Albumin-loaded thermo/pH dual-responsive nanogels based on sodium alginate and poly (N-vinyl caprolactam)

Gholiha, Hamed Mohammad; Ehsani, Morteza; Saeidi, Ardeshir; Ghadami, Azam

doi:10.1007/s40204-022-00211-9

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Among the systems being investigated are liposomes 7 , polymeric nanoparticles (NPs) 8 , micelles 9 and covalently crosslinked nanogels (NGs) 10 , with the latter offering great potential 10 . NGs are characterized by small size (10 -100 nm) and high drug loading capacity, while their formulation can be easily tailored to introduce stimuli-responsiveness to triggers such as infrared radiation 11 , oxidation 12 , temperature 13 and pH 14,15 , an attractive feature for drug delivery applications [16][17][18][19] .…”

Section: Introductionmentioning

confidence: 99%

Sustainable and Surfactant-Free Synthesis of Negatively Charged Acrylamide Nanogels for Biomedical Applications

Mazzali,

Rath,

Röntgen

et al. 2024

Preprint

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Nanogels offer unique advantages, like high surface-to-volume ratio, scalable synthetic methods and easily tailored formulations, that allow to control size and introduce stimuli-responsive properties. Their potential for drug delivery is significant due to their biocompatibility, high drug loading capacity, and controlled and sustained drug release, but the development of greener and sustainable processes, in particular the replacement of organic solvents with water, is essential for large-scale applications. Here we report our results on the synthesis in water of covalently crosslinked acrylamide-based nanogels, both neutral and negatively charged, with varying amounts of acryloyl-L-proline, using a high-dilution radical polymerization technique without the need for surfactants. The use of a water-based synthesis resulted in nanogels with high monomer conversions and chemical yields, as well as lower polydispersity and smaller particle sizes for the negatively charged nanogels. This results in a more efficient synthetic methodology, with reduced loss of starting materials, higher potential for scalability and reduction in costs. The suitability of these nanogels for biomedical applications was supported by cytotoxicity studies showing no significant reduction in viability on a human neuroblastoma cell line.

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