Albumin locust valley: A new case of analbuminemia

Peters, Theodore; Holowachuk, Eugene W.; McIncrow, Richard; Campagnoli, Monica; Galliano, Monica

doi:10.1016/j.clinbiochem.2006.03.018

Cited by 4 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The plasma concentration commonly drops to values significantly lower than the concentration in healthy subjects, which is on the order of 45 gram per liter plasma. 52) Despite the low circulating albumin concentration, the patients do not generally show a severe phenotype, the only consistent finding being a slight tendency to develop ankle edema. 53) These findings may challenge the notion that albumin plays a critical role in the lipid economy of the body.…”

Section: Lessons From Patients and Experimental Animals Lacking Plasmmentioning

confidence: 98%

See 1 more Smart Citation

Albumin as Fatty Acid Transporter

Vusse¹

2009

Drug Metabolism and Pharmacokinetics

383

269

View full text Add to dashboard Cite

Fatty acids play critical roles in mammalian energy metabolism. Moreover, they are important substrates for the synthesis of membrane phospholipids and biologically active compounds like eicosanoids and leukotrienes. Because of their low solubility in aqueous solutions such as blood plasma and interstitial fluid, fatty acids are in need of binding proteins to increase their concentration in vascular and interstitial compartments. Albumin acts as main fatty acid binding protein in extracellular fluids. Plasma albumin possesses about 7 binding sites for fatty acids with moderate to high affinity, enhancing the concentration of fatty acids by a several orders of magnitude. Despite the high affinity of albumin for fatty acids, uptake of fatty acids by parenchymal cells such as skeletal and cardiac myocytes seems not to be hampered by albumin. In contrast, experimental findings suggest that albumin may facilitate the uptake of fatty acids by organs in need of these substrates. In the present overview the following issues will be briefly discussed: (i) transport and storage of fatty acids in the mammalian body, (ii) biosynthesis of albumin in the liver, (iii) localization and concentration of albumin in body fluids, (iv) interactions between albumin and fatty acids, (v) albumin structure and fatty acid binding sites, (vi) uptake of fatty acids by organs and roles for plasma albumin and (vii) lessons from patients and experimental animals lacking plasma albumin.

show abstract

Section: Lessons From Patients and Experimental Animals Lacking Plasmmentioning

confidence: 98%

“…52) This defect can be caused by nonsense mutations, mutations affecting splicing and frameshift/ deletion. The plasma concentration commonly drops to values significantly lower than the concentration in healthy subjects, which is on the order of 45 gram per liter plasma.…”

Section: Lessons From Patients and Experimental Animals Lacking Plasmmentioning

confidence: 99%

Albumin as Fatty Acid Transporter

Vusse¹

2009

Drug Metabolism and Pharmacokinetics

383

269

View full text Add to dashboard Cite

show abstract

“…CAA is a rare condition with 50 cases having been recorded since 1954, with an estimated frequency of 1 in 1,000,000 (3). Cases have been widely distributed throughout the world (3). Four cases of CAA from the northwestern central plains region in Saskatchewan have been previously reported (4)(5)(6).…”

mentioning

confidence: 99%

“…Few reports have provided antenatal and maternal history, although it has been hypothesized that the low incidence of CAA may in part be due to affected fetuses creating an inhospitable in-utero environment (1,2). CAA is a rare condition with 50 cases having been recorded since 1954, with an estimated frequency of 1 in 1,000,000 (3). Cases have been widely distributed throughout the world (3).…”

mentioning

confidence: 99%