Alcohol abuse and dysfunctional eating in adolescent girls: The influence of individual differences in sensitivity to reward and punishment

Loxton, Natalie J.; Dawe, Sharon

doi:10.1002/eat.1042

Cited by 235 publications

(183 citation statements)

References 22 publications

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“…The literature is in disagreement, however, with respect to whether BN is associated with increased sensitivity to reward or with blunted reward responsiveness. Few studies report that binge-eating and purging behaviors are associated with elevated sensitivity to reward (Farmer et al, 2001;Harrison et al, 2010;Loxton and Dawe, 2001). A study investigating reward sensitivity and brain activation to images of food in a sample of 14 patients with BN reported greater arousal in affective ratings of food pictures, as well as exaggerated anterior cingulate cortex and insula activation compared with healthy controls, binge-eating patients and overweight subjects without eating disorder (Schienle et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Dopamine-Related Deficit in Reward Learning After Catecholamine Depletion in Unmedicated, Remitted Subjects with Bulimia Nervosa

Grob

Pizzagalli

Dutra

et al. 2012

Neuropsychopharmacol

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Disturbances in reward processing have been implicated in bulimia nervosa (BN). Abnormalities in processing reward-related stimuli might be linked to dysfunctions of the catecholaminergic neurotransmitter system, but findings have been inconclusive. A powerful way to investigate the relationship between catecholaminergic function and behavior is to examine behavioral changes in response to experimental catecholamine depletion (CD). The purpose of this study was to uncover putative catecholaminergic dysfunction in remitted subjects with BN who performed a reinforcement-learning task after CD. CD was achieved by oral alpha-methyl-para-tyrosine (AMPT) in 19 unmedicated female subjects with remitted BN (rBN) and 28 demographically matched healthy female controls (HC). Sham depletion administered identical capsules containing diphenhydramine. The study design consisted of a randomized, double-blind, placebo-controlled crossover, single-site experimental trial. The main outcome measures were reward learning in a probabilistic reward task analyzed using signal-detection theory. Secondary outcome measures included self-report assessments, including the Eating Disorder Examination-Questionnaire. Relative to healthy controls, rBN subjects were characterized by blunted reward learning in the AMPTFbut not in placeboFcondition. Highlighting the specificity of these findings, groups did not differ in their ability to perceptually distinguish between stimuli. Increased CD-induced anhedonic (but not eating disorder) symptoms were associated with a reduced response bias toward a more frequently rewarded stimulus. In conclusion, under CD, rBN subjects showed reduced reward learning compared with healthy control subjects. These deficits uncover disturbance of the central reward processing systems in rBN related to altered brain catecholamine levels, which might reflect a trait-like deficit increasing vulnerability to BN.

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Section: Discussionmentioning

confidence: 99%

Dopamine-Related Deficit in Reward Learning After Catecholamine Depletion in Unmedicated, Remitted Subjects with Bulimia Nervosa

Grob

Pizzagalli

Dutra

et al. 2012

Neuropsychopharmacol

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“…Besides the 'BEP' characteristics that parallel these disorders including increased intake of PF under sated conditions, selection of PF over less PF after stress, and ability in some BEPs to resist overweight despite a tendency to binge-eat on PF, another parallel may be reward sensitivity which is also implicated to characterize individuals with eating disorders. 32,65,66,67 Our food-hedonic environment is not expected to change, it would be valuable to know how the BEP-DIR rats are able to overindulge in PF food but still maintain normal caloric intake to keep them from gaining weight. This describes the eating behavior of some of us described as 'lucky' by those battling overweight and/or binge-eating.…”

Section: Discussionmentioning

confidence: 99%

High intake of palatable food predicts binge-eating independent of susceptibility to obesity: an animal model of lean vs obese binge-eating and obesity with and without binge-eating

et al. 2007

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Objective: To determine the stability of individual differences in non-nutritive 'junk' palatable food (PF) intake in rats; assess the relationship of these differences to binge-eating characteristics and susceptibility to obesity; and evaluate the practicality of using these differences to model binge-eating and obesity. Design: Binge-eating prone (BEP) and resistant (BER) groups were identified. Differential responses to stress, hunger, macronutrient-varied PFs, a diet-induced obesity (DIO) regimen and daily vs intermittent access to a PF þ chow diet, were assessed. Subjects: One hundred and twenty female Sprague-Dawley rats. Measurements: Reliability of intake patterns within rats; food intake and body weight after various challenges over acute (1, 2, 4 h), 24-h and 2-week periods. Results: Although BEP and BER rats did not differ in amount of chow consumed, BEPs consumed 450% more intermittent PF than BERs (Po0.001) and consistently so (a ¼ 0.86). BEPs suppressed chow but not PF intake when stressed, and ate as much when sated as when hungry. Conversely, BERs were more affected by stress and ate less PF, not chow, when stressed and were normally hyperphagic to energy deficit. BEP overeating generalized to other PFs varying in sucrose, fat and nutrition content. Half the rats in each group proved to be obesity prone after a no-choice high fat diet (DIO diet) but a continuous diet of PF þ chow normalized the BEPs high drive for PF. Conclusion: Greater intermittent intake of PF predicts binge-eating independent of susceptibility to weight gain. Daily fat consumption in a nutritious source (DIO-diet; analogous to a fatty meal) promoted overeating and weight gain but limiting fat to daily non-nutritive food (PF þ chow; analogous to a snack with a low fat meal), did not. The data offer an animal model of lean and obese binge-eating, and obesity with and without binge-eating that can be used to identify the unique physiology of these groups and henceforth suggest more specifically targeted treatments for binge-eating and obesity.

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“…Studies show that higher reward sensitivity, particularly in relation to Fun Seeking, is associated with higher alcohol intake and more frequent binge drinking (Feil & Hasking, 2008;Franken & Muris, 2006;Loxton & Dawe, 2001;O'Conner, Stewart & Watt, 2009;Voigt et al, 2009). Similarly, studies show that Fun Seeking is associated with a greater likelihood of being a smoker (O'Connor et al, 2009) and more frequent use of cigarettes, cigars or chewing tobacco (Voigt et al, 2009) Thus, another goal of the present study was to extend previous research by employing a community sample of participants to explore the relationship between BAS and consumption of alcohol and cigarettes.…”

mentioning

confidence: 99%

Sensitivity to reward and punishment: Associations with diet, alcohol consumption, and smoking

Tapper

Baker

Jiga‐Boy

et al. 2015

Personality and Individual Differences

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Alcohol abuse and dysfunctional eating in adolescent girls: The influence of individual differences in sensitivity to reward and punishment

Abstract: These findings suggest that girls who abuse alcohol and have dysfunctional eating may share a vulnerability to heightened sensitivity to reward, yet be differentiated by sensitivity to punishment.

Cited by 235 publications

References 22 publications

Dopamine-Related Deficit in Reward Learning After Catecholamine Depletion in Unmedicated, Remitted Subjects with Bulimia Nervosa

Dopamine-Related Deficit in Reward Learning After Catecholamine Depletion in Unmedicated, Remitted Subjects with Bulimia Nervosa

High intake of palatable food predicts binge-eating independent of susceptibility to obesity: an animal model of lean vs obese binge-eating and obesity with and without binge-eating

Sensitivity to reward and punishment: Associations with diet, alcohol consumption, and smoking

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