the aforementioned laboratory parameters over the clinical course of severe COVID-19 were identified. During the follow-up period provided by each study, the majority of the laboratory values remained persistently abnormal in both survivors and non-survivors. Furthermore, in the majority of studies, the temporal trends of laboratory values distinctly differentiated patients between survivors and non-survivors. In conclusion, there are distinct temporal trends in selected routine laboratory parameters between survivors and non-survivors with severe COVID-19 admitted to the ICU, indicating their importance in the prognosis of clinical outcome.

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Section: Results Of the Literature Searchmentioning

confidence: 99%

Temporal evolution of laboratory characteristics in patients critically ill with COVID‑19 admitted to the intensive care unit (Review)

Kokkoris,

Kanavou,

Kremmydas

et al. 2023

Med Int

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“…Lower serum levels of albumin are also associated with inflammatory conditions where serum cytokines IL-6 and TNF-α values are elevated, for example, infections, burns, fluid overload, hepatic failure, cancer and nephrotic syndrome ( Bharadwaj et al, 2016 ). In COVID-19 patients, hypoalbuminemia is associated with poor outcome and albumin kinetics tends to initially decrease, followed by recovery in disease survivors but not in non-survivors ( Garg et al, 2022 , Siddiqui et al, 2022 ). Our results are corroborated by these findings, converting albumin in a potential inflammatory biomarker and nutrition risk assessment tool for COVID-19 patients with and without SARS-CoV-2 vaccination ( Evans et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Serum biomarkers for nutritional status as predictors in COVID-19 patients before and after vaccination

Vaz-Rodrigues

Mazuecos

Villar

et al. 2023

Journal of Functional Foods

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“…The patient’s hypoalbuminemia throughout the whole hospitalization time (Fig. 2 C), and the elevated D-dimer and ferritin concentrations are additional risk factors for a severe disease course and a poor prognosis [ 15 – 17 ]. Figure 1 highlights the parameters of percentage and total count of altered blood cells measured during the hospital stay.…”

Section: Discussionmentioning

confidence: 99%

COVID-19: critical case of a patient with an atypical manifestation of the disease

2023

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Background COVID-19 was initially described as a severe acute respiratory disease that could drive to pneumonia, compromising the life of the patients in the worst scenario. However, even though in most of the cases the respiratory symptoms are still the most common manifestations of the disease, nowadays it is considered as a complex multisystem illness, affecting a variety of organs and tissues. Asymptomatic and atypic cases have also been described, where symptoms are not related to those first described, as is the case of this report. Case presentation On November 23, 2020, a 53-year-old woman goes to the emergency room due to gastrointestinal symptoms. The admission diagnosis was inflammatory bowel disease and a mild event of idiopathic chronic ulcerative colitis, and the initial treatment was focused on the metabolic acidosis, and the reestablishment the hydroelectrolytic and hemodynamic balance. Then, she was transferred to the Gastroenterology Unit where she was treated for one week. During her hospitalization, she showed a refractory shock caused by progressive organ deterioration (renal and neurological), requiring a double-vasopressor support, oxygenation, and ventilation. Considering the laboratory tests results and computed tomography scans, a COVID-19 test was carried out, obtaining a positive result with a high viral load. The S gene of the virus was amplified and sequenced, finding an uncommon mutation rarely reported worldwide. After considerable systemic deterioration, the patient presented cardiorespiratory arrest, with no response and died on December 1, after 8 days of hospitalization. Conclusions In this report we describe the pathogenesis, clinical manifestations, and outcome of a patient with atypical COVID-19 symptoms (mainly gastrointestinal), rapidly evolving and with lethal consequences. Therefore, it is important to emphasize the need to strengthen patient surveillance in health centers, including those who do not present typical symptoms of COVID-19. In addition, it will be important to track the identified mutation (H1058Y) in the S viral gene and assess whether it could be associated with a different clinical manifestation of the disease or if it was just an isolated event.

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Albumin Kinetics in Sepsis and COVID-19

Cited by 6 publications

References 10 publications

Temporal evolution of laboratory characteristics in patients critically ill with COVID‑19 admitted to the intensive care unit (Review)

Temporal evolution of laboratory characteristics in patients critically ill with COVID‑19 admitted to the intensive care unit (Review)

Serum biomarkers for nutritional status as predictors in COVID-19 patients before and after vaccination

COVID-19: critical case of a patient with an atypical manifestation of the disease

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