Alcohol and cannabis consumption in patients with inflammatory bowel disease: prevalence, pattern of consumption and impact on the disease

Martinho-Grueber, Maude; Kapoglou, Ioannis; Bravo, Francisco; Sarraj, Riad; Benz, Eileen; Restellini, Sophie; Biedermann, Luc; Rogler, Gerhard; Vavricka, Stephan R.; Schoepfer, Alain; Maillard, Michel H.; Michetti, Pierre; Brunner, Felix; Clair, Carole; Barry, Mamadou Pathe; Pittet, Valérie; Känel, Roland von; Juillerat, Pascal

doi:10.1097/meg.0000000000002453

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…As indicated by Casey et al [ 36 ], the effect of ethanol on the gut may be potentially associated with the development of inflammatory bowel disease and impairment of the gut barrier function and permeability [ 37 ], along with its proinflammatory actions, including decreasing T-cell activity [ 38 ] and increasing TNF-α, interleukin-1, and interleukin-6 levels [ 39 ]. At the same time, in ulcerative colitis patients, it was observed that low-to-moderate alcohol drinking compared with heavy drinking was associated with less extensive disease [ 40 ]. Finally, the consumption of alcoholic beverages is known to interfere with the metabolism of colitis-specific medications, which may lead to a loss of their therapeutic effect or to an increased risk of side effects [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Nutritional Value of Diets and Food Choices in Polish Female Ulcerative Colitis Individuals Compared with a Pair-Matched Control Sample

2023

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Ulcerative colitis patients often attribute their symptoms to specific dietary products. Therefore, even though there are no specific dietary recommendations, these patients commonly have dietary restrictions, often with no consultation from their physician or dietitian, as they believe that they may be beneficial for them. The aim of the study was to analyze the nutritional value of diets and food choices in Polish female ulcerative colitis individuals, in comparison with a pair-matched control sample. The study was conducted on a group of 44 Polish female ulcerative colitis individuals being in remission and 44 individuals within a pair-matched control sample, matched by their age and concurrent diseases, excluding those resulting from ulcerative colitis. The analysis of the diet was based on the self-reported data, including 3-day dietary records (to assess the intake of nutrients and food products), as well as the simple open-ended question about food products excluded from their diet. It was stated that Polish female ulcerative colitis individuals were characterized by a lower energy value of diet (p = 0.0043), accompanied by the higher proportion of total protein (p = 0.0128) than the pair-matched control sample. As a result of a lower energy value for ulcerative colitis individuals, the intake of numerous nutrients was also lower (p < 0.05); however, after recalculation per 1000 kcal, ulcerative colitis individuals were characterized by higher total protein (p = 0.0121), starch (p = 0.0009), and vitamin B6 intake (p = 0.0319), as well as lower alcohol intake (p = 0.0464). Similarly, as a result of a lower energy value for ulcerative colitis individuals, the intake of numerous foods was also lower (p < 0.05); however, after recalculation per 1000 kcal, ulcerative colitis individuals were characterized by higher meat (p = 0.0058) and potatoes intake (p = 0.0052), as well as lower legumes (p = 0.0301), chocolate sweets (p = 0.0165), and alcoholic beverages intake (p = 0.0062). For chocolate sweets (p = 0.0134) and alcoholic beverages (p = 0.0091), ulcerative colitis individuals were characterized by a higher frequency of declaration of dietary exclusion. At the same time, ulcerative colitis individuals were characterized by a lower frequency of meeting the recommended intake for magnesium (p = 0.0005), iron (p = 0.0189), vitamin E (p = 0.0389), and vitamin B1 (p = 0.0032). It was concluded that even in remission, there is a risk of inadequate consumption, not meeting the recommended intake, and nutritional deficiencies in the population of female ulcerative colitis patients.

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Section: Discussionmentioning

confidence: 99%

Analysis of the Nutritional Value of Diets and Food Choices in Polish Female Ulcerative Colitis Individuals Compared with a Pair-Matched Control Sample

2023

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“…In this field, the specific alcohol interaction with the central nervous system via the gut-brain axis remains unclear, but studies propose that alcohol-triggered leaky gut may result in a systemic inflammation affecting neuronal function [ 122 ]. This condition could contribute to symptoms like anxiety during alcohol withdrawal [ 123 ], and even moderate alcohol consumption can lead to increased gut motility and disrupt the balance of gut microbiota, potentially developing symptoms like diarrhea, bloating, and abdominal pain [ 124 , 125 ].…”

Section: Which Foods and Food Patterns Can Cause Intolerance?mentioning

confidence: 99%

Food Intolerances, Food Allergies and IBS: Lights and Shadows

Pasta,

Formisano,

Calabrese

et al. 2024

Nutrients

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This narrative review delves into the intricate relationship between irritable bowel syndrome (IBS) and food intolerances. IBS, a chronic functional gastrointestinal disorder, is characterized by symptoms like abdominal pain and altered bowel habits. The prevalence of IBS has increased globally, especially among young adults. Food and dietary habits play a crucial role in IBS management. About 85–90% of IBS patients report symptom exacerbation linked to specific food consumption, highlighting the strong connection between food intolerances and IBS. Food intolerances often exhibit a dose-dependent pattern, posing a challenge in identifying trigger foods. This issue is further complicated by the complex nature of gastrointestinal physiology and varying food compositions. This review discusses various dietary patterns and their impact on IBS, including the low-FODMAP diet, gluten-free diet, and Mediterranean diet. It highlights the importance of a personalized approach in dietary management, considering individual symptom variability and dietary history. In conclusion, this review emphasizes the need for accurate diagnosis and holistic management of IBS, considering the complex interplay between dietary factors and gastrointestinal pathophysiology. It underlines the importance of patient education and adherence to treatment plans, acknowledging the challenges posed by the variability in dietary triggers and the psychological impact of dietary restrictions.

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“…In patients with CD, the relative statistical weight of smoking was larger than the relative weight of the genetic variants presented in the previous section[ 1 ]. Besides, cannabis is frequently used as a symptomatic treatment by patients with CD involving the ileum and is associated with tobacco[ 117 ]. Regarding cannabis use, in a double-blind, randomized, placebo-controlled trial, cannabis oil induced clinical improvement without any endoscopic change[ 118 ].…”

Section: Environmental Factorsmentioning

confidence: 99%

Crohn’s disease: Why the ileum?

Richard¹,

Savoye²,

Leboutte³

et al. 2023

World J Gastroenterol

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Crohn’s disease (CD) is an inflammatory bowel disease characterized by immune-mediated flares affecting any region of the intestine alternating with remission periods. In CD, the ileum is frequently affected and about one third of patients presents with a pure ileal type. Moreover, the ileal type of CD presents epidemiological specificities like a younger age at onset and often a strong link with smoking and genetic susceptibility genes. Most of these genes are associated with Paneth cell dysfunction, a cell type found in the intestinal crypts of the ileum. Besides, a Western-type diet is associated in epidemiological studies with CD onset and increasing evidence shows that diet can modulate the composition of bile acids and gut microbiota, which in turn modulates the susceptibility of the ileum to inflammation. Thus, the interplay between environmental factors and the histological and anatomical features of the ileum is thought to explain the specific transcriptome profile observed in CD ileitis. Indeed, both immune response and cellular healing processes harbour differences between ileal and non-ileal CD. Taken together, these findings advocate for a dedicated therapeutic approach to managing ileal CD. Currently, interventional pharmacological studies have failed to clearly demonstrate distinct response profiles according to disease site. However, the high rate of stricturing disease in ileal CD requires the identification of new therapeutic targets to significantly change the natural history of this debilitating disease.

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Alcohol and cannabis consumption in patients with inflammatory bowel disease: prevalence, pattern of consumption and impact on the disease

Cited by 7 publications

References 32 publications

Analysis of the Nutritional Value of Diets and Food Choices in Polish Female Ulcerative Colitis Individuals Compared with a Pair-Matched Control Sample

Analysis of the Nutritional Value of Diets and Food Choices in Polish Female Ulcerative Colitis Individuals Compared with a Pair-Matched Control Sample

Food Intolerances, Food Allergies and IBS: Lights and Shadows

Crohn’s disease: Why the ileum?

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