Albuminuria and other renal damage biomarkers detect acute kidney injury soon after acute ingestion of oxalic acid and potassium permanganate

Wijerathna, Thilini; Mohamed, Fahim; Dissanayaka, Dhammika Menike; Gawarammana, Indika; Palangasinghe, Chathura; Shihana, Fathima; Endre, Zoltán H.; Shahmy, Seyed; Buckley, Nicholas A.

doi:10.1016/j.toxlet.2018.10.002

Cited by 11 publications

(5 citation statements)

References 47 publications

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“…The poor definition of the time of NGAL measurement and the absence of definite snakebite confirmation, make it difficult to compare our results with these two studies [31,32]. Few recent clinical and [18,20,33] pre-clinical [34] studies investigated urinary NGAL in poisoning and showed a modest diagnostic performance (AUC-ROC = 0.7 to 0.8) in toxicant-induced AKI within 24 h of poisoning [18,20,33,34]…”

Section: Discussionmentioning

confidence: 88%

Early identification of acute kidney injury in Russell’s viper (Daboia russelii) envenoming using renal biomarkers

et al. 2019

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Background Acute kidney injury (AKI) is a major complication of snake envenoming, but early diagnosis remains problematic. We aimed to investigate the time course of novel renal biomarkers in AKI following Russell’s viper ( Daboia russelii ) bites. Methodology/Principal findings We recruited a cohort of patients with definite Russell’s viper envenoming and collected serial blood and urine samples on admission (<4h post-bite), 4-8h, 8-16h, 16-24h, 1 month and 3 months post-bite. AKI stage (1–3) was defined using the Acute Kidney Injury Network criteria. AKI stages (1–3) were defined by the Acute Kidney Injury Network (AKIN) criteria. There were 65 Russell’s viper envenomings and 49 developed AKI: 24 AKIN stage 1, 13 stage 2 and 12 stage 3. There was a significant correlation between venom concentrations and AKI stage (p = 0.007), and between AKI stage and six peak biomarker concentrations. Although most biomarker concentrations were elevated within 8h, no biomarker performed well in diagnosing AKI <4h post-bite. Three biomarkers were superior to serum creatinine (sCr) in predicting AKI (stage 2/3) 4-8h post-bite: serum cystatin C (sCysC) with an area under the receiver operating curve (AUC-ROC), 0.78 (95%CI:0.64–0.93), urine neutrophil gelatinase-associated lipocalin (uNGAL), 0.74 (95%CI:0.59–0.87) and urine clusterin (uClu), 0.81 (95%CI:0.69–0.93). No biomarker was better than sCr after 8h. Six other urine biomarkers urine albumin, urine beta2-microglobulin, urine kidney injury molecule-1, urine cystatin C, urine trefoil factor-3 and urine osteopontin either had minimal elevation, and/or minimal prediction for AKI stage 2/3 (AUC-ROC<0.7). Conclusions/Significance AKI was common and sometimes severe following Russell’s viper bites. Three biomarkers uClu, uNGAL and sCysC, appeared to become abnormal in AKI earlier than sCr, and may be useful in early identification of envenoming.

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Section: Discussionmentioning

confidence: 88%

Early identification of acute kidney injury in Russell’s viper (Daboia russelii) envenoming using renal biomarkers

et al. 2019

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“…The exception was for the juice treated in the GDP at a plasma flow rate of 10 mL/min, where no significant change was observed in the concentration of this compound. The reduction in the contents of oxanilic acid can be viewed as positive, since its excessive consumption can be harmful and has been associated with the formation of calcium oxalate kidney stones [34]. On the other hand, the significant decrease in 2aminobenzoxazole is a disadvantage of the plasma process because this compound has been linked to antimicrobial, anti-inflammatory, and anticancer properties [35].…”

Section: Resultsmentioning

confidence: 99%

Influence of Cold Plasma Processing on the Stability of Phenolic Compounds of Araça-Boi (Eugenia stipitata) Juice

Porto,

Maia,

Rodrigues

et al. 2023

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Knowledge of the chemical changes caused during plasma treatment is essential to enhance food quality. In this work, the influence of two cold plasma technologies, dielectric barrier discharge plasma and glow discharge plasma, on the phenolic profile of araça-boi (Eugenia stipitata) juice was investigated and assessed by gas chromatography coupled to mass spectrometry. Eight phenolic compounds were identified in araça-boi, with cinnamic acid being the major phenolic compound of the fruit juice, followed by protocatechuic acid. The effects of excitation frequency and plasma flow rate were evaluated because these are the main operating conditions that can be set for plasma treatments. The phenolic profile slightly changed due to the reaction of the phenolics with the reactive plasma species produced during the treatment, with the highest increase in phenolic content observed in the dielectric barrier discharge plasma operating at 1000 Hz. Both plasma systems increased the bioavailability of phenolic compounds in the juice, which could be increased by up to 201% using the dielectric barrier discharge plasma. Plasma application increased the concentration of cinnamic, hydrocinnamic, benzoic, and p-coumaric acids. Overall, plasma treatment improved the bioavailability of the phenolic compounds and resulted in slight changes to the phenolic profile of araça-boi juice. Thus, the technology showed a positive effect on araça-boi juice. This work advanced our further understanding of the changes induced by cold plasma treatment on phenolic compounds and characterization of araça-boi (Eugenia stipatata).

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“…Albuminuria is a known AKI biomarker 27 , independently associated with a lower rate of AKI recovery in critically ill septic patients 28 . Increased albuminuria may be the consequence of glomerular or tubular alterations 29 , 30 . In our model, because of cisplatin’s mechanisms of nephrotoxicity 17 , 31 , albuminuria probably results from altered proximal tubular reclamation.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of persistent renal vulnerability after acute kidney injury recovery

Fuentes‐Calvo

Cuesta

Sancho-Martínez

et al. 2021

Sci Rep

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Acute kidney injury (AKI) is a risk factor for new AKI episodes, chronic kidney disease, cardiovascular events and death, as renal repair may be deficient and maladaptive, and activate proinflammatory and profibrotic signals. AKI and AKI recovery definitions are based on changes in plasma creatinine, a parameter mostly associated to glomerular filtration, but largely uncoupled from renal tissue damage. The evolution of structural and functional repair has been incompletely described. We thus aimed at identifying subclinical sequelae persisting after recovery from cisplatin-induced AKI in rats. Compared to controls, after plasma creatinine recovery, post-AKI kidneys showed histological alterations and attendant susceptibility to new AKI episodes. Tubular function (assessed by the furosemide stress test, FST) also remained affected. Lingering parenchymal and functional subclinical alterations were paralleled by tapering, but abnormally high levels of urinary albumin, transferrin, insulin-like growth factor-binding protein 7 (IGFBP7), tissue inhibitor of metalloproteinases-2 (TIMP-2) and, especially, the [TIMP-2]*[IGFBP7] product. As subclinical surrogates of incomplete renal recovery, the FST and the urinary [TIMP-2]*[IGFBP7] product provide two potential diagnostic tools to monitor the sequelae and kidney vulnerability after the apparent recovery from AKI.

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Albuminuria and other renal damage biomarkers detect acute kidney injury soon after acute ingestion of oxalic acid and potassium permanganate

Cited by 11 publications

References 47 publications

Early identification of acute kidney injury in Russell’s viper (Daboia russelii) envenoming using renal biomarkers

Early identification of acute kidney injury in Russell’s viper (Daboia russelii) envenoming using renal biomarkers

Influence of Cold Plasma Processing on the Stability of Phenolic Compounds of Araça-Boi (Eugenia stipitata) Juice

Biomarkers of persistent renal vulnerability after acute kidney injury recovery

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