Albumin nanocomposites with MnO2/Gd2O3 motifs for precise MR imaging of acute myocardial infarction in rabbit models

Wang, Fang; Wen, Linyi; Liu, Jing; Peng, Wanlin; Meng, Zihan; Chen, Qixian; Wang, Yao; Ke, Bowen; Guo, Ying; Mi, Peng

doi:10.1016/j.biomaterials.2019.119614

Cited by 54 publications

(46 citation statements)

References 49 publications

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“…Reliable chelate stability of Gd 3+ in their ligand is an important design factor one needs to consider. The existence of free Gd 3+ was assessed through the Arsenazo (III) colorimetric assay [ 33 ]. The combination of ASIII and Gd 3+ will present a new peak in the UV-vis spectrum of ASII at 660 nm (Fig.…”

Section: Resultsmentioning

confidence: 99%

Integration of PEG-conjugated gadolinium complex and superparamagnetic iron oxide nanoparticles as T1–T2 dual-mode magnetic resonance imaging probes

Yang

Cai

et al. 2021

Regenerative Biomaterials

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The T1−T2 dual-mode probes for magnetic resonance imaging (MRI) can non-invasively acquire comprehensive information of different tissues or generate self-complementary information of the same tissue at the same time, making MRI a more flexible imaging modality for complicated applications. In this work, three Gadolinium-diethylene-triaminepentaaceticacid (Gd-DTPA) complex conjugated superparamagnetic iron oxide (SPIO) nanoparticles with different Gd/Fe molar ratio (0.94, 1.28 and 1.67) were prepared as T1–T2 dual-mode MRI probes, named as SPIO@PEG-GdDTPA0.94, SPIO@PEG-GdDTPA1.28 and SPIO@PEG-GdDTPA1.67, respectively. All SPIO@PEG-GdDTPA nanocomposites with 8 nm spherical SPIO nanocrystals showed good Gd3+ chelate stability. SPIO@PEG-GdDTPA0.94 nanocomposites with lowest Gd/Fe molar ratio show no cytotoxicity to Raw 264.7 cells as compared to SPIO@PEG-GdDTPA1.28 and SPIO@PEG-GdDTPA1.67. SPIO@PEG-GdDTPA0.94 nanocomposites with r1 (8.4 mM−1s−1), r2 (83.2 mM−1s−1) and relatively ideal r2/r1 ratio (9.9) were selected for T1–T2 dual-mode MRI of blood vessels and liver tissue in vivo. Good contrast images were obtained for both cardiovascular system and liver in animal studies under a clinical 3 T scanner. Importantly, one can get high-quality contrast-enhanced blood vessel images within the first 2 h after contrast agent administration and acquire liver tissue anatomy information up to 24 h. Overall, the strategy of one shot of the dual mode MRI agent could bring numerous benefits not only for patients but also to the radiologists and clinicians, e.g. saving time, lowering side effects and collecting data of different organs sequentially.

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Section: Resultsmentioning

confidence: 99%

Integration of PEG-conjugated gadolinium complex and superparamagnetic iron oxide nanoparticles as T1–T2 dual-mode magnetic resonance imaging probes

Yang

Cai

et al. 2021

Regenerative Biomaterials

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“…Meanwhile, the zeta potential of Te–Gd in aqueous solution is about −14.6 mV. To date, many groups have reported BSA‐bioinspired gadolinium‐based hybrid nanoparticles for cancer therapy, such as Gd:CuS@BSA, [ 40 ] Gd/Ru@BSA, [ 46 ] Gd 2 O 3 @BSA, [ 47 ] and Gd 2 O 3 /Bi 2 S 3 . [ 48 ] The aforementioned BSA‐bioinspired gadolinium‐based hybrid nanoparticles are featured with high biosafety, excellent biocompatibility, and satisfactory therapeutic outcomes.…”

Section: Resultsmentioning

confidence: 99%

Engineering Gadolinium‐Integrated Tellurium Nanorods for Theory‐Oriented Photonic Hyperthermia in the NIR‐II Biowindow

Dong

Wen

et al. 2020

Small

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Near‐infrared (NIR) light‐triggered hyperthermia has exhibited promising prospects in oncology therapy due to the unique merits including minimal invasiveness, monitorable, excellent therapeutic effect, and negligible side effects. Especially, the second NIR biowindow (NIR‐II, 1000–1700 nm) with less absorbance and scattering by skin tissue, and deep tissue penetration, has received extensive attention for photonic hyperthermia. Unfortunately, the dissatisfactory photothermal conversion efficiency (PCE) and cumbersome preparation process of photo‐driven heat conversion nanomaterials seriously hamper the future clinical application. To combat the aforementioned challenges, high imaging performance and desired therapeutic outcome 1D nanorods are constructed based on gadolinium‐integrated tellurium nanorods (Te–Gd). In this system, magnetic resonance (MR) imaging and X‐ray computed tomography (CT) imaging‐guided photonic hyperthermia can be easily implemented in cooperation with Te–Gd. Importantly, Te–Gd possesses high PCE (41%) in the NIR‐II biowindow because the transition of the excited electron can easily occur from the valence band (VB) to the conduction band (CB) on (1 0 1) and (1 0 2) crystal planes. Furthermore, the distinctive photostability, high tumor accumulation, as well as low systemic adverse effects of Te–Gd guarantee the potential in the clinic.

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“…Internal stimuli‐responsive strategies have recently gained great attention in the field of cancer management for their unique advantages as release of tumor‐specific imaging reporters/drugs in response to the physiochemical and abnormal physiological condition of tumor microenvironments and tumor cells, such as a low pH (Mi et al, 2016; F. Wang, Wen, et al, 2020), tumor hypoxia (Yuan et al, 2017), as well as a high level of intracellular glutathione concentration (S. Guo, Xiao, et al, 2019; M. Li, Zhao, et al, 2019), intracellular reactive oxygen species (Y. Wang, Li, Du, & Liu, 2020; X. Yang, Hu, et al, 2019), and tumor‐specific enzymes (Cai et al, 2020; K. Chen, Cai, et al, 2019; R. Liu, Hu, Yang, Zhang, & Gao, 2019; Z. Luo, Dai, & Gao, 2019). Correspondingly, a set of internal‐stimuli responsive bonds have been extensively explored, including pH‐responsive bonds (hydrozone, acetal, cis‐acotinyl, and boronate ester), reduction‐responsive bonds (i.e., disulfide, diselenide), oxidation‐responsive bonds (selenide), and enzyme‐responsive bonds (substrates for specific enzymes) (Cai et al, 2018; Chen et al, 2020; C. Guo, Sun, et al, 2017; Qiu, Cheng, Zhang, & Zhuo, 2018; Mi, 2020).…”

Section: Design Strategies For Dendritic Nano‐scale Systems For Cancementioning

confidence: 99%

“…Internal stimuli-responsive strategies have recently gained great attention in the field of cancer management for their unique advantages as release of tumor-specific imaging reporters/drugs in response to the physiochemical and abnormal physiological condition of tumor microenvironments and tumor cells, such as a low pH (Mi et al, 2016;F. Wang, Wen, et al, 2020), tumor hypoxia (Yuan et al, 2017), as well as a high level of intracellular glutathione concentration (S. Guo, Xiao, et al, 2019;M.…”

Section: Internal Stimuli-responsive Degradable And/or Enhanced Imaging Strategiesmentioning

confidence: 99%

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

Sun

Zhu

et al. 2020

WIREs Nanomed Nanobiotechnol

173

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Dendritic polymers have highly branched three‐dimensional architectures, the fourth type apart from linear, cross‐linked, and branched one. They possess not only a large number of terminal functional units and interior cavities, but also a low viscosity with weak or no entanglement. These features endow them with great potential in various biomedicine applications, including drug delivery, gene therapy, tissue engineering, immunoassay and bioimaging. Most review articles related to bio‐related applications of dendritic polymers focus on their drug or gene delivery, while very few of them are devoted to their function as cancer diagnosis agents, which are essential for cancer treatment. In this review, we will provide comprehensive insights into various dendritic polymer‐based cancer diagnosis agents. Their classification and preparation are presented for readers to have a precise understanding of dendritic polymers. On account of physical/chemical properties of dendritic polymers and biological properties of cancer, we will suggest a few design strategies for constructing dendritic polymer‐based diagnosis agents, such as active or passive targeting strategies, imaging reporters‐incorporating strategies, and/or internal stimuli‐responsive degradable/enhanced imaging strategies. Their recent applications in in vitro diagnosis of cancer cells or exosomes and in vivo diagnosis of primary and metastasis tumor sites with the aid of single/multiple imaging modalities will be discussed in great detail. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > in vivo Nanodiagnostics and Imaging Diagnostic Tools > in vitro Nanoparticle‐Based Sensing

show abstract

Albumin nanocomposites with MnO2/Gd2O3 motifs for precise MR imaging of acute myocardial infarction in rabbit models

Cited by 54 publications

References 49 publications

Integration of PEG-conjugated gadolinium complex and superparamagnetic iron oxide nanoparticles as T1–T2 dual-mode magnetic resonance imaging probes

Integration of PEG-conjugated gadolinium complex and superparamagnetic iron oxide nanoparticles as T1–T2 dual-mode magnetic resonance imaging probes

Engineering Gadolinium‐Integrated Tellurium Nanorods for Theory‐Oriented Photonic Hyperthermia in the NIR‐II Biowindow

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

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