Alcohol Abuse Predicts Progression of Disease and Death in Patients with Lung Cancer

Paull, Douglas E.; Updyke, Glenda M.; Baumann, Michael A.; Chin, Hong W.; Little, Alex G.; Adebonojo, Samuel A.

doi:10.1016/j.athoracsur.2005.03.071

Cited by 37 publications

(26 citation statements)

References 36 publications

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“…Most patients had early stage disease, and had good long term survival, consistent with a study of “resectable” lung cancer (Figure 1). The predominance of squamous cell histology is due to predominantly male, heavy smoking patients in a VA population as previously reported (Paull, Updyke et al 2005). …”

Section: Resultssupporting

confidence: 73%

Gene Expression Profiles from Needle Biopsies Provide Useful Signatures of Non-Small Cell Lung Carcinomas

et al. 2007

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Gene expression profiles from DNA microarrays can provide molecular signatures that improve tumor classification, prognosis, and treatment options. While much of this work has focused on isolation of RNA from the resected tumor, fewer studies have utilized RNA from fine needle aspirates (FNA). In this pilot study we examined whether the gene signatures obtained from FNA samples would correlate with signatures taken from the resected tumor. Based on NSCLC gene expression profiles obtained from eleven sets of FNA and tumor samples we obtained a high concordance of FNA profiles matching their matched tumor sample. These results suggest that FNA samples may provide informative gene expression signatures regarding the potential aggressiveness of non-small-cell lung carcinomas.

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Section: Resultssupporting

confidence: 73%

Gene Expression Profiles from Needle Biopsies Provide Useful Signatures of Non-Small Cell Lung Carcinomas

et al. 2007

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“…Higher rates of asthma [74] and upper airway symptoms are associated with heavy drinkers [75,76]. Interestingly, chronic bronchitis shows a J-shaped curve association with alcohol, in that the lowest prevalence of bronchitis is associated with moderate consumption of alcohol compared to non-consumption, while heavy intake is associated with a higher prevalence [73].…”

Section: Respiratory Complications Of Alcohol Misusementioning

confidence: 98%

Alcohol as a toxic and disease‐forming agent: Not just the liver and brain and not every drinker

Srirajaskanthan

Preedy

2007

Journal of Nutritional & Environmental Medicine

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Purpose: Excessive alcohol, defined as beyond the limits suggested by various government and statutory bodies, is damaging. This article aims to show that there may be as many as 120-200 adverse medical conditions and pathologies associated with alcohol misuse. Design and method: This review examines the different organ systems within the body and the effect of alcohol on nutrition, bone, skin, the gastrointestinal tract and skeletal muscle. Results: We identified that nearly all organ systems have the potential to be affected by alcohol or its ensuing metabolite acetaldehyde; as a result, the presence of two or more pathologies or conditions in alcohol misusers is not unusual. However, there are genetic factors that make individuals more susceptible to developing alcoholism and alcohol-related disease. These include genes for acetaldehyde formation and oxidation and possibly some neurotransmitters such as GABA, dopamine and 5-HT. For example, in simple terms, subjects with the dysfunctional ALDH2*2 allele which oxidises acetaldehyde less effectively than those with the ALDH2*1 allele generate high concentrations of acetaldehyde. This acts as a deterrent to alcoholism as acetaldehyde produces nausea and adverse cardiovascular symptoms. At the same time those with the ALDH2*2 allele who do consume alcohol have poorer outcome measures than those with the ALDH2*1 allele, due to the cytotoxic effects of acetaldehyde. Conclusions: Excessive ethanol consumption can lead to development of disease in many different organs, through its direct effect and also its toxic metabolites. However, not all individuals are susceptible and there are likely to be genetic as well as environmental factors that increase individuals' predisposition to develop alcohol related co-morbidity.Abbreviations: ADH: alcohol dehydrogenase, ALDH: aldehyde dehydrogenase, GABA: caminobutyric acid, 5-HT: serotonin

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“…The prevalence of alcohol use and misuse appears be higher in major otolaryngology surgeries (mostly for cancer and injuries: 30-88.5%) [31-34, 41, 42, 44, 45], vascular, and thoracic surgeries (cancer resections: 29-33%) [47,48] likely reflecting the association of alcohol misuse with head and neck tumors and smoking which increases the risk of head, neck, and lung cancers. In the remaining studies of other surgery types that reported prevalence, alcohol use and misuse ranged from 7.7-28%.…”

Section: Discussionmentioning

confidence: 99%

“…A study of patients undergoing surgery for lung cancer found that 32.7% of patients with resectable disease had one of several criteria for alcohol misuse recorded in the medical record: CAGE 2 or 5 drinks per day or meeting DSM IV criteria for an alcohol use disorder [48]. Canver [47] found that 29.1% of lung cancer resection patients drank more than 2 drinks per day pre-operatively.…”

Section: Specific Surgical Proceduresmentioning

confidence: 99%

“…While 12 studies used assessments based on interviews or self-report questionnaires, 10 were based on clinical information abstracted from the medical record, and four studies did not state the source of the alcohol data. Measures varied from dichotomous measures of lifetime or current alcohol use [23,24,35], screening questionnaires for lifetime alcohol use disorders such as the CAGE and Short Michigan Alcoholism Screening Test (SMAST) [29,48], categorization based on drinking over 2 or 3 drinks per day or over 6 drinks a week, judgments that alcohol use was associated with an injury [34], DSM criteria for alcohol use disorders or binge drinking [48], and self-reported history of alcohol abuse [28] or alcohol use impacting health [26]. A major limitation of studies identified was the lack of description of how alcohol use/misuse was assessed and the timeframe of the alcohol measure (Tables 1 and 2), so that it was often unclear if patients who were categorized as at-risk due to drinking continued to drink at the time of surgery.…”

Section: Strengths and Limitations Of Identified Studiesmentioning

confidence: 99%

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Alcohol Misuse Prevalence and Associations with Post-Operative Complications in US Surgical Patients: A Review

Harris¹,

Frey²,

DeBenedetti³

et al. 2009

TOSJ

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Abstract:We conducted a standardized review of research on the prevalence of alcohol use or misuse (including alcohol use disorders), and the association of alcohol use or misuse with post-operative surgical complications among US patients. Twenty seven studies that included a preoperative measure of alcohol use or misuse and included at least 50 US surgical patients were identified using a standardized search strategy (1950( -April 2007. Twenty-two of the studies reported prevalence of alcohol use or misuse, which was highest in major otolaryngology surgeries (mostly for cancer and injuries: 22-88.5%) and thoracic surgery (lung transplant and cancer resections: 29-33%) and ranged from 8-28% in the remaining studies. Nineteen studies examined the association between pre-operative alcohol consumption and post-operative complications suggesting positive associations between alcohol use or misuse and risk for post-operative delirium, pneumonia, cognitive decline, overall complications, and death. Most identified studies had methodological limitations, especially the widespread use of drinking assessment methods that cannot distinguish alcohol use from misuse.

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Alcohol Abuse Predicts Progression of Disease and Death in Patients with Lung Cancer

Cited by 37 publications

References 36 publications

Gene Expression Profiles from Needle Biopsies Provide Useful Signatures of Non-Small Cell Lung Carcinomas

Gene Expression Profiles from Needle Biopsies Provide Useful Signatures of Non-Small Cell Lung Carcinomas

Alcohol as a toxic and disease‐forming agent: Not just the liver and brain and not every drinker

Alcohol Misuse Prevalence and Associations with Post-Operative Complications in US Surgical Patients: A Review

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