Alcaloïdes des Annonacées XXIX: Alcaloïdes de l'Annona muricata L.

Lebœuf, Michel; Legueut, C.; Cavé, André; Desconclois, J. F.; Forgacs, P.; Jacquemin, Henri

doi:10.1055/s-2007-971543

Cited by 61 publications

(25 citation statements)

References 10 publications

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“…Norreticuline was not detected in any sample. It has already been reported that reticuline is present in soursop [21], though its content was not determined.…”

Section: Resultsmentioning

confidence: 91%

Detection and determination of reticuline and N-methylcoculaurine in the Annonaceae family using liquid chromatography-tandem mass spectrometry

Kotake

Okuda

Kamizono

et al. 2004

Journal of Chromatography B

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“…Norreticuline was not detected in any sample. It has already been reported that reticuline is present in soursop [21], though its content was not determined.…”

Section: Resultsmentioning

confidence: 91%

Detection and determination of reticuline and N-methylcoculaurine in the Annonaceae family using liquid chromatography-tandem mass spectrometry

Kotake

Okuda

Kamizono

et al. 2004

Journal of Chromatography B

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“…9 However, the presence of the alkaloid in the soursop leaf (Annona muricata (L) Folium) which can either be reticuline, coclaurine, coreximine, atherosperminine, stepharine, anomurine, and anomuricine can penetrate the placenta and affect the osmotic pressure disturbance, which then causes viscocity disturbance and hemorrhage in different parts of the body. 9,10 Microcephaly happened in one of the fetuses in the third group which was treated by soursop leaf extract (Annona muricata (L) Folium) at the organogenesis phase. Microcephaly is a disturbance caused by the failure of the brain to grow, leading to the failure of the skull to expand.…”

Section: Discussionmentioning

confidence: 99%

Soursop Leaves (Annona muricata Folium) on Mice (Mus musculus) Fetus

Suryani¹,

Sitorus²,

Irianti³

2014

amj

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Background: Soursop leaf ethanol extract (Annona muricata (L) Folium) contains acetogenins which are cytotoxic and have the ability to halt cell growth. This study aimed to understand whether acetogenins have teratogenic effects on mice fetus (Mus musculus). Methods: This study was performed at the Pharmacology and Therapy Laboratory of the Faculty of Medicine, Universitas Padjadjaran, Bandung, between October and November 2012. The study was an experimental laboratory study utilizing 27 pregnant mice which were divided into 3 groups. The first group was the negative control, the second was given soursop leaf ethanol extract at pre-implantation phase (day 1 to 5) and the third had the extract provided in the organogenesis phase (day 6 to 15). Laparotomy was performed on the 19 th day of pregnancy. The parameters used were the number of implantation, the number of live and dead or resorbed fetus, the weight and length of the fetus, as well as the macroscopic external morphology abnormalities. The data gained from test subjects were compared to those of the control group. The statistical test used was the normality tes with the Kolmogorov-Smirnov method which was then followed by T-test or Mann-Whitney statistical tests. Results:The experiment exhibited significant differences in the weight and length of the fetus (p-value 0.000), proving that soursop leaf ethanol extract could inhibit intrauterine growth. Aside from that, external morphological abnormalities such as hemorrhage on the head, face, neck, back, forelimbs, hindlimbs, and microcephaly were also found. Conclusion:The soursop leaf ethanol extract (Annona muricata (L) Folium) has a teratogenic effect on mouse (Mus musculus) fetus. [AMJ.2014;1(1): [48][49][50][51][52][53]

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“…A few chemical and biological reports have been published on these three Xylopia: eleven isoquinoline alkaloids were described from different parts of X . frutescens; tannins and saponins were characterized and four quercetol or kaempferol flavonoid glycosides were found in the leaves; a weak sedative and analgesic activity was assigned to stem bark alkaloids (Leboeuf et al, 1982). Major components of the X .…”

Section: Introductionmentioning

confidence: 99%

Volatile constituents of Xylopia frutescens, X. pynaertii and X. sericea: Chemical and biological study

Fournier

Hadjiakhoondi

Lebœuf

et al. 1994

Phytotherapy Research

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The essential oils from three Xylopiu species (X. frutescens, X. pynuertii, X. sericea), Annonaceae, have been examined by GC and GUMS, and screened for bacteriostatic and fungistatic activities. The main components of each oil have been identified. The major constituents of X . frutescens stem bark oil were a-cubebene (25.2%) and h-cadinol (27.4%). The root of X. pynaertii was rich in elemol (27.1%), while the stem bark oil contained hcadinene (10.3%), y-muurolene (10.1%) and cubenol(12.6°/o). The major components of X. sericea root bark oil were p-cymene (22.8%) and a-gurjunene (13.8%). These oils exhibited moderate bacteriostatic and fungistatic activities.

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Alcaloïdes des Annonacées XXIX: Alcaloïdes de l'Annona muricata L.

Cited by 61 publications

References 10 publications

Detection and determination of reticuline and N-methylcoculaurine in the Annonaceae family using liquid chromatography-tandem mass spectrometry

Detection and determination of reticuline and N-methylcoculaurine in the Annonaceae family using liquid chromatography-tandem mass spectrometry

Soursop Leaves (Annona muricata Folium) on Mice (Mus musculus) Fetus

Volatile constituents of Xylopia frutescens, X. pynaertii and X. sericea: Chemical and biological study

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