Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans

Fellström, Bengt; Helmersson‐Karlqvist, Johanna; Lind, Lars; Soveri, Inga; Thulin, Måns; Ärnlöv, Johan; Kultima, Kim; Larsson, Anders

doi:10.3390/biom11030396

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…The plasma levels of TNF-alpha (molecular weight: 27 kDa) [ 33 , 34 ] and IL-6 (molecular weight: 23.7 kDa) [ 34 ] were not significantly different in SPS vs non-SPS dexamethasone-naïve patients in our cohort. The expression of CRP is increased during acute phase responses, mainly mediated by IL-6 [ 35 ] and further modulated by dexamethasone, although the timing of such application modifies the secretion of CRP after stimulation by IL-6 [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Shrunken Pore Syndrome Is Frequently Occurring in Severe COVID-19

Larsson

Hultström

Frithiof

et al. 2022

IJMS

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A selective decrease in the renal filtration of larger molecules is attributed to the shrinkage of glomerular pores, a condition termed Shrunken Pore Syndrome (SPS). SPS is associated with poor long-term prognosis. We studied SPS as a risk marker in a cohort of patients with COVID-19 treated in an intensive care unit. SPS was defined as a ratio < 0.7 when the estimated glomerular filtration rate (eGFR), determined by cystatin C, calculated by the Cystatin C Caucasian-Asian-Pediatric-Adult equation (CAPA), was divided by the eGFR determined by creatinine, calculated by the revised Lund–Malmö creatinine equation (LMR). Clinical data were prospectively collected. In total, SPS was present in 86 (24%) of 352 patients with COVID-19 on ICU admission. Patients with SPS had a higher BMI, Simplified Physiology Score (SAPS3), and had diabetes and/or hypertension more frequently than patients without SPS. Ninety-nine patients in the total cohort were women, 50 of whom had SPS. In dexamethasone-naïve patients, C-reactive protein (CRP ), TNF-alpha, and interleukin-6 did not differ between SPS and non-SPS patients. Demographic factors (gender, BMI) and illness severity (SAPS3) were independent predictors of SPS. Age and dexamethasone treatment did not affect the frequency of SPS after adjustments for age, sex, BMI, and acute severity. SPS is frequent in severely ill COVID-19 patients. Female gender was associated with a higher proportion of SPS. Demographic factors and illness severity were independent predictors of SPS.

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Section: Discussionmentioning

confidence: 99%

Shrunken Pore Syndrome Is Frequently Occurring in Severe COVID-19

Larsson

Hultström

Frithiof

et al. 2022

IJMS

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“…5,6 The levels of Crea, TP, and mALB mainly reflect the degree of kidney damage caused by various diseases. [7][8][9] The biochemical analysis of these urinary analytes can have an important adjuvant role in the diagnosis and evaluation of a number of clinical problems. It may, however, be confounded in ICU settings and ideally should be integrated into the broader clinical context to inform about optimal management.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of analytical performance & quality specification of urine biochemical analytes

Pandith¹

2023

IJCBR

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Urinary biochemical analytes are very important tools for clinical decision making. Total allowable error (TEa) by integrating internal (IQC) and external (EQC) quality control performances are used to evaluate the performance of urinary biochemical analytes along with quality specifications strategy. : Alternate 6 months Coefficient of Variation (CV%) and External Quality Assurance Scheme (EQAS) bias% data for urinary biochemistry analytes were collected for the year 2022. TEa calculated for each analyte was calculated based on average CV% and bias%. Total TEa calculated values are compared with optimal, minimal and desirable TEa of each analyte. : TEa values of urinary biochemistry analytes were performing good and fulfilled minimal, desirable and optimal quality requirements except urine creatinine which did not fulfill the minimal standards.: TEa is an excellent quality management tool and quantitatively evaluates analytical performance. The accurate results generated are useful for clinicians for decision-making.

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“…8 The levels of urea, Crea, TP, and mALB mainly reflect the degree of kidney damage caused by various diseases. [9][10][11] With the widespread application of urinary biochemical analytes in clinics, the testing capabilities of laboratories are increasingly becoming a challenge. Therefore, laboratories urgently need to design a quality evaluation strategy to evaluate the analytical performance of urinary biochemical analytes.…”

Section: Introductionmentioning

confidence: 99%