Albuterol nebulized in heliox in the initial ED treatment of pediatric asthma: a blinded, randomized controlled trial

Rivera, Michelle; Kim, Tommy Y.; Stewart, Gail; Minasyan, Lilit; Brown, Lance

doi:10.1016/j.ajem.2005.06.007

Cited by 47 publications

(15 citation statements)

References 22 publications

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“…A number of researchers have studied the clinical drug administration effects of heliox-driven aerosol over the recent years, while the findings were strikingly different [8]. Findings from some studies support the benefits of heliox-driven aerosol [9,10], whereas other studies have not found clinical benefits from the use of heliox [11,12]. Moreover, the treatment effects were obviously different with different proportions of oxygen and helium.…”

Section: Introductionmentioning

confidence: 99%

Heliox-Driven Nebulization Has a Positive Effect on the Lung Function in Lipopolysaccharide-Induced Chronic Obstructive Pulmonary Disease Rat Model

Chen

Liu

et al. 2016

Med Sci Monit

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BackgroundChronic obstructive pulmonary disease (COPD) is a serious lung disease that severely threatens people’s health. This study aimed to investigate the effects of heliox-driven nebulization (HDN) on lung function and arterial blood gases in a COPD rat model.Material/MethodsTwelve healthy male Wistar rats were selected as controls and 34 rats were used to establish a COPD model induced by lipopolysaccharide. Then 6 rats each from the control and model groups were selected for their symptoms to be observed. The remaining 6 normal rats were used as control group (group A) and the remaining 28 experimental COPD rats were randomly assigned to 4 groups: experimental COPD group (group B), medical oxygen group (group C), and heliox groups (group D, He/O2=63%/37%; group E, He/O2=71%/29%). The lung function indicators and arterial blood gases were analyzed to evaluate the effects of different driving gases on COPD rats.ResultsThe COPD model was successfully established with slow growth and severe lung dysfunction. Inspiratory resistance, expiratory resistance, and forced expiratory volume at 0.10 s (FEV0.10)/FVC were significantly decreased, whereas dynamic lung compliance was significantly increased in groups D and E, compared with the experimental COPD group (group B; P<0.05). Meanwhile, compared with the model group, the values of partial pressure of carbon dioxide in arterial blood were significantly higher, whereas the potential of hydrogen values were significantly lower after atomization in groups C and D but not in group E (P<0.05). The obvious increase in arterial oxygen saturation was found only in group E (P<0.05).ConclusionsHDN improved the lung function and arterial blood gas analysis results in experimental COPD rats, with an optimal percentage of He/O2=71%/29%.

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Section: Introductionmentioning

confidence: 99%

Heliox-Driven Nebulization Has a Positive Effect on the Lung Function in Lipopolysaccharide-Induced Chronic Obstructive Pulmonary Disease Rat Model

Chen

Liu

et al. 2016

Med Sci Monit

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“…In one study, patients aged 3-16 years who had received three nebulized albuterol doses plus intravenous methyprednisolone were randomly assigned to receive 70:30 heliox (20 patients) or 70:30 N 2 :O 2 (21 patients) for the continuous nebulization of albuterol 0.45 mg/kg (maximum dosage 15 mg/hr). 29 No difference was seen in a modified dyspnea index score at 10 or 20 minutes. In the other study, 30 children aged 2-18 years with moderate-to-severe asthma were randomly assigned to continuous nebulization of albuterol 15 mg/hour by 70:30 heliox or oxygen.…”

Section: Discussionmentioning

confidence: 89%

Effect of Heliox on Albuterol Delivery by Metered-Dose Inhaler in Pediatric In Vitro Models of Mechanical Ventilation

et al. 2006

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“…63 Some studies have shown modest benefit [63][64][65] whereas others show no benefit. 66 It has a level D recommendation as the driver of nebulized salbutamol in severe asthma, 3 mainly because of its lack of side effects.…”

Section: Second-line Treatmentsmentioning

confidence: 99%

Common Pediatric Respiratory Emergencies

Choi

Lee

2012

Emergency Medicine Clinics of North America

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Albuterol nebulized in heliox in the initial ED treatment of pediatric asthma: a blinded, randomized controlled trial

Cited by 47 publications

References 22 publications

Heliox-Driven Nebulization Has a Positive Effect on the Lung Function in Lipopolysaccharide-Induced Chronic Obstructive Pulmonary Disease Rat Model

Heliox-Driven Nebulization Has a Positive Effect on the Lung Function in Lipopolysaccharide-Induced Chronic Obstructive Pulmonary Disease Rat Model

Effect of Heliox on Albuterol Delivery by Metered-Dose Inhaler in Pediatric In Vitro Models of Mechanical Ventilation

Common Pediatric Respiratory Emergencies

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