Background and aimsAlthough multiracial people comprise the fastest growing population in the United States, multiracial youth are nearly invisible in alcohol research. This meta‐analysis synthesized the youth alcohol literature to estimate the magnitude of difference in alcohol use as a function of multiracial status.Design and MeasurementsEmpirical studies reporting multiracial and monoracial comparisons in youth (aged 10–24 years) alcohol use were identified through a systematic literature search. A random‐effects meta‐analysis was conducted using 85 effect sizes extracted from 16 studies assessing life‐time, past‐year, past‐month and binge alcohol use.Setting and ParticipantsA total of n=1 555 635 youth were assessed in the United States.FindingsMultiracial youth are suggested to be more likely to endorse life‐time alcohol use than Asian youth [number of studies (k) = 3; odds ratio (OR) = 1.81, 95% confidence interval (CI) = 1.01, 3.24; p = 0.04], with significant between‐study heterogeneity (Q = 8.42; p < 0.001; I2 = 76%) in effect size comparisons. Multiracial youth are suggested to be more likely to endorse past‐month alcohol use than Black (k = 6; OR = 1.54, 95% CI = 1.38, 1.71; p < 0.001) and Asian (k = 4; OR = 2.09, 95% CI = 1.52, 2.88; p < 0.001) youth, but less likely than White (k = 6; OR = 0.87, 95% CI = 0.84, 0.91; p < 0.001) youth, with significant between‐study heterogeneity for Black youth (Q = 11.94; p = 0.03; I2 = 58%) in effect size comparisons. Lastly, multiracial youth are suggested to be more likely to endorse binge alcohol use than Black (k = 4; OR = 1.98, 95% CI = 1.62, 2.44; p < 0.001) and Asian (k = 4; OR = 2.82, 95% CI = 2.28, 3.48; p < 0.001) youth, but less likely than White (k = 5; OR = 0.75, 95% CI = 0.70, 0.81; p < 0.001) and American Indian/Alaska Native (k = 3; OR = 0.78, 95% CI = 0.71, 0.85; p < 0.001) youth, with significant between‐study heterogeneity among Black (Q = 23.99; p < 0.001; I2 = 87%) and Asian (Q = 17.76; p < 0.001; I2 = 83%) youth in effect size comparisons.ConclusionsIn the United States, multiracial youth report distinct alcohol use patterns compared with monoracial youth and may be at elevated alcohol use risk compared with Black and Asian youth.