Alcalóides indólicos isolados de espécies do gênero Aspidosperma (Apocynaceae)

Pereira, Maria de Meneses; Jácome, Rose Lisieux R. Paiva; Alcântara, Antônio Flávio de Carvalho; Alves, Rosemeire Brondi; Raslan, D. S.

doi:10.1590/s0100-40422007000400037

Cited by 66 publications

(58 citation statements)

References 35 publications

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“…Up to 1983, 46 species of Aspidosperma had been chemically investigated (Bolzani et al 1987). This number increased to 55 by 1996 (Pereira et al 2007). Hundreds of indolomonoterpenoid alkaloids have been isolated and their structures have been determined mainly by spectrometric methods.…”

Section: Alkaloids: New Leads For Antimalarial Drugs?mentioning

confidence: 92%

“…These compounds represent a valuable library of rich structural diversity and great interest for bioprospection. In fact, an antineoplasic drug, Elliptinium (Celiptium ) (9-hydroxy-2-methylellipticinium acetate) is a semi-synthetic derivative of the cytotoxic alkaloid ellipticine (Chart 8); it was initially isolated from the Ochrosia species (Apocynaceae) but it also occurs in the Aspidosperma species (Pereira et al 2007). Elliptinium is marketed in France for the treatment of breast cancer (Cragg and Newman 2005).…”

Section: Alkaloids: New Leads For Antimalarial Drugs?mentioning

confidence: 99%

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Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids

Oliveira

Dolabela

Braga

et al. 2009

An. Acad. Bras. Ciênc.

128

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Malaria remains one of the most serious world health problem and the major cause of mortality and morbidity in the endemic regions. Brazil is among the 30 high-burden countries and most of the cases occur in the Legal Amazonian Region. New chemotherapeutical agents are needed for the treatment of malaria. Many plant species are used in traditional medicines of malarious countries and a relatively few number of these have been investigated for evaluation of their antimalarial effect. Still lower is the number of those that have had the active natural compounds isolated and the toxicity determined. This area is, then, of great research interest. A discovery project of antimalarial natural products from plants traditionally used to treat malaria must include in vitro and in vivo assays as well as bioguided isolation of active compounds. The final products would be antimalarial chemical entities, potential new drugs or templates for new drugs development, and/or standardized antimalarial extracts which are required for pre-clinical and clinical studies when the aim is the development of effective and safe phythomedicines. This review discusses these two approaches, presents briefly the screening methodologies for evaluation of antimalarial activity and focuses the activity of alkaloids belonging to different structural classes as well as its importance as new antimalarial drugs or leads and chemical markers for phytomedicines.

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Section: Alkaloids: New Leads For Antimalarial Drugs?mentioning

confidence: 92%

Section: Alkaloids: New Leads For Antimalarial Drugs?mentioning

confidence: 99%

Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids

Oliveira

Dolabela

Braga

et al. 2009

An. Acad. Bras. Ciênc.

128

View full text Add to dashboard Cite

show abstract

“…Additionally, Aspidosperma extracts showed very good antiprotozoal activity in vitro, including leishmanicidal and trypanocidal activities (Weniger et al, 2001). This genus is characterized by the occurrence of indole alkaloids (Cordell, 1979;Mitaine et al, 1996;Pereira et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Indole Alkaloids from Aspidosperma rigidum and A. schultesii and their Antiparasitic Effects

Reina

Ruiz-Mesia

Mesia

et al. 2011

Zeitschrift Für Naturforschung C

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Five oxindole alkaloids, three plumerane-type alkaloids, subtype haplophitine, and one aspidospermatane-type alkaloid, subtype tubotaiwine, were isolated from the medicinal plants Aspidosperma rigidum and A. schultesii. One compound was identifi ed as the transoid conformer of 18-oxo-O-methylaspidoalbine which was not previously described. The antiparasitic activity of all compounds against Trypanosoma cruzi and Leishmania infantum and their non-specifi c cytotoxicity against mammalian cells were also determined.

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“…[9][10][11][12][13] Aspidosperma ulei (Markgr.) (Apocynaceae), which grows largely in the Amazon region of Brazil and elsewhere in South America, is a plant rich in indole alkaloids 14 and has an ethnomedicinal history as a traditional remedy for the treatment of ED. In the search for novel drugs effective against ED, our previous studies evaluated semi-purified extracts of Aspidosperma ulei, in vitro as well as in vivo, and the results obtained were encouraging.…”

Section: Introductionmentioning

confidence: 99%

Relaxant effect and possible mechanism of 17-nor-subincanadine E in rabbit corpora cavernosa

Benvindo¹,

Nascimento²,

Santos³

et al. 2011

Asian J Androl

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Compounds with dual action on cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) may be a treatment option for erectile dysfunction, as they not only promote penile erection but also prevent the upregulation of phosphodiesterase-5. In this study, we examined the possible relaxant effect and mechanism of 17-nor-subincanadine E (SEC, 0.2-200 mmol l 21 ), a plant-derived alkaloid, in rabbit corpus cavernosum (RbCC) strips that had been precontracted by exposure to phenylephrine (10 mmol l 21 ) or a high concentration of K 1 (60 mmol l 21 ) in vitro. In addition to SEC's effect on cAMP and cGMP levels, electrical field stimulation (EFS) in phenylephrine-precontracted RbCC and calcium chloride (1-100 mmol l 21 ) evoked responses in depolarized RbCC were analysed. SEC relaxed the phenylephrine-precontracted RbCCs in a concentration-dependent manner. Atropine, guanethidine and N-v-nitro-L-arginine methyl ester (L-NAME) did not have any effect on the relaxation of RBCCs. When 1H-1,2,4 oxadiazole[4,3-a] quinoxalin-1-one (ODQ) was added, it effectively blocked the relaxant response of SEC. Although SEC enhanced the maximal relaxation produced by sodium nitroprusside (SNP) and forskolin in phenylephrine-precontracted cavernosal smooth muscle, it caused a decrease in the maximal contractile response induced by calcium chloride in depolarized RbCCs. The relaxant effect of SEC was paralleled by an increase in the tissue levels of the cyclic nucleotides cAMP and cGMP. We conclude that SEC promotes the relaxation of RbCC, possibly favouring cAMP and cGMP accumulation and calcium blockade. This novel mechanism could be useful for patients who do not benefit from phosphodiesterase inhibitors and for those with endothelial and nitrergic dysfunction, such as patients with diabetes, hypertension and dyslipidaemias. Asian Journal of Andrology (2011) 13, 747-753; doi:10.1038/aja.2011.41; published online 18 July 2011Keywords: 17-nor-subincanadine E; cyclic nucleotides; electrical field stimulation; nitric oxide; rabbit corpus cavernosum; smooth muscle relaxation INTRODUCTIONThe erect penis has always been a symbol of power, virility and fertility. Erectile dysfunction (ED) is the consistent inability to achieve and maintain an erection sufficient for satisfactory sexual activity. This condition is a complex neurovascular disorder that affects 52% of men aged 40-70 years and causes considerable distress, unhappiness and relationship problems for these men. 1,2 Penile erection occurs as a function of trabecular smooth muscle relaxation and a subsequent increase in blood flow to lacunar spaces, which results in engorgement of the penis and restriction of venous drainage. Basically, the process is mediated by nitric oxide (NO) release from cavernosal nerve varicosities and endothelial cells, and this release activates intracellular guanylate cyclase to produce cGMP. 3 Recently, the selective phosphodiesterase 5 (PDE5) inhibitors sildenafil, tadalafil and vardenafil were shown to enhance the proerectile effect ...

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Alcalóides indólicos isolados de espécies do gênero Aspidosperma (Apocynaceae)

Cited by 66 publications

References 35 publications

Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids

Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids

Indole Alkaloids from Aspidosperma rigidum and A. schultesii and their Antiparasitic Effects

Relaxant effect and possible mechanism of 17-nor-subincanadine E in rabbit corpora cavernosa

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