Alcohol amplifies neuroinflammatory IL-6 pathway signaling in the prefrontal cortex

Cucinello-Ragland, Jessica A.; Tran, Ngan T.K.; Bajo, Michal; Roberto, Marisa; Edwards, Scott

doi:10.1016/j.alcohol.2021.09.012

Cited by 1 publication

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“…[ 79 ] A recent data had shown that alcohol amplifies neuroinflammatory IL‐6 signalling in the prefrontal cortex. [ 80 ]…”

Section: Discussionmentioning

confidence: 99%

“…[79] A recent data had shown that alcohol amplifies neuroinflammatory IL-6 signalling in the prefrontal cortex. [80] One likely mechanism of ethanol-induced brain damage involves increased oxidative stress in neurons. [76] The brain is particularly susceptible to lipid peroxidation, since it consumes a large amount of oxygen and is rich in polyunsaturated fatty acids, which are especially prone to reactive oxygen injury.…”

Section: Effect Of Ahm and Ethanol On Cortical Expressions Of Nf-κb A...mentioning

confidence: 99%

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Aggressive‐like behaviour and neurocognitive impairment in alcohol herbal mixture‐fed mice are associated with increased neuroinflammation and neuronal apoptosis in the prefrontal cortex

Ajayi

Melete

Ben‐Azu

et al. 2022

J Biochem & Molecular Tox

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Alcohol-induced aggression and related violence is a serious and common social problem globally. Alcohol use is increasingly found in the form of alcoholic herbal mixtures (AHM) with indiscriminate and unregulated alcohol content. This study investigated the effects of AHM on aggressive-like, neurocognitive impairment and brain biochemical alteration in mice. Thirty-two male resident mice were paired housed with female mice for 21 days in four groups (n = 8). Resident mice were treated orally with normal saline, AHM, ethanol and AHM + ethanol daily for 14 days. Aggressive-like behaviour was scored based on the latency and frequency of attacks by the resident mouse on the intruder. Neurocognitive impairment was determined using the Y-maze test (YMT) and novel object recognition test (NORT).Acetylcholinesterase, glutamic acid decarboxylase (GAD), pro-inflammatory and oxidative stress parameters were determined in the prefrontal cortex (PFC).Neuronal morphology, cytochrome c (Cyt-c) and nuclear factor-kappa B (NF-ĸB) expressions were determined. AHM and in combination with ethanol showed an increased index of aggression typified by frequency of attack and reduced latency to attack when compared to normal saline-treated animals. Co-administration of AHM and ethanol significantly reduced cognitive correct alternation (%) and discrimination index in the YMT and NORT, respectively. AHM and ethanol increased acetylcholinesterase, Pro-inflammatory cytokines and oxidative stress parameters while they reduced GAD. There were significantly reduced neuronal counts and increased expression of Cyt-c and NF-ĸB, respectively Alcoholic herbal mixture increased aggressiveness and caused neurocognitive impairment via increased oxidoinflammatory stress in the prefrontal cortex.

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“…[ 79 ] A recent data had shown that alcohol amplifies neuroinflammatory IL‐6 signalling in the prefrontal cortex. [ 80 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Effect Of Ahm and Ethanol On Cortical Expressions Of Nf-κb A...mentioning

confidence: 99%

Aggressive‐like behaviour and neurocognitive impairment in alcohol herbal mixture‐fed mice are associated with increased neuroinflammation and neuronal apoptosis in the prefrontal cortex

Ajayi

Melete

Ben‐Azu

et al. 2022

J Biochem & Molecular Tox

View full text Add to dashboard Cite

show abstract

Alcohol amplifies neuroinflammatory IL-6 pathway signaling in the prefrontal cortex

Cited by 1 publication

References 0 publications

Aggressive‐like behaviour and neurocognitive impairment in alcohol herbal mixture‐fed mice are associated with increased neuroinflammation and neuronal apoptosis in the prefrontal cortex

Aggressive‐like behaviour and neurocognitive impairment in alcohol herbal mixture‐fed mice are associated with increased neuroinflammation and neuronal apoptosis in the prefrontal cortex

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