Alcaloïdes Indoliques de Rauvolfia biauriculata

Abaul, Jacqueline; Philogène, É.; Bourgeois, P.; Merault, G.; Poupat, C.; Ahond, A.; Potìer, Pierre

doi:10.1021/np50047a011

Cited by 18 publications

(8 citation statements)

References 3 publications

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“…On the basis of HSQC experiment, the left eight carbon signals were comprised of four methines and four methylenes. These NMR data of compound 2 were similar to those of lochnerine (4) [20], except that the methoxyl group in 4 was displaced by a hydroxyl group in 2. The HMBC correlations of H-9 to C-7, C-11, and C-13, H-11 to C-9 and C-13, and H-12 to C-8 and C-10 confirmed this hydroxyl group was at C-10.…”

Section: Identification Of New Compoundssupporting

confidence: 57%

Bioactivity-Guided Isolation and Identification of New and Immunosuppressive Monoterpenoid Indole Alkaloids from Rauvolfia yunnanensis Tsiang

Shi

Liu

et al. 2019

Molecules

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Three new 11-hydroxyburnamine (1) and rauvoyunnanines A–B (2–3), and fourteen known (4–17) monoterpenoid indole alkaloids were isolated from the total alkaloids extract of Rauvolfia yunnanensis, which exhibited promising immunosuppressive activity on T cell proliferation in preliminary screening. Their structures were determined by analysis of high-resolution electrospray ionization mass (HRESIMS), ultraviolet (UV) and nuclear magnetic resonance (NMR) data, and by comparison with the literature. All the alkaloids were evaluated for inhibitory activity on T cell proliferation. Among them, one new compound (1) and reserpine (6) exhibited moderate immunosuppressive activity, with IC50 values of 5.9 μM and 5.0 μM, respectively.

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Section: Identification Of New Compoundssupporting

confidence: 57%

Bioactivity-Guided Isolation and Identification of New and Immunosuppressive Monoterpenoid Indole Alkaloids from Rauvolfia yunnanensis Tsiang

Shi

Liu

et al. 2019

Molecules

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show abstract

“…Isomeranzin, heraclenol and canellal were obtained by chromatography of a chloroform extract of dried, powdered leaves as reported earlier [7]. Ibogaine, voacangine, lochnerin, pilocarpine and texalin were obtained as reported [8, 9]. Briefly, the dried powdered material was moistened with 25% NH 4 OH, and extracted by chloroform.…”

Section: Methodsmentioning

confidence: 99%

Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe

Rastogi¹,

Abaul²,

Goh³

et al. 1998

FEMS Immunology &Amp; Medical Microbiology

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Eight chemically defined, naturally occurring compounds were extracted from the tropical flora of the Caribbean island of Guadeloupe: pilocarpine, an alkaloid from Pilocarpus racemosus ; heraclenol and isomeranzin, coumarins from Triphasia trifolia; lochnerin, an indole alkaloid from Rauwolfia biauriculata; ibogaine and voacangine, indole alkaloids from Tabernaemontana citrifolia ; texalin, an oxazole from Amyris elemifera; and canellal, a sesquiterpene dialdehyde from Canella winterana. An essential oil fraction from Canella winterana was also tested. The antimycobacterial activity of these substances was tested against Mycobacterium tuberculosis, M. avium and M. kansasii using the Middlebrook 7H11 agar medium, the Bactec 460-TB radiometric methodology, and determination of bacterial viable counts. Three compounds, namely ibogaine, voacangine and texalin, showed antimycobacterial activity. Investigations on the structure-modification and structure-activity relationships of these compounds may help determine new targets for future drug development. z 1998 Federation of European Microbiological Societies. Published by Elsevier Science B.V.

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“…Isomeranzin, heraclenol and canellal were obtained by chromatography of a chloroform extract of dried, powdered leaves as reported earlier [7]. Ibogaine, voacangine, lochnerin, pilocarpine and texalin were obtained as reported [8,9]. Brie£y, the dried powdered material was moistened with 25% NH R OH, and extracted by chloroform.…”

Section: Natural Compoundsmentioning

confidence: 99%

Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe

Rastogi¹

1998

FEMS Immunology and Medical Microbiology

View full text Add to dashboard Cite

Eight chemically defined, naturally occurring compounds were extracted from the tropical flora of the Caribbean island of Guadeloupe: pilocarpine, an alkaloid from Pilocarpus racemosus; heraclenol and isomeranzin, coumarins from Triphasia trifolia; lochnerin, an indole alkaloid from Rauwolfia biauriculata; ibogaine and voacangine, indole alkaloids from Tabernaemontana citrifolia; texalin, an oxazole from Amyris elemifera; and canellal, a sesquiterpene dialdehyde from Canella winterana. An essential oil fraction from Canella winterana was also tested. The antimycobacterial activity of these substances was tested against Mycobacterium tuberculosis, M. avium and M. kansasii using the Middlebrook 7H11 agar medium, the Bactec 460-TB radiometric methodology, and determination of bacterial viable counts. Three compounds, namely ibogaine, voacangine and texalin, showed antimycobacterial activity. Investigations on the structure-modification and structure-activity relationships of these compounds may help determine new targets for future drug development.

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Alcaloïdes Indoliques de Rauvolfia biauriculata

Cited by 18 publications

References 3 publications

Bioactivity-Guided Isolation and Identification of New and Immunosuppressive Monoterpenoid Indole Alkaloids from Rauvolfia yunnanensis Tsiang

Bioactivity-Guided Isolation and Identification of New and Immunosuppressive Monoterpenoid Indole Alkaloids from Rauvolfia yunnanensis Tsiang

Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe

Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe

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